Mechanism of Delayed Increases in Kynurenine Pathway Metabolism in Damaged Brain Regions Following Transient Cerebral Ischemia

Delayed neuronal death in the gerbil hippocampus following ischemia

1982 • 2,856 citations

Temporal profile of neuronal damage in a model of transient forebrain ischemia

1982 • 2,695 citations

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1986 • 1,283 citations

Quinolinic Acid: An Endogenous Metabolite That Produces Axon-Sparing Lesions in Rat Brain

1983 • 1,247 citations

Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism

1991 • 1,018 citations

The density and distribution of ischemic brain injury in the rat following 2?10 min of forebrain ischemia

1984 • 968 citations

Blood–Brain Barrier Transport of Kynurenines: Implications for Brain Synthesis and Metabolism

1991 • 705 citations

Quinolinic acid in cerebrospinal fluid and serum in HIV‐1 Infection: Relationship to clinical and neurological status

1991 • 563 citations

II. Excitotoxic models for neurodegenerative disorders

1984 • 469 citations

Localization of 70-kDa stress protein induction in gerbil brain after ischemia

1988 • 465 citations

Human macrophages convert <scp>l</scp>-tryptophan into the neurotoxin quinolinic acid

1992 • 450 citations

Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid

1984 • 416 citations

Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase.

1986 • 372 citations

Biochemistry of tryptophan in health and disease

1983 • 329 citations

Immunocytochemical Study of an Early Microglial Activation in Ischemia

1992 • 301 citations

The Microglial Reaction in the Rat Dorsal Hippocampus following Transient Forebrain Ischemia

1991 • 301 citations

Delayed Demyelination and Macrophage Invasion: A Candidate for Secondary Cell Damage in Spinal Cord Injury

1985 • 295 citations

The effects of 5-minute ischemia in mongolian gerbils: I. Blood-brain barrier, cerebral blood flow, and local cerebral glucose utilization changes

1983 • 274 citations

Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors

1990 • 256 citations

Neurochemical Correlates to Selective Neuronal Vulnerability

1985 • 252 citations

The kinetics and morphological characteristics of the macrophage-microglial response to kainic acid-induced neuronal degeneration

1991 • 252 citations

Rat Brain Slices Produce and Liberate Kynurenic Acid upon Exposure to <scp>l</scp>‐Kynurenine

1989 • 221 citations

Ischemia triggers NMDA receptor-linked cytoskeletal proteolysis in hippocampus

1989 • 209 citations

Pharmacology and regional variations of quinolinic acid-evoked excitations in the rat central nervous system.

1983 • 209 citations

Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse

1992 • 193 citations

3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims.

1988 • 186 citations

Human macrophages degrade tryptophan upon induction by interferon-gamma

1987 • 182 citations

Major histocompatibility complex antigen expression on rat microglia following epidural kainic acid lesions

1988 • 162 citations

Progressive expression of immunomolecules on microglial cells in rat dorsal hippocampus following transient forebrain ischemia

1992 • 139 citations

Quantification of quinolinic acid in rat brain, whole blood, and plasma by gas chromatography and negative chemical ionization mass spectrometry: Effects of systemic l-tryptophan administration on brain and blood quinolinic acid concentrations

1988 • 126 citations

Neuroactive kynurenines in Lyme borreliasis

1992 • 125 citations

Brain Quinolinic Acid in Huntington's Disease

1988 • 111 citations

Determination of serum kynurenine and hepatic tryptophan dioxygenase activity by high-performance liquid chromatography

1988 • 111 citations

Cerebrospinal fluid levels of quinolinic acid in Huntington's disease and schizophrenia

1988 • 105 citations

Poliovirus induces indoleamine‐2,3‐dioxygenase and quinolinic acid synthesis in macaque brain

1992 • 98 citations

Indoleamine 2,3-dioxygenase. Potassium superoxide as substrate.

1977 • 98 citations

Relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acid

1992 • 95 citations

The origin of lipid phagocytes in the central nervous system: I. The intrinsic microglia

1982 • 86 citations

Distribution of ischemic neuronal damage in the dorsal hippocampus of rat

1988 • 84 citations

Increased Cerebrospinal Fluid Quinolinic Acid, Kynurenic Acid, and L‐Kynurenine in Acute Septicemia

1990 • 80 citations

Chronic effects of γ-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice

1991 • 80 citations

Rat 3‐Hydroxyanthranilic Acid Oxygenase: Purification from the Liver and Immunocytochemical Localization in the Brain

1987 • 80 citations

Changes in the concentrations of cerebral proteins following occlusion of the middle cerebral artery in rats.

1990 • 78 citations

Systemic endotoxin increasesl-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid content of mouse cerebral cortex

1989 • 76 citations

Quantification of 3-hydroxykynurenine in brain by high-performance liquid chromatography and electrochemical detection

1988 • 75 citations

Increased ratio of quinolinic acid to kynurenic acid in cerebrospinal fluid of D retrovirus—infected rhesus macaques: Relationship to clinical and viral status

1990 • 73 citations

Quinolinic Acid Phosphoribosyltransferase in Rat Brain

1985 • 72 citations

Regional brain and cerebrospinal fluid quinolinic acid concentrations in Huntington's disease

1991 • 69 citations

Hypothesis: A Role for Quinolinic Acid in the Neuropathology of Glutaric Aciduria Type I

1987 • 69 citations

Cell proliferation after ischemic injury in gerbil brain

1985 • 66 citations

Delayed Increases in Regional Brain Quinolinic Acid Follow Transient Ischemia in the Gerbil

1990 • 59 citations

Macrophages in Solid Tumors. I. Immunologically Specific Effector Cells 2

1974 • 54 citations

Quantification of kynurenic acid in cerebrospinal fluid: effects of systemic and central l-kynurenine administration

1990 • 54 citations

Cerebral cortex and lung indoleamine-2,3-dioxygenase activity is increased in type-D retrovirus infected macaques

1991 • 49 citations

Actions of excitatory amino acids and kynurenic acid in the primate hippocampus: A preliminary study

1984 • 48 citations

(18O)quinolinic acid: Its esterification without back exchange for use as internal standard in the quantification of brain and CSF quinolinic acid

1988 • 47 citations

Production of extracellular quinolinic acid in the striatum studied by microdialysis in unanesthetized rats

1989 • 44 citations

Systemic Lipopolysaccharide and Pokeweed Mitogen Increase Quinolinic Acid Content of Mouse Cerebral Cortex

1988 • 41 citations

4-chloro-3-hydroxyanthranilate inhibits brain 3-hydroxyanthranate oxidase

1988 • 40 citations

The origin of lipid phagocytes in the central nervous system: II. The adventitia of blood vessels

1982 • 39 citations

Increased quinolinic acid metabolism following neuronal degeneration in the rat hippocampus

1987 • 33 citations

Cell proliferation after ischemic infarction in gerbil brain

1985 • 28 citations

Neurotoxicity of Tryptophan Metabolites

1990 • 16 citations

Neurological Infections

1989 • 12 citations