Orchestrating nuclear functions: ubiquitin sets the rhythm

Translating the Histone Code

2001 • 9,488 citations

Genome maintenance mechanisms for preventing cancer

2001 • 3,819 citations

Mechanisms Underlying Ubiquitination

2001 • 3,555 citations

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

2002 • 2,139 citations

Active genes are tri-methylated at K4 of histone H3

2002 • 2,064 citations

Themes and variations on ubiquitylation

2001 • 1,475 citations

Histone modifications in transcriptional regulation

2002 • 1,200 citations

Protein regulation by monoubiquitin

2001 • 1,195 citations

Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast

2002 • 1,050 citations

Sumo, ubiquitin's mysterious cousin

2001 • 749 citations

Rad6-Dependent Ubiquitination of Histone H2B in Yeast

2000 • 662 citations

Siah-1, SIP, and Ebi Collaborate in a Novel Pathway for β-Catenin Degradation Linked to p53 Responses

2001 • 586 citations

Transcriptional Coactivator Complexes

2001 • 569 citations

The 26S Proteasome Is Required for Estrogen Receptor-α and Coactivator Turnover and for Efficient Estrogen Receptor-α Transactivation

2000 • 561 citations

Mammalian G1- and S-phase checkpoints in response to DNA damage

2001 • 560 citations

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2

2001 • 554 citations

MDM2–HDAC1-mediated deacetylation of p53 is required for its degradation

2002 • 554 citations

Methylation of Histone H3 by COMPASS Requires Ubiquitination of Histone H2B by Rad6

2002 • 548 citations

The LIM domain: regulation by association

2000 • 547 citations

Bre1, an E3 Ubiquitin Ligase Required for Recruitment and Substrate Selection of Rad6 at a Promoter

2003 • 515 citations

Trans-histone regulatory pathway in chromatin

2002 • 502 citations

The anaphase-promoting complex: it's not just for mitosis any more

2002 • 494 citations

A Conserved RING Finger Protein Required for Histone H2B Monoubiquitination and Cell Size Control

2003 • 434 citations

Siah-1 Mediates a Novel β-Catenin Degradation Pathway Linking p53 to the Adenomatous Polyposis Coli Protein

2001 • 416 citations

Regulation of Transcriptional Activation Domain Function by Ubiquitin

2001 • 363 citations

Recruitment of a 19 S Proteasome Subcomplex to an Activated Promoter

2002 • 340 citations

Drosophila Neuralized Is a Ubiquitin Ligase that Promotes the Internalization and Degradation of Delta

2001 • 333 citations

Ubiquitin and its kin: how close are the family ties?

2000 • 316 citations

Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase

2001 • 308 citations

Human Origin Recognition Complex Large Subunit Is Degraded by Ubiquitin-Mediated Proteolysis after Initiation of DNA Replication

2002 • 302 citations

Regulation of Transcription by Ubiquitination without Proteolysis

2000 • 292 citations

B-cell-specif ic coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation

1996 • 284 citations

Stabilization of the MDM2 Oncoprotein by Interaction with the Structurally Related MDMX Protein

1999 • 282 citations

The 19S Regulatory Particle of the Proteasome Is Required for Efficient Transcription Elongation by RNA Polymerase II

2001 • 266 citations

Regulating the Regulators

2003 • 261 citations

neuralized Encodes a Peripheral Membrane Protein Involved in Delta Signaling and Endocytosis

2001 • 258 citations

Ubiquitin-Activating/Conjugating Activity of TAF _II 250, a Mediator of Activation of Gene Expression in Drosophila

2000 • 238 citations

A Rad26–Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage

2002 • 230 citations

Xenopus Neuralized Is a Ubiquitin Ligase that Interacts with XDelta1 and Regulates Notch Signaling

2001 • 225 citations

Ultraviolet Radiation-induced Ubiquitination and Proteasomal Degradation of the Large Subunit of RNA Polymerase II

1998 • 221 citations

The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase

1997 • 206 citations

Mammalian homologs of seven in absentia regulate DCC via the ubiquitin–proteasome pathway

1997 • 189 citations

The Contribution of Nuclear Compartmentalization to Gene Regulation

2002 • 185 citations

Rsp5 Ubiquitin-Protein Ligase Mediates DNA Damage-Induced Degradation of the Large Subunit of RNA Polymerase II in Saccharomyces cerevisiae

1999 • 169 citations

Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors

2002 • 168 citations

Regulation of Synaptophysin Degradation by Mammalian Homologues of Seven in Absentia

2002 • 164 citations

RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex

1999 • 143 citations

Assembly of the SMRT–histone deacetylase 3 repression complex requires the TCP-1 ring complex

2002 • 135 citations

Dual Regulation of the Met4 Transcription Factor by Ubiquitin-Dependent Degradation and Inhibition of Promoter Recruitment

2002 • 122 citations

Rapid Induction of Histone Hyperacetylation and Cellular Differentiation in Human Breast Tumor Cell Lines following Degradation of Histone Deacetylase-1

2000 • 105 citations

Siah-1 binds and regulates the function of Numb

2001 • 96 citations

SIAH-1 interacts with α-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis

2000 • 84 citations

p53 Suppresses the c-Myb-induced Activation of Heat Shock Transcription Factor 3

2000 • 83 citations

Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation

2002 • 80 citations

Modulation of Transforming Growth Factor β (TGFβ)/Smad Transcriptional Responses through Targeted Degradation of TGFβ-inducible Early Gene-1 by Human Seven in Absentia Homologue

2002 • 76 citations

Regulation of BOB.1/OBF.1 stability by SIAH

2001 • 73 citations

The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1

2001 • 72 citations

Regulated Proteolysis of Xom Mediates Dorsoventral Pattern Formation during Early Xenopus Development

2002 • 38 citations

A Role for Histone H2B During Repair of UV-Induced DNA Damage in Saccharomyces cerevisiae

2002 • 29 citations