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Human microglia convert <scp>l</scp>-tryptophan into the neurotoxin quinolinic acid

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1988 • 126 citations

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Modulation of seizure susceptibility in the mouse by the strychnine‐insensitive glycine recognition site of the NMDA receptor/ion channel complex

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The excitotoxin quinolinic acid is present in the brain of several mammals and its cortical content increases during the aging process

1984 • 108 citations

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1991 • 103 citations

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1996 • 100 citations

4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-γ-stimulated monocytes (THP-1 cells)

1993 • 97 citations

(R,S)-3,4-dichlorobenzoylalanine (FCE 28833A) causes a large and persistent increase in brain kynurenic acid levels in rats

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The preferred route of kynurenine metabolism in the rat

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Neurotoxin Quinolinic Acid Is Selectively Elevated in Spinal Cords of Rats with Experimental Allergic Encephalomyelitis

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Delayed Increases in Regional Brain Quinolinic Acid Follow Transient Ischemia in the Gerbil

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Molecular cloning of rat kynurenine aminotransferase: Identity with glutamine transaminase K

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Organ Distribution of Rat Kynureninase and Changes of Its Activity during Development

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The glycine antagonist and free radical scavenger 7-C1-thio-kynurenate reduces CA1 ischemic damage in the gerbil

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A radiometric assay for kynurenine 3-hydroxylase based on the release of 3H2O during hydroxylation of l-[3,5-3H]kynurenine

1992 • 42 citations

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Increased Concentrations of 3‐Hydroxykynurenine in Vitamin B₆ Deficient Neonatal Rat Brain

1987 • 39 citations

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Cloning and Characterization of a Soluble Kynurenine Aminotransferase from Rat Brain: Identity with Kidney Cysteine Conjugate β‐Lyase

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Pretreatment with l-kynurenine, the precursor to the excitatory amino acid antagonist kynurenic acid, suppresses epileptiform activity in combined entorhinal/hippocampal slices

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Deduced primary structure of rat tryptophan-2,3-dioxygenase

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Tryptophan reversal of recombinant human gamma-interferon inhibition ofChlamydia trachomatis growth

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Quinolinic Acid and the Kynurenines

1988 • 33 citations

Tryptophan and its metabolite, kynurenine, stimulate expression of nerve growth factor in cultured mouse astroglial cells

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3-Hydroxyanthranilic acid oxygenase-containing astrocytic processes surround glutamate-containing axon terminals in the rat striatum

1995 • 31 citations

High Activities of Glutamine Transaminase K (Dichlorovinylcysteine β‐Lyase) and ω‐Amidase in the Choroid Plexus of Rat Brain

1993 • 31 citations

6-Chloro-d,l-tryptophan, 4-chloro-3-hydroxyanthranilate and dexamethasone attenuate quinolinic acid accumulation in brain and blood following systemic immune activation

1994 • 30 citations

Localization of quinolinic acid in the murine AIDS model of retrovirus-induced immunodeficiency: implications for neurotoxicity and dendritic cell immunopathogenesis

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L-Kynurenine 3-Monooxygenase from Mitochondrial Outer Membrane of Pig Liver: Purification, Some Properties, and Monoclonal Antibodies Directed to the Enzyme

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1991 • 24 citations

Cloning and recombinant expression of rat and human kynureninase

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Regrowth of cholinergic and catecholaminergic neurons along a peripheral and central nervous pathway

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Regulation of the Kynurenine Pathway by IFN-γ in Murine Cloned Macrophages and Microglial Cells

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Depressor effect of kynurenine and its metabolites in rats

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Neuropsychiatry Implications of Brain Tryptophan Perturbations Appearing in Hepatic Encephalopathy

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Identification and Measurement of Oxindole (2-Indolinone) in the Mammalian Brain and Other Rat Organs

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Effects of 540C91 [(E)-3-[2-(4′pyridyl)-vinyl]-1H-indole], an inhibitor of hepatic tryptophan dioxygenase, on brain quinolinic acid in mice

1996 • 16 citations

Full length article

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Kynureninase and Kynurenine 3-Hydroxylase in Mammalian Tissues

1991 • 15 citations

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Effects of Mitochondria and O‐Methoxybenzoylalanine on 3‐Hydroxyanthranilic Acid Dioxygenase Activity and Quinolinic Acid Synthesis

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Isolation and characterization of an hydroxykynureninase from homogenates of adult mouse liver

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Discovery of a novel and alternate hydrogen peroxide generation machinery in the mammalian thyroid gland that modulates iodination of tyrosine

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Indoleamine Dioxygenase - a Possible Biological Function

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Kynurenine Hydroxylase and Kynureninase Inhibitors as Tools to Study the Role of Kynurenine Metabolites in the Central Nervous System

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Molecular Characterisation of Kynurenine Pathway Enzymes

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Effects of central administration of kynurenic acid on spontaneous locomotor activity in the kindled rat: A multivariate approach using the automated digiscan monitoring system

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SOME NEW COMPOUNDS EXHIBITING SELECTIVE CNS-DEPRESSANT ACTIVITIES. I. PRELIMINARY OBSERVATIONS.

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NMDA receptor heterogeneity in mammalian tissues: focus on two agonists, (2S,3R,4S) cyclopropylglutamate and the sulfate ester of 4-hydroxy-(S)-pipecolic acid

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Kynurenine and probenecid prevent quinolinic acid-induced neurotoxicity in rat corpus striatum.

1994 • 3 citations

ChemInform Abstract: Synthesis and Activity of Enantiopure (S) (m-Nitrobenzoyl)alanine, a Potent Kynurenine-3-hydroxylase Inhibitor.

1995 • 2 citations

Deleted Work

1955 • 0 citations