Induction of Indoleamine 2,3-Dioxygenase in Tumor Cells Transplanted into Allogeneic Mouse: Interferon-γ is the Inducer

Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.

1984 • 847 citations

Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity.

1988 • 459 citations

Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells

1986 • 389 citations

Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase.

1986 • 372 citations

Induction of pulmonary indoleamine 2,3-dioxygenase by interferon.

1981 • 285 citations

Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.

1988 • 241 citations

Human indolylamine 2,3-dioxygenase. Its tissue distribution, and characterization of the placental enzyme

1985 • 237 citations

Induction of indoleamine 2,3-dioxygenase in mouse lung during virus infection.

1979 • 210 citations

Role of tryptophan degradation in respiratory burst-independent antimicrobial activity of gamma interferon-stimulated human macrophages

1989 • 201 citations

Interferon enhances tryptophan metabolism by inducing pulmonary indoleamine 2,3-dioxygenase: its possible occurrence in cancer patients.

1986 • 191 citations

Human macrophages degrade tryptophan upon induction by interferon-gamma

1987 • 182 citations

Induction of Tryptophan DegradationIn VitroandIn Vivo: A γ-Interferon-Stimulated Activity

1986 • 181 citations

Induction of pulmonary indoleamine 2,3-dioxygenase by intraperitoneal injection of bacterial lipopolysaccharide.

1978 • 172 citations

Characterization of an Indoleamine 2,3-Dioxygenase Induced by Gamma-Interferon in Cultured Human Fibroblasts

1986 • 158 citations

Biologic-response-modifier-induced indoleamine 2,3-dioxygenase activity in human peripheral blood mononuclear cell cultures.

1987 • 151 citations

Regulation of indoleamine 2,3-dioxygenase activity in the small intestine and the epididymis of mice

1980 • 112 citations

The actions of interferon and antiinflammatory agents on induction of indoleamine 2,3-dioxygenase in human peripheral blood monocytes

1987 • 97 citations

Tryptophan degradation in transplanted tumor cells undergoing rejection.

1988 • 80 citations

Dependence of the in vitro antiproliferative activity of recombinant human gamma-interferon on the concentration of tryptophan in culture media.

1988 • 71 citations

Indoleamine 2,3-dioxygenase. A new, rapid, sensitive radiometric assay and its application to the study of the enzyme in rat tissues

1980 • 54 citations

Specific induction of indoleamine 2,3-dioxygenase by bacterial lipopolysaccharide in the mouse lung

1981 • 54 citations

Interferon-γ-Induced Degradation of Tryptophan by Human Cells in vitro

1987 • 49 citations

Immune interferon induced by phytohemagglutinin in nude mouse spleen cells

1978 • 45 citations

Tryptophan reversal of recombinant human gamma-interferon inhibition ofChlamydia trachomatis growth

1987 • 34 citations

The Development of Antibody to the Interferon-Induced Indoleamine 2,3-Dioxygenase and the Study of the Regulation of Its Synthesis

1988 • 26 citations

Influence of interferon-gamma and extracellular tryptophan on indoleamine 2,3-dioxygenase activity in T24 cells as determined by a non-radiometric assay

1988 • 21 citations

Chromatographic Behavior, Purification, and Properties of Mouse BCG-induced Gamma Interferon

1982 • 5 citations