Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types

QUINOLINIC ACID AND KYNURENINE PATHWAY METABOLISM IN INFLAMMATORY AND NON-INFLAMMATORY NEUROLOGICAL DISEASE

1992 • 655 citations

Quinolinic acid in cerebrospinal fluid and serum in HIV‐1 Infection: Relationship to clinical and neurological status

1991 • 563 citations

Human macrophages convert <scp>l</scp>-tryptophan into the neurotoxin quinolinic acid

1992 • 450 citations

Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase.

1986 • 372 citations

Biochemistry of tryptophan in health and disease

1983 • 329 citations

Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse

1992 • 193 citations

A mechanism for increased quinolinic acid formation following acute systemic immune stimulation

1993 • 181 citations

A mechanism of quinolinic acid formation by brain in inflammatory neurological disease: Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate

1993 • 167 citations

Mechanism of Delayed Increases in Kynurenine Pathway Metabolism in Damaged Brain Regions Following Transient Cerebral Ischemia

1993 • 164 citations

Interferons and indoleamine 2,3-dioxygenase: Role in antimicrobial and antitumor effects

1989 • 139 citations

Quantification of quinolinic acid in rat brain, whole blood, and plasma by gas chromatography and negative chemical ionization mass spectrometry: Effects of systemic l-tryptophan administration on brain and blood quinolinic acid concentrations

1988 • 126 citations

Kynurenine Pathway Enzymes in Brain: Responses to Ischemic Brain Injury Versus Systemic Immune Activation

1993 • 116 citations

Determination of serum kynurenine and hepatic tryptophan dioxygenase activity by high-performance liquid chromatography

1988 • 111 citations

Poliovirus induces indoleamine‐2,3‐dioxygenase and quinolinic acid synthesis in macaque brain

1992 • 98 citations

4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-γ-stimulated monocytes (THP-1 cells)

1993 • 97 citations

Quantification of Local De Novo Synthesis Versus Blood Contributions to Quinolinic Acid Concentrations in Brain and Systemic Tissues

1997 • 78 citations

Quantification of 3-hydroxykynurenine in brain by high-performance liquid chromatography and electrochemical detection

1988 • 75 citations

The preferred route of kynurenine metabolism in the rat

1982 • 74 citations

Human Fetal Astrocytes in Culture Support the Growth of the Neurotropic Human Polyomavirus, JCV

1989 • 55 citations

Early appearance of type II astrocytes in developing human fetal brain

1988 • 54 citations

Kynurenine 3-Hydroxylase in Brain: Species Activity Differences and Effect of Gerbil Cerebral Ischemia

1993 • 36 citations

Metabolism of <scp>l</scp>‐Tryptophan to Kynurenate and Quinolinate in the Central Nervous System: Effects of 6‐Chlorotryptophan and 4‐Chloro‐3‐Hydroxyanthranilate

1995 • 27 citations