Early Endosomal Regulation of Smad-dependent Signaling in Endothelial Cells

A simplified system for generating recombinant adenoviruses

1998 • 3,179 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway

1992 • 1,342 citations

Induction of mutant dynamin specifically blocks endocytic coated vesicle formation.

1994 • 1,206 citations

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

1998 • 1,101 citations

rab5 controls early endosome fusion in vitro

1991 • 1,090 citations

Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells

2000 • 1,087 citations

Rab7: A Key to Lysosome Biogenesis

2000 • 1,038 citations

Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis

1996 • 998 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis.

1994 • 948 citations

Receptor-associated Mad homologues synergize as effectors of the TGF-β response

1996 • 874 citations

Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

2000 • 823 citations

Dynamin-mediated Internalization of Caveolae

1998 • 750 citations

EEA1, an Early Endosome-Associated Protein.

1995 • 706 citations

Mutations in human dynamin block an intermediate stage in coated vesicle formation

1993 • 702 citations

Dynamin at the Neck of Caveolae Mediates Their Budding to Form Transport Vesicles by GTP-driven Fission from the Plasma Membrane of Endothelium

1998 • 657 citations

Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase

1998 • 542 citations

Vascular development: cellular and molecular regulation

1997 • 532 citations

Rab5 regulates motility of early endosomes on microtubules

1999 • 504 citations

A role for Smad6 in development and homeostasis of the cardiovascular system

2000 • 488 citations

A murine model of hereditary hemorrhagic telangiectasia

1999 • 472 citations

Endoglin, an Ancillary TGFβ Receptor, Is Required for Extraembryonic Angiogenesis and Plays a Key Role in Heart Development

2000 • 433 citations

Regulation of Smad Activity

2000 • 419 citations

Rabenosyn-5, a Novel Rab5 Effector, Is Complexed with Hvps45 and Recruited to Endosomes through a Fyve Finger Domain

2000 • 373 citations

FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes

2001 • 302 citations

Regulation of signal transduction by endocytosis

2000 • 299 citations

The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5

2000 • 288 citations

Microtubule Binding to Smads May Regulate TGFβ Activity

2000 • 277 citations

Epidermal Growth Factor and Membrane Trafficking

2000 • 233 citations

Non‐replicating vaccinia vector efficiently expresses bacteriophage T7 RNA polymerase

1995 • 229 citations

The small GTP binding protein rab7 is essential for cellular vacuolation induced by Helicobacter pylori cytotoxin

1997 • 216 citations

FYVE-finger proteins – effectors of an inositol lipid

1999 • 199 citations

Hgs (Hrs), a FYVE Domain Protein, Is Involved in Smad Signaling through Cooperation with SARA

2000 • 176 citations

Interaction of the EEA1 FYVE Finger with Phosphatidylinositol 3-Phosphate and Early Endosomes

2000 • 145 citations

Physical and Functional Interactions between Type I Transforming Growth Factor β Receptors and Bα, a WD-40 Repeat Subunit of Phosphatase 2A

1998 • 127 citations

The N-myc oncogene in human neuroblastoma cells: down-regulation of an angiogenesis inhibitor identified as activin A.

2000 • 115 citations

Ligand-independent Activation of Transforming Growth Factor (TGF) β Signaling Pathways by Heteromeric Cytoplasmic Domains of TGF-β Receptors

1996 • 108 citations

Rare diseases bullet 5: Primary pulmonary hypertension

1999 • 92 citations

High-Affinity Binding of a FYVE Domain to Phosphatidylinositol 3-Phosphate Requires Intact Phospholipid but Not FYVE Domain Oligomerization

2001 • 86 citations

Growth factor receptor signalling: location, location, location

2000 • 67 citations

Long-Term Consequences of Interleukin-6 Overexpression in Transgenic Mice

1992 • 60 citations

Transforming Growth Factor (TGF)-β1 Internalization

2001 • 49 citations

E-selectin Gene Expression Is Induced Synergistically with the Coexistence of Activated Classic Protein Kinase C and Signals Elicited by Interleukin-1β but Not Tumor Necrosis Factor-α

1999 • 18 citations