6-Chloro-d,l-tryptophan, 4-chloro-3-hydroxyanthranilate and dexamethasone attenuate quinolinic acid accumulation in brain and blood following systemic immune activation

Quinolinic Acid: An Endogenous Metabolite That Produces Axon-Sparing Lesions in Rat Brain

1983 • 1,247 citations

Blood–Brain Barrier Transport of Kynurenines: Implications for Brain Synthesis and Metabolism

1991 • 705 citations

QUINOLINIC ACID AND KYNURENINE PATHWAY METABOLISM IN INFLAMMATORY AND NON-INFLAMMATORY NEUROLOGICAL DISEASE

1992 • 655 citations

Quinolinic acid in cerebrospinal fluid and serum in HIV‐1 Infection: Relationship to clinical and neurological status

1991 • 563 citations

Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase.

1986 • 372 citations

Biochemistry of tryptophan in health and disease

1983 • 329 citations

Quinolinic acid is a potent lipid peroxidant in rat brain homogenates

1991 • 263 citations

Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse

1992 • 193 citations

3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims.

1988 • 186 citations

A mechanism for increased quinolinic acid formation following acute systemic immune stimulation

1993 • 181 citations

A mechanism of quinolinic acid formation by brain in inflammatory neurological disease: Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate

1993 • 167 citations

Mechanism of Delayed Increases in Kynurenine Pathway Metabolism in Damaged Brain Regions Following Transient Cerebral Ischemia

1993 • 164 citations

Inter-relationships between quinolinic acid, neuroactive kynurenines, neopterin and β2-microglobulin in cerebrospinal fluid and serum of HIV-1-infected patients

1992 • 136 citations

Possible Participation of Superoxide Anion in the Intestinal Tryptophan 2,3-Dioxygenase Reaction

1971 • 107 citations

Poliovirus induces indoleamine‐2,3‐dioxygenase and quinolinic acid synthesis in macaque brain

1992 • 98 citations

4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-γ-stimulated monocytes (THP-1 cells)

1993 • 97 citations

Presence of 3‐Hydroxyanthranilic Acid in Rat Tissues and Evidence for Its Production from Anthranilic Acid in the Brain

1990 • 74 citations

Regional brain and cerebrospinal fluid quinolinic acid concentrations in Huntington's disease

1991 • 69 citations

Metabolism of 6-chlorotryptophan to 4-chloro-3-hydroxyanthranilic acid: A potent inhibitor of 3-hydroxyanthranilic acid oxidase

1980 • 50 citations

Systemic Lipopolysaccharide and Pokeweed Mitogen Increase Quinolinic Acid Content of Mouse Cerebral Cortex

1988 • 41 citations

4-chloro-3-hydroxyanthranilate inhibits brain 3-hydroxyanthranate oxidase

1988 • 40 citations

Tryptophan metabolism via the kynurenine pathway in patients with the eosinophilia–Myalgia syndrome

1992 • 35 citations