Threonine Phosphorylation Diverts Internalized Epidermal Growth Factor Receptors from a Degradative Pathway to the Recycling Endosome

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GROWTH FACTOR RECEPTOR TYROSINE KINASES

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The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

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Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1

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c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

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A lipid associated with the antiphospholipid syndrome regulates endosome structure and function

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Phosphoinositides as Regulators in Membrane Traffic

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Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

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Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts

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Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

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Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

1990 • 452 citations

Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation

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EGF Receptor Signaling Stimulates SRC Kinase Phosphorylation of Clathrin, Influencing Clathrin Redistribution and EGF Uptake

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Multiple positive and negative regulators of signaling by the EGF-receptor

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Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms

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The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

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The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor

1991 • 288 citations

Endocytosis of growth factor receptors

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Ubiquitin‐dependent internalization and down‐regulation of plasma membrane proteins

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Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies

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Quantitative analysis of the endocytic system involved in hormone-induced receptor internalization.

1990 • 207 citations

Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.

1985 • 199 citations

Coupling of the c-Cbl protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins.

1996 • 153 citations

The Evolutionarily Conserved N-terminal Region of Cbl Is Sufficient to Enhance Down-regulation of the Epidermal Growth Factor Receptor

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Serine Phosphorylation of Cbl Induced by Phorbol Ester Enhances Its Association with 14-3-3 Proteins in T Cells via a Novel Serine-rich 14-3-3-binding Motif

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Endocytosis and mitogenic signaling

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Detection of ERK activation by a novel monoclonal antibody

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Phosphorylation of the epidermal growth factor receptor at threonine 654 inhibits ligand-induced internalization and down-regulation

1990 • 124 citations

EGF receptor affinity is regulated by intracellular calcium and protein kinase C

1985 • 114 citations

Lysosomal Targeting of Epidermal Growth Factor Receptors via a Kinase-dependent Pathway Is Mediated by the Receptor Carboxyl-terminal Residues 1022-1123

1996 • 108 citations

Epidermal growth factor (EGF) promotes phosphorylation at threonine-654 of the EGF receptor: possible role of protein kinase C in homologous regulation of the EGF receptor.

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A Leucine-based Determinant in the Epidermal Growth Factor Receptor Juxtamembrane Domain Is Required for the Efficient Transport of Ligand-Receptor Complexes to Lysosomes

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1987 • 84 citations

Phorbol ester-induced expression, phosphorylation, and translocation of protein-tyrosine-phosphatase 1C in HL-60 cells.

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High-affinity Binding of Epidermal Growth Factor (EGF) to EGF Receptor Is Disrupted by Overexpression of Mutant Dynamin (K44A)

1998 • 45 citations

Protein Kinase C Activation Inhibits Tyrosine Phosphorylation of Cbl and Its Recruitment of Src Homology 2 Domain-Containing Proteins

1999 • 41 citations

Intensification of Growth Factor Receptor Signalling by Phorbol Treatment of Ligand-primed Cells Implies a Dimer-stabilizing Effect of Protein Kinase C-dependent Juxtamembrane Domain Phosphorylation

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Desensitization of the EGF receptor alters its ability to undergo EGF-induced dimerization

1991 • 13 citations