The effects of a novel and selective inhibitor of tryptophan 2,3-dioxygenase on tryptophan and serotonin metabolism in the rat

Structure and function of the brain serotonin system

1992 • 2,507 citations

5-HIAA in the Cerebrospinal Fluid

1976 • 1,430 citations

Partial Purification and Characterization of Tryptophan Hydroxylase from Rabbit Hindbrain

1972 • 445 citations

EFFECT OF ALBUMIN BINDING AND AMINO ACID COMPETITION ON TRYPTOPHAN UPTAKE INTO BRAIN

1977 • 200 citations

Rapid serotonin depletion as a provocative challenge test for patients with major depression: relevance to antidepressant action and the neurobiology of depression.

1991 • 191 citations

Serotonin selectively attenuates glutamate-evoked activation of noradrenergic locus coeruleus neurons

1991 • 181 citations

[26] Indoleamine 2,3-dioxygenase

1987 • 176 citations

Biogenic amine hypothesis of affective disorders

1979 • 148 citations

EFFECTS ON PLASMA AND BRAIN TRYPTOPHAN IN THE RAT OF DRUGS AND HORMONES THAT INFLUENCE THE CONCENTRATION OF UNESTERIFIED FATTY ACID IN THE PLASMA

1974 • 141 citations

Quantification of the importance of individual steps in the control of aromatic amino acid metabolism

1986 • 141 citations

The role of tryptophan 2,3-dioxygenase in the hormonal control of tryptophan metabolism in isolated rat liver cells. Effects of glucocorticoids and experimental diabetes

1985 • 134 citations

5-hydroxyindoleacetic acid in cerebrospinal fluid and prediction of suicidal behaviour in schizophrenia

1992 • 108 citations

Colorimetric assay for monoamine oxidase in tissues using peroxidase and 2,2′-azinodi(3-ethylbenzthiazoline-6-sulfonic acid) as chromogen

1984 • 107 citations

The clinical psychopharmacology of tryptophan

1986 • 91 citations

The brain serotonergic system in the affective disorders

1978 • 86 citations

Increase of brain tryptophan and stimulation of serotonin synthesis by salicylate

1973 • 80 citations

Effect of Precursor Loading on the Synthesis Rate and Release of Dopamine and Serotonin in the Striatum: A Microdialysis Study in Conscious Rats

1991 • 78 citations

Transport of the aromatic amino acids into isolated rat liver cells. Properties of uptake by two distinct systems

1986 • 70 citations

The use of tryptophan depletion to evaluate central serotonin function in depression and other neuropsychiatric disorders

1993 • 68 citations

How does displacement of albumin-bound tryptophan cause sustained increases in the free tryptophan concentration in plasma and 5-hydroxytryptamine synthesis in brain?

1989 • 63 citations

Tryptophan Availability Modulates Serotonin Release from Rat Hypothalamic Slices

1989 • 61 citations

Electrophysiological assessment of the effects of antidepressant treatments on the efficacy of 5-HT neurotransmission.

1988 • 59 citations

Effect of chronic administration of antidepressant drugs on 5-HT2-mediated behavior in the rat following noradrenergic or serotonergic denervation

1991 • 55 citations

Indoleamine 2,3-dioxygenase. A new, rapid, sensitive radiometric assay and its application to the study of the enzyme in rat tissues

1980 • 54 citations

Calcium‐Dependent, Tetrodotoxin‐Sensitive Stimulation of Cortical Serotonin Release After a Tryptophan Load

1989 • 54 citations

Serotonergic mechanisms of depression.

1988 • 52 citations

Pharmacokinetics of tryptophan, renal handling of kynurenine and the effect of nicotinamide on its appearance in plasma and urine following L-tryptophan loading of healthy subjects

1981 • 46 citations

Use of tryptophan in combination with other antidepressant treatments: a review.

1991 • 35 citations

Tryptophan-deficient diet and amino acid drink deplete plasma tryptophan and induce a relapse of depression in susceptible patients

1992 • 34 citations

Effect of 8-hydroxy-2-(di-n-propylamino)-tetralin on the tryptophan-induced increase in 5-hydroxytryptophan accumulation in rat brain

1990 • 31 citations

New Antidepressants

1993 • 28 citations

Tryptophan tolerance and metabolism in endogenous depression

1982 • 27 citations

The control of aromatic amino acid catabolism and its relationship to neurotransmitter amine synthesis.

1989 • 26 citations

The influence of starvation and tryptophan administration on the metabolism of phenylalanine, tyrosine and tryptophan in isolated rat liver cells

1984 • 23 citations

Prolactin-lowering ability of (+/-)-idazoxan may be linked to a central noradrenergic-serotonergic interplay.

1989 • 16 citations

Chronic dexmedetomidine, a selective α2-agonist, decreases serotonin but not noradrenaline turnover in rat brainstem nuclei

1990 • 12 citations

Review of Pharmacology of Depression.

1967 • 12 citations

The role of haem in the regulation of rat liver tryptophan metabolism

1986 • 7 citations

Tryptophan degradation and indoleamine 2,3-dioxygenase in MRC-5 fibroblasts

1989 • 5 citations