An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

2002 • 620 citations

Antigen processing by the proteasome

2001 • 620 citations

An IFN-γ–induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I–presented peptides

2002 • 518 citations

A Giant Protease with Potential to Substitute for Some Functions of the Proteasome

1999 • 377 citations

Homozygous Human TAP Peptide Transporter Mutation in HLA Class I Deficiency

1994 • 348 citations

Interferon-γ Can Stimulate Post-proteasomal Trimming of the N Terminus of an Antigenic Peptide by Inducing Leucine Aminopeptidase

1998 • 297 citations

Two new proteases in the MHC class I processing pathway

2000 • 253 citations

The Interferon-γ-inducible 11 S Regulator (PA28) and the LMP2/LMP7 Subunits Govern the Peptide Production by the 20 S Proteasome in Vitro

1995 • 233 citations

Proteolysis and class I major histocompatibility complex antigen presentation

1999 • 232 citations

ER aminopeptidases generate a unique pool of peptides for MHC class I molecules

2001 • 184 citations

Characterization and inhibition of a cholecystokinin-inactivating serine peptidase

1996 • 168 citations

Efficient Generation of a Hepatitis B Virus Cytotoxic T Lymphocyte Epitope Requires the Structural Features of Immunoproteasomes

2000 • 161 citations

Tripeptidyl peptidases: enzymes that count

1999 • 145 citations

Distinct Proteolytic Processes Generate the C and N Termini of MHC Class I-Binding Peptides

1999 • 144 citations

Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity

2000 • 118 citations

Cut and trim: generating MHC class I peptide ligands

2001 • 111 citations

Proteasomes and Antigen Processing

1997 • 106 citations

Purification, substrate specificity, and classification of tripeptidyl peptidase II.

1986 • 103 citations

The Final N-Terminal Trimming of a Subaminoterminal Proline-Containing HLA Class I-Restricted Antigenic Peptide in the Cytosol Is Mediated by Two Peptidases

2002 • 91 citations

Peptide motifs of HLA-A1,-A11,-A31, and-A33 molecules

1994 • 88 citations

Major Histocompatibility Complex Class I Viral Antigen Processing in the Secretory Pathway Defined by the trans-Golgi Network Protease Furin

1998 • 82 citations

Cytotoxic T Lymphocyte Epitopes of HIV-1 Nef

2000 • 80 citations

The specificity of proteasomes: impact on MHC class I processing and presentation of antigens

1999 • 76 citations

Allelic Differences in the Relationship Between Proteasome Activity and MHC Class I Peptide Loading

1998 • 75 citations

Efficient MHC Class I-Independent Amino-Terminal Trimming of Epitope Precursor Peptides in the Endoplasmic Reticulum

2001 • 74 citations

26 S Proteasome-mediated Production of an Authentic Major Histocompatibility Class I-restricted Epitope from an Intact Protein Substrate

1999 • 63 citations

The RTP Site Shared by the HIV-1 Tat Protein and the 11S Regulator Subunit α is Crucial for their Effects on Proteasome Function Including Antigen Processing

2002 • 58 citations

IFN-gamma exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase.

1999 • 58 citations

Characteristics of HIV-1 Nef Regions Containing Multiple CD8+ T Cell Epitopes: Wealth of HLA-Binding Motifs and Sensitivity to Proteasome Degradation

2001 • 51 citations

IFN-γ Exposes a Cryptic Cytotoxic T Lymphocyte Epitope in HIV-1 Reverse Transcriptase

1999 • 51 citations

Active site of tripeptidyl peptidase II from human erythrocytes is of the subtilisin type.

1987 • 49 citations

Tripeptidyl Peptidase II Promotes Maturation of Caspase-1 inShigella flexneri-Induced Macrophage Apoptosis

2000 • 45 citations

A Role for a Novel Luminal Endoplasmic Reticulum Aminopeptidase in Final Trimming of 26 S Proteasome-generated Major Histocompatability Complex Class I Antigenic Peptides

2001 • 45 citations

The Murine Cytomegalovirus pp89 Immunodominant H-2Ld Epitope Is Generated and Translocated into the Endoplasmic Reticulum as an 11-Mer Precursor Peptide

2001 • 43 citations

Two Human Immunodeficiency Virus Vaccinal Lipopeptides Follow Different Cross-Presentation Pathways in Human Dendritic Cells

2002 • 42 citations

The human multicatalytic proteinase: affinity purification using a monoclonal antibody

1991 • 42 citations