Regulation of the Kynurenine Pathway by IFN-γ in Murine Cloned Macrophages and Microglial Cells

Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity.

1988 • 459 citations

Human macrophages convert <scp>l</scp>-tryptophan into the neurotoxin quinolinic acid

1992 • 450 citations

Brain glia release factors with opposing actions upon neuronal survival

1993 • 437 citations

Monokine production by microglial cell clones

1989 • 366 citations

Origins of DNA replication in metazoan chromosomes.

1993 • 203 citations

A mechanism for increased quinolinic acid formation following acute systemic immune stimulation

1993 • 181 citations

A mechanism of quinolinic acid formation by brain in inflammatory neurological disease: Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate

1993 • 167 citations

Modulation of the Kynurenine Pathway in Search for New Neuroprotective Agents.Synthesis and Preliminary Evaluation of (m-Nitrobenzoyl)alanine, a Potent Inhibitor of Kynurenine-3-hydroxylase

1994 • 134 citations

Synthesis of Quinolinic Acid by 3‐Hydroxyanthranilic Acid Oxygenase in Rat Brain Tissue In Vitro

1986 • 124 citations

Brain macrophages: neurotoxic or neurotrophic effector cells?

1994 • 113 citations

4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-γ-stimulated monocytes (THP-1 cells)

1993 • 97 citations

Metabolism and neuropathologic significance of quinolinic acid and kynurenic acid

1993 • 47 citations

Mouse macrophage clones immortalized by retroviruses are functionally heterogeneous.

1991 • 38 citations

Cloning and Characterization of a Soluble Kynurenine Aminotransferase from Rat Brain: Identity with Kidney Cysteine Conjugate β‐Lyase

1995 • 37 citations

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