GFRα-Mediated Localization of RET to Lipid Rafts Is Required for Effective Downstream Signaling, Differentiation, and Neuronal Survival

Functional rafts in cell membranes

1997 • 9,471 citations

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

1998 • 2,942 citations

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

1992 • 2,905 citations

THE CAVEOLAE MEMBRANE SYSTEM

1998 • 1,947 citations

GDNF: a Potent Survival Factor for Motoneurons Present in Peripheral Nerve and Muscle

1994 • 1,261 citations

GPI-anchored proteins are organized in submicron domains at the cell surface

1998 • 1,207 citations

GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF

1996 • 1,170 citations

Characterization of a multicomponent receptor for GDNF

1996 • 1,086 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP.

1993 • 886 citations

GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases

1991 • 848 citations

Functional Interactions of Neurotrophins and Neurotrophin Receptors

1995 • 825 citations

GDNF signalling through the Ret receptor tyrosine kinase

1996 • 809 citations

Functional receptor for GDNF encoded by the c-ret proto-oncogene

1996 • 795 citations

A detergent-free method for purifying caveolae membrane from tissue culture cells.

1995 • 732 citations

Neurturin, a relative of glial-cell-line-derived neurotrophic factor

1996 • 711 citations

Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF

1995 • 686 citations

Induction of nerve growth factor receptor in Schwann cells after axotomy.

1986 • 614 citations

Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons.

1995 • 595 citations

Artemin, a Novel Member of the GDNF Ligand Family, Supports Peripheral and Central Neurons and Signals through the GFRα3–RET Receptor Complex

1998 • 578 citations

GFRα1 Is an Essential Receptor Component for GDNF in the Developing Nervous System and Kidney

1998 • 550 citations

Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin

1998 • 499 citations

Complementary and Overlapping Expression of Glial Cell Line-Derived Neurotrophic Factor (GDNF), c-ret Proto-Oncogene, and GDNF Receptor-α Indicates Multiple Mechanisms of Trophic Actions in the Adult Rat CNS

1997 • 494 citations

Cellular Cholesterol Efflux Mediated by Cyclodextrins

1996 • 456 citations

Looking at lipid rafts?

1999 • 406 citations

GDNF is an age-specific survival factor for sensory and autonomic neurons

1995 • 401 citations

A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor

1997 • 397 citations

TrnR2, a Novel Receptor That Mediates Neurturin and GDNF Signaling through Ret

1997 • 357 citations

Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytes.

1995 • 355 citations

EphrinB Ligands Recruit GRIP Family PDZ Adaptor Proteins into Raft Membrane Microdomains

1999 • 345 citations

Neurturin Exerts Potent Actions on Survival and Function of Midbrain Dopaminergic Neurons

1998 • 339 citations

Ret-dependent and -independent Mechanisms of Glial Cell Line-derived Neurotrophic Factor Signaling in Neuronal Cells

1999 • 322 citations

Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins

1997 • 302 citations

Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase

1997 • 300 citations

The nature of large noncovalent complexes containing glycosyl-phosphatidylinositol-anchored membrane glycoproteins and protein tyrosine kinases.

1992 • 300 citations

Engagement of GPI-Linked CD48 Contributes to TCR Signals and Cytoskeletal Reorganization

1998 • 278 citations

Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system

1999 • 265 citations

Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains.

1996 • 246 citations

Differential Regulation of mRNAs for GDNF and its Receptors Ret and GDNFRα After Sciatic Nerve Lesion in the Mouse

1997 • 242 citations

GFRα-2 and GFRα-3 Are Two New Receptors for Ligands of the GDNF Family

1997 • 229 citations

Neurturin and GDNF Promote Proliferation and Survival of Enteric Neuron and Glial Progenitorsin Vitro

1998 • 228 citations

Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons

1997 • 226 citations

Metabolic and Genetic Analyses of Apoptosis in Potassium/Serum-Deprived Rat Cerebellar Granule Cells

1996 • 216 citations

Expression of GDNF Family Receptor Components during Development: Implications in the Mechanisms of Interaction

1998 • 190 citations

Expression of neurturin, GDNF, and their receptors in the adult mouse CNS

1998 • 171 citations

Glial Cell Line-derived Neurotrophic Factor Signals through the RET Receptor and Activates Mitogen-activated Protein Kinase

1996 • 168 citations

GFRα-4 and the tyrosine kinase Ret form a functional receptor complex for persephin

1998 • 156 citations

cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily.

1993 • 155 citations

Glial cell line‐derived neurotrophic factor stimulates fiber formation and survival in cultured neurons from peripheral autonomic ganglia

1995 • 133 citations

GFRα3 is an orphan member of the GDNF/neurturin/persephin receptor family

1998 • 132 citations

Generation of Neuronal Intranuclear Inclusions by Polyglutamine-GFP: Analysis of Inclusion Clearance and Toxicity as a Function of Polyglutamine Length

1999 • 95 citations

Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha

1997 • 94 citations

Glycosyl-phosphatidylinositol anchored membrane enzymes

1997 • 93 citations

Activation of Src Family Members Is Not Required for the Platelet-Derived Growth Factor β Receptor To Initiate Mitogenesis

1998 • 57 citations

Role for a Glycan Phosphoinositol Anchor in Fcγ Receptor Synergy

1997 • 52 citations

Ret-mediated mitogenesis requires Src kinase activity.

1999 • 49 citations

Expression of a liver fatty acid binding protein/human decay-accelerating factor/HLA-B44 chimeric gene in transgenic mice

1991 • 10 citations