Export of Antigenic Peptides from the Endoplasmic Reticulum Intersects with Retrograde Protein Translocation through the Sec61p Channel

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1996 • 1,101 citations

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

1996 • 1,083 citations

MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING

1998 • 1,017 citations

IMMUNODOMINANCE IN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I–RESTRICTED T LYMPHOCYTE RESPONSES

1999 • 923 citations

DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

1999 • 898 citations

Peptides Naturally Presented by MHC Class I Molecules

1993 • 803 citations

[6] Preparation of microsomal membranes for cotranslational protein translocation

1983 • 679 citations

PROTEIN TRANSPORT ACROSS THE EUKARYOTIC ENDOPLASMIC RETICULUM AND BACTERIAL INNER MEMBRANES

1996 • 560 citations

Selective and ATP-Dependent Translocation of Peptides by the MHC-Encoded Transporter

1993 • 556 citations

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

1997 • 556 citations

Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products.

1986 • 547 citations

ER Quality Control: The Cytoplasmic Connection

1997 • 528 citations

Involvement of GTP-binding “G” proteins in transport through the Golgi stack

1987 • 495 citations

Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation

1997 • 412 citations

Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP.

1996 • 400 citations

Retrograde protein translocation: ERADication of secretory proteins in health and disease

1999 • 371 citations

TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective

1993 • 365 citations

Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47.

1996 • 350 citations

Accumulating Evidence Suggests That Several AB-Toxins Subvert the Endoplasmic Reticulum-Associated Protein Degradation Pathway To Enter Target Cells

1997 • 316 citations

Characterization of a monoclonal anti‐β₂‐microglobulin antibody and its use in the genetic and biochemical analysis of major histocompatibility antigens

1979 • 308 citations

Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome

1997 • 295 citations

Tumor rejection antigen gp96/grp94 is an ATPase: implications for protein folding and antigen presentation.

1993 • 293 citations

A set of endoplasmic reticulum proteins possessing properties of molecular chaperones includes Ca(2+)-binding proteins and members of the thioredoxin superfamily.

1994 • 279 citations

Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP.

1996 • 271 citations

Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol

1990 • 233 citations

Peptide size selection by the major histocompatibility complex-encoded peptide transporter.

1994 • 212 citations

Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator.

1994 • 207 citations

Cholera Toxin Is Exported from Microsomes by the Sec61p Complex

2000 • 201 citations

Export of a Cysteine-Free Misfolded Secretory Protein from the Endoplasmic Reticulum for Degradation Requires Interaction with Protein Disulfide Isomerase

1999 • 194 citations

Peptide Translocation by Variants of the Transporter Associated with Antigen Processing

1993 • 188 citations

Toxin Entry: Retrograde Transport through the Secretory Pathway

1998 • 186 citations

Interaction of heavy chain binding protein (BiP/GRP78) with adenine nucleotides.

1989 • 176 citations

TAP‐translocated peptides specifically bind proteins in the endoplasmic reticulum, including gp96, protein disulfide isomerase and calreticulin

1997 • 171 citations

Trimming of antigenic peptides in an early secretory compartment.

1994 • 169 citations

Expression of a membrane protease enhances presentation of endogenous antigens to MHC class I-restricted T lymphocytes

1992 • 155 citations

Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling.

1994 • 151 citations

The Pathway of Us11-Dependent Degradation of Mhc Class I Heavy Chains Involves a Ubiquitin-Conjugated Intermediate

1999 • 150 citations

Ricin A chain utilises the endoplasmic reticulum‐associated protein degradation pathway to enter the cytosol of yeast

1999 • 150 citations

Translocation of long peptides by transporters associated with antigen processing (TAP)

1996 • 149 citations

In Vitro Dissociation of BiP-Peptide Complexes Requires a Conformational Change in BiP after ATP Binding but Does Not Require ATP Hydrolysis

1995 • 143 citations

The KDEL retrieval system is exploited by Pseudomonas exotoxin A, but not by Shiga-like toxin-1, during retrograde transport from the Golgi complex to the endoplasmic reticulum

1999 • 137 citations

Novel allele-specific, post-translational reduction in HLA class I surface expression in a mutant human B cell line.

1994 • 136 citations

ATP induces a conformational change of the 90-kDa heat shock protein (hsp90).

1993 • 133 citations

Translocation of ATP into the lumen of rough endoplasmic reticulum-derived vesicles and its binding to luminal proteins including BiP (GRP 78) and GRP 94.

1992 • 131 citations

ATP hydrolysis cycles and mechanism inP-glycoprotein and CFTR

1997 • 130 citations

Conformational Changes Induced in the Endoplasmic Reticulum Luminal Domain of Calnexin by Mg-ATP and Ca2+

1995 • 130 citations

A microsomal ATP-binding protein involved in efficient protein transport into the mammalian endoplasmic reticulum.

1996 • 128 citations

IDENTIFICATION OF NOVEL

1964 • 128 citations

The Engagement of Sec61p in the ER Dislocation Process

1999 • 127 citations

The endoplasmic reticulum‐resident stress protein gp96 binds peptides translocated by TAP

1997 • 117 citations

Generation and TAP-Mediated Transport of Peptides for Major Histocompatibility Complex Class I Molecules

1998 • 102 citations

Assembly, Intracellular Localization, and Nucleotide Binding Properties of the Human Peptide Transporters TAP1 and TAP2 Expressed by Recombinant Vaccinia Viruses

1995 • 88 citations

Up-regulation of MHC class I by flavivirus-induced peptide translocation into the endoplasmic reticulum

1995 • 76 citations

Identification of a contact region for peptide on the TAP1 chain of the transporter associated with antigen processing.

1996 • 75 citations

Identification of Novel Peptide Binding Proteins in the Endoplasmic Reticulum: ERp72, Calnexin, and grp170

1999 • 70 citations

Uneven tissue distribution of minor histocompatibility proteins versus peptides is caused by MHC expression

1991 • 68 citations

An ATP transporter is required for protein translocation into the yeast endoplasmic reticulum.

1993 • 65 citations

Herpes Simplex Virus Inhibitor ICP47 Destabilizes the Transporter Associated with Antigen Processing (TAP) Heterodimer

1998 • 65 citations

Protein disulfide isomerase is the dominant acceptor for peptides translocated into the endoplasmic reticulum

1997 • 54 citations

A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins.

1995 • 49 citations

Similar processes mediate glycopeptide export from the endoplasmic reticulum in mammalian cells and Saccharomyces cerevisiae

1997 • 42 citations

The role of MHC class I molecules in the generation of endogenous peptide/MHC complexes.

1995 • 41 citations

Transport of adenosine triphosphate into endoplasmic reticulum proteoliposomes

1995 • 41 citations

Novel Peptide-Binding Proteins and Peptide Transport in Normal and TAP-Deficient Microsomes

1997 • 39 citations

ATP Binding and Hydrolysis by the Multifunctional Protein Disulfide Isomerase

1996 • 37 citations

Labeling of Adenine and Guanine Nucleotide-Binding Proteins in Permeabilized Cells with in Situ Periodate-Oxidized Nucleotides

1993 • 17 citations