c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route

Induction of mutant dynamin specifically blocks endocytic coated vesicle formation.

1994 • 1,206 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1

1999 • 1,000 citations

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domain

1994 • 930 citations

Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat.

1991 • 874 citations

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1998 • 865 citations

The structure of an antigenic determinant in a protein

1984 • 841 citations

Mutations in human dynamin block an intermediate stage in coated vesicle formation

1993 • 702 citations

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

1997 • 696 citations

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

2000 • 656 citations

Cbl-b regulates the CD28 dependence of T-cell activation

2000 • 607 citations

Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes.

1996 • 531 citations

Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431.

1979 • 528 citations

Improving structural integrity of cryosections for immunogold labeling

1996 • 502 citations

Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity.

1984 • 467 citations

Ubiquitin Lys63 is involved in ubiquitination of a yeast plasma membrane protein

1997 • 398 citations

Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor.

1989 • 385 citations

Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice

1998 • 371 citations

A Function for Monoubiquitination in the Internalization of a G Protein–Coupled Receptor

1998 • 364 citations

EGF Receptor Signaling Stimulates SRC Kinase Phosphorylation of Clathrin, Influencing Clathrin Redistribution and EGF Uptake

1999 • 347 citations

The EGF receptor: a nexus for trafficking and signaling

2000 • 346 citations

Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7

1999 • 328 citations

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.

1989 • 316 citations

Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbb protein

1985 • 310 citations

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor.

1996 • 307 citations

Regulation of signal transduction by endocytosis

2000 • 299 citations

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

1999 • 299 citations

Similarity of sli-1 , a Regulator of Vulval Development in C. elegans , to the Mammalian Proto-Oncogene c- cbl

1995 • 298 citations

Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes.

1984 • 295 citations

The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

1999 • 291 citations

Monoubiquitin carries a novel internalization signal that is appended to activated receptors

2000 • 291 citations

The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor

1991 • 288 citations

The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor α

1998 • 257 citations

Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system.

1988 • 236 citations

The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.

1991 • 234 citations

Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene.

1994 • 232 citations

Inhibition of the receptor-binding function of clathrin adaptor protein AP-2 by dominant-negative mutant μ2 subunit and its effects on endocytosis

1999 • 212 citations

Quantitative analysis of the endocytic system involved in hormone-induced receptor internalization.

1990 • 207 citations

eps15 and eps15R are essential components of the endocytic pathway.

1997 • 201 citations

Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor

1999 • 194 citations

Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene.

1995 • 185 citations

Requirement for the Adapter Protein GRB2 in EGF Receptor Endocytosis

1996 • 178 citations

Endocytosis: what goes in and how?

1992 • 177 citations

Kinetics of transit of transferrin and epidermal growth factor through clathrin-coated membranes

1984 • 174 citations

Epidermal Growth Factor Receptor Interaction with Clathrin Adaptors Is Mediated by the Tyr974-containing Internalization Motif

1996 • 167 citations

Dynamin Is Required for the Activation of Mitogen-activated Protein (MAP) Kinase by MAP Kinase Kinase

1999 • 165 citations

c-Cbl Is Transiently Tyrosine-phosphorylated, Ubiquitinated, and Membrane-targeted following CSF-1 Stimulation of Macrophages

1996 • 163 citations

Dynamin binds to SH3 domains of phospholipase C gamma and GRB-2.

1994 • 151 citations

High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responses.

1990 • 150 citations

sli-1, a negative regulator of let-23-mediated signaling in C. elegans.

1995 • 149 citations

Recruitment of epidermal growth factor receptors into coated pits requires their activated tyrosine kinase.

1995 • 147 citations

The Evolutionarily Conserved N-terminal Region of Cbl Is Sufficient to Enhance Down-regulation of the Epidermal Growth Factor Receptor

2000 • 143 citations

The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction

1999 • 137 citations

Tyrosine Phosphorylation of Eps15 Is Required for Ligand-Regulated, but Not Constitutive, Endocytosis

2000 • 135 citations

Endocytosis and mitogenic signaling

1999 • 131 citations

The epidermal growth factor receptor is covalently linked to ubiquitin.

1995 • 130 citations

Association and Colocalization of Eps15 with Adaptor Protein-2 and Clathrin

1997 • 124 citations

Interactions of Drosophila Cbl with Epidermal Growth Factor Receptors and Role of Cbl in R7 Photoreceptor Cell Development

1997 • 123 citations

cbl-3: a new mammalian cbl family protein

1999 • 117 citations

Multiple autophosphorylation site mutations of the epidermal growth factor receptor. Analysis of kinase activity and endocytosis

1991 • 114 citations

Human Monocytes and Neutrophils Store Transforming Growth Factor-α in a Subpopulation of Cytoplasmic Granules

1997 • 112 citations

Comparison of rapid changes in surface morphology and coated pit formation of PC12 cells in response to nerve growth factor, epidermal growth factor, and dibutyryl cyclic AMP.

1984 • 112 citations

Polyubiquitination of the Epidermal Growth Factor Receptor Occurs at the Plasma Membrane upon Ligand-induced Activation

2000 • 104 citations

Ubiquitination of the PEST-like Endocytosis Signal of the Yeast a-Factor Receptor

2000 • 103 citations

Kinetics of binding, endocytosis, and recycling of EGF receptor mutants

1992 • 100 citations

Perturbed Regulation of ZAP-70 and Sustained Tyrosine Phosphorylation of LAT and SLP-76 in c-Cbl-Deficient Thymocytes

1999 • 98 citations

Human Monocytes and Neutrophils Store Transforming Growth Factor-α in a Subpopulation of Cytoplasmic Granules

1997 • 91 citations

CSF-1 stimulated multiubiquitination of the CSF-1 receptor and of Cbl follows their tyrosine phosphorylation and association with other signaling proteins

1999 • 90 citations

Overexpression of Cellular Src in Fibroblasts Enhances Endocytic Internalization of Epidermal Growth Factor Receptor

1997 • 90 citations

Internalization and down-regulation of the human epidermal growth factor receptor are regulated by the carboxyl-terminal tyrosines

1991 • 88 citations

A Di-leucine Signal in the Ubiquitin Moiety

2000 • 86 citations

EGF induces recycling membrane to form ruffles

1998 • 82 citations

Endocytosis and intracellular sorting of receptor tyrosine kinases

1998 • 69 citations

The Cbl Family of Signal Transduction Molecules

1997 • 67 citations

c‐Cbl: A regulator of T cell receptor‐mediated signalling

1998 • 63 citations

Molecular cloning and characterization of a novel cbl-family gene, cbl-c

1999 • 58 citations

A Drosophila analogue of v-Cbl is a dominant-negative oncoprotein in vivo

2000 • 29 citations

Sequential appearance of epidermal growth factor in plasma membrane-associated and intracellular vesicles during endocytosis.

1987 • 15 citations