Involvement of hippocampal synaptic plasticity in age-related memory decline

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex

1982 • 2,824 citations

Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.

1979 • 1,970 citations

Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.

1992 • 1,675 citations

Life and Death of Neurons in the Aging Brain

1997 • 1,323 citations

A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.

1989 • 1,114 citations

Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus

1992 • 1,088 citations

Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression

1994 • 1,063 citations

Age‐associated memory impairment: Proposed diagnostic criteria and measures of clinical change — report of a national institute of mental health work group

1986 • 928 citations

Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.

1993 • 901 citations

Long-term depression of excitatory synaptic transmission and its relationship to long-term potentiation

1993 • 780 citations

An Essential Role for Protein Phosphatases in Hippocampal Long-Term Depression

1993 • 678 citations

Regulation of NMDA receptors by tyrosine kinases and phosphatases

1994 • 671 citations

The Use of the Morris Water Maze in the Study of Memory and Learning

1989 • 665 citations

Bidirectional synaptic plasticity induced by a single burst during cholinergic theta oscillation in CA1 in vitro

1995 • 634 citations

Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus

1993 • 590 citations

Long-Term Depression in Hippocampus

1996 • 583 citations

Synapses as associative memory elements in the hippocampal formation

1979 • 573 citations

Senescent forgetfulness: benign and malignant.

1962 • 565 citations

Long-term potentiation phenomena in the rat limbic forebrain

1983 • 562 citations

Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway

1999 • 561 citations

Storing covariance with nonlinearly interacting neurons

1977 • 558 citations

Persistent protein kinase activity underlying long-term potentiation

1988 • 557 citations

Properties of two calcium‐activated hyperpolarizations in rat hippocampal neurones.

1987 • 554 citations

Modulation of AMPA receptor unitary conductance by synaptic activity

1998 • 531 citations

Visuo-spatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalo-hippocampectomy in man

1995 • 531 citations

CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP

1995 • 530 citations

The role of interactions between the cholinergic system and other neuromodulatory systems in learing and memory

1991 • 525 citations

Spatial learning and motor deficits in aged rats

1984 • 509 citations

Learning and memory in normal aging

1994 • 503 citations

Long-Term Synaptic Depression

1995 • 493 citations

Increase in Single L-Type Calcium Channels in Hippocampal Neurons During Aging

1996 • 488 citations

Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization.

1994 • 488 citations

Regulation of NMDA channel function by endogenous Ca2+-dependent phosphatase

1994 • 483 citations

Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism.

1995 • 451 citations

Stress: metaplastic effects in the hippocampus

1998 • 414 citations

Calcium Hypothesis of Alzheimer's Disease and Brain Aging^a

1994 • 376 citations

Hippocampal synaptic plasticity: role in spatial learning or the automatic recording of attended experience?

1997 • 359 citations

An evaluation of spatial information processing in aged rats.

1987 • 353 citations

An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses.

1985 • 334 citations

Normal aging: regionally specific changes in hippocampal synaptic transmission

1994 • 332 citations

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein

1997 • 331 citations

Hippocampal markers of age-related memory dysfunction: Behavioral, electrophysiological and morphological perspectives

1995 • 318 citations

Conditioning-specific membrane changes of rabbit hippocampal neurons measured in vitro.

1986 • 318 citations

Age-related spatial reference and working memory deficits assessed in the water maze

1995 • 314 citations

Nimodipine Facilitates Associative Learning in Aging Rabbits

1989 • 305 citations

MOLECULAR GENETIC ANALYSIS OF SYNAPTIC PLASTICITY, ACTIVITY-DEPENDENT NEURAL DEVELOPMENT, LEARNING, AND MEMORY IN THE MAMMALIAN BRAIN

1997 • 299 citations

Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats

1978 • 298 citations

Correlations between immediate early gene induction and the persistence of long-term potentiation

1993 • 297 citations

Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age- and concentration-dependent manner

1992 • 293 citations

Increased Susceptibility to Induction of Long-Term Depression and Long-Term Potentiation Reversal during Aging

1996 • 286 citations

Physiological compensation for loss of afferent synapses in rat hippocampal granule cells during senescence.

1980 • 285 citations

Activity-Dependent β-Adrenergic Modulation of Low Frequency Stimulation Induced LTP in the Hippocampal CA1 Region

1996 • 282 citations

Patch clamp studies on the kinetics and selectivity of N-methyl-d-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan)

1993 • 278 citations

Reversal of Age-Related Alterations in Synaptic Plasticity by Blockade of L-Type Ca²⁺Channels

1998 • 275 citations

An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses.

1985 • 275 citations

Apical Dendritic Location of Slow Afterhyperpolarization Current in Hippocampal Pyramidal Neurons: Implications for the Integration of Long-Term Potentiation

1996 • 260 citations

Possible mechanisms for atrophy of the human hippocampus

1997 • 239 citations

Transient changes in excitability of rabbit CA3 neurons with a time course appropriate to support memory consolidation

1996 • 237 citations

Noradrenergic Regulation of Synaptic Plasticity in the Hippocampal CA1 Region

1997 • 235 citations

Block of LTP in rat hippocampus in vivo by β-amyloid precursor protein fragments

1997 • 233 citations

Calcium and neuronal ageing

1998 • 228 citations

Aging Differentially Alters Forms of Long-Term Potentiation in Rat Hippocampal Area CA1

1998 • 218 citations

Age-related alterations in potentiation in the CA1 region in F344 rats

1993 • 216 citations

The role of calcium regulation in brain aging: reexamination of a hypothesis

1989 • 211 citations

Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A

1994 • 210 citations

Aging Changes in Voltage-Gated Calcium Currents in Hippocampal CA1 Neurons

1996 • 197 citations

Age-associated changes in Ca2+-dependent processes: Relation to hippocampal synaptic plasticity

1997 • 195 citations

Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation

1998 • 194 citations

Calcium-related damage in ischemia

1996 • 193 citations

Calcium-dependent afterhyperpolarization and learning in young and aging hippocampus

1996 • 189 citations

Two forms of long-term potentiation in area CA1 activate different signal transduction cascades

1996 • 188 citations

NMDA receptor antagonists can enhance or impair learning performance in animals

1989 • 184 citations

Delay-dependent short-term memory deficits in aged rats

1988 • 183 citations

Impaired Monosynaptic Potentiation in in Vitro Hippocampal Slices From Aged, Memory-deficient Rats

1977 • 181 citations

Hippocampus-dependent learning facilitated by a monoclonal antibody or D-cycloserine

1992 • 180 citations

Altered synaptic transmission in dentate gyrus of rats reared in complex environments: evidence from hippocampal slices maintained in vitro

1986 • 179 citations

Postsynaptic injection of Ca2+/CaM induces synaptic potentiation requiring CaMKII and PKC activity

1995 • 178 citations

Reliability, Distribution, and Validity of Age-Related Cognitive Deficits in the Morris Water Maze

1997 • 177 citations

Calcium dysregulation in neuronal aging and Alzheimer's disease: history and new directions

1998 • 173 citations

Secreted form of β-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices

1997 • 171 citations

Hippocampal plasticity induced by primed burst, but not long‐term potentiation, stimulation is impaired in area CA1 of aged fischer 344 rats

1993 • 170 citations

D1/D5 Dopamine Receptors Inhibit Depotentiation at CA1 Synapses via cAMP-Dependent Mechanism

1998 • 167 citations

The effects of high Mg2+-to-Ca2+ ratios on frequency potentiation in hippocampal slices of young and aged rats

1986 • 158 citations

Region‐specific age effects on AMPA sensitivity: Electrophysiological evidence for loss of synaptic contacts in hippocampal field CA1

1992 • 158 citations

Bidirectional Regulation of Protein Kinase Mζ in the Maintenance of Long-Term Potentiation and Long-Term Depression

1996 • 157 citations

Memory for pictures: Does an age-related decline exist?

1986 • 152 citations

Aged rats need a preserved complement of perforated axospinous synapses per hippocampal neuron to maintain good spatial memory

1986 • 149 citations

Spatial memory is related to hippocampal subcellular concentrations of calcium-dependent protein kinase C isoforms in young and aged rats

1997 • 149 citations

Effects of the Uncompetitive NMDA Receptor Antagonist Memantine on Hippocampal Long‐term Potentiation, Short‐term Exploratory Modulation and Spatial Memory in Awake, Freely Moving Rats

1996 • 145 citations

Age-related impairments in spatial memory are independent of those in sensorimotor skills

1989 • 140 citations

Phosphorylation of presynaptic and postsynaptic calcium channels by cAMP-dependent protein kinase in hippocampal neurons.

1995 • 138 citations

Hippocampal neurobiological mechanisms of age-related memory dysfunction

1988 • 138 citations

Kinase and phosphatase activities intimately associated with a reconstituted calcium-dependent potassium channel

1995 • 131 citations

Rapid forgetting in aged rats

1982 • 130 citations

Cholinergic neurotransmission and synaptic plasticity concerning memory processing.

1997 • 130 citations

Priming of long-term potentiation induced by activation of metabotropic glutamate receptors coupled to phospholipase C

1998 • 130 citations

Aging-related prolongation of calcium spike duration in rat hippocampal slice neurons

1990 • 128 citations

Spatial performance correlates with in vitro potentiation in young and aged Fischer 344 rats

1991 • 127 citations

Mechanism of altered synaptic strength due to experience: relation to long-term potentiation

1996 • 127 citations

Ionic effects of the Alzheimer's disease β-amyloid precursor protein and its metabolic fragments

1997 • 124 citations

Dopamine modulates the slow Ca(2+)-activated K+ current IAHP via cyclic AMP-dependent protein kinase in hippocampal neurons

1995 • 123 citations

D-cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats

1994 • 123 citations

N-methyl-d-aspartate receptor-independent long-term potentiation in area CA1 of rat hippocampus: Input-specific induction and preclusion in a non-tetanized pathway

1992 • 116 citations

Memory for pictures: Does an age-related decline exist?

1986 • 114 citations

The nitric oxide hypothesis of brain aging

1997 • 113 citations

Life-span changes in implicit and explicit memory

1990 • 113 citations

Episodic spatial memory in adulthood.

1993 • 112 citations

Age-related deficits on the radial maze and in fear conditioning: Hippocampal processing and consolidation

1998 • 112 citations

A role for protein kinases and phosphatases in the Ca2+-induced enhancement of hippocampal AMPA receptor-mediated synaptic responses

1994 • 106 citations

Increase in perforant path quantal size in aged F-344 rats

1991 • 105 citations

Alterations in the Balance of Protein Kinase/Phosphatase Activities Parallel Reduced Synaptic Strength During Aging

1998 • 105 citations

Effects of aging on spatial learning and hippocampal protein kinase c in mice

1993 • 103 citations

Dissociations between procedural and episodic memory: Effects of time and aging.

1990 • 102 citations

Recognition memory of spatial location information: Another failure to support automaticity

1988 • 99 citations

Episodic spatial memory in adulthood.

1993 • 99 citations

LTP, NMDA, genes and learning

1997 • 99 citations

Functional integrity of NMDA-dependent LTP induction mechanisms across the lifespan of F-344 rats.

1996 • 99 citations

Nimodipine decreases calcium action potentials in rabbit hippocampal CA1 neurons in an age‐dependent and concentration‐dependent manner

1994 • 97 citations

Age-related decrease in cholinergic synaptic transmission in three hippocampal subfields

1996 • 97 citations

Metabotropic glutamate receptors coupled to IP3 production mediate inhibition of IAHP in rat dentate granule neurons

1996 • 96 citations

Channels underlying the slow afterhyperpolarization in hippocampal pyramidal neurons: neurotransmitters modulate the open probability

1995 • 95 citations

Behavioral Assessment of the Senescence-accelerated Mouse (SAM P8 and R1)

1998 • 87 citations

Apamin improves learning in an object recognition task in rats

1997 • 87 citations

Rate of forgetting in mild Alzheimer's-type dementia

1988 • 87 citations

Central Neurotransmitter Substances and Aging: A Review

1977 • 86 citations

5-Hydroxytryptamine4 receptors reduce afterhyperpolarization in hippocampus by inhibiting calcium-induced calcium release.

1996 • 81 citations

In vitro autoradiography of hippocampal excitatory amino acid binding in aged Fischer 344 rats: Relationship to performance on the Morris water maze.

1992 • 80 citations

Contribution of Voltage-Gated Ca²⁺ Channels to Homosynaptic Long-Term Depression in the CA1 Region In Vitro

1997 • 79 citations

Short forms of the “reference-” and “working-memory” Morris water maze for assessing age-related deficits

1992 • 79 citations

β-amyloid-(1–40) increases long-term potentiation in rat hippocampus in vitro

1995 • 78 citations

Aging and cognition: Facilitation of recent memory in aged nonhuman primates by nimodipine

1990 • 77 citations

Differential Modulation of Synaptic Transmission by Calcium Chelators in Young and Aged Hippocampal CA1 Neurons: Evidence for Altered Calcium Homeostasis in Aging

1999 • 76 citations

Modulation of the Ca²⁺-Activated K⁺Current sI_AHPby aPhosphatase-Kinase Balance Under Basal Conditions inRat CA1 Pyramidal Neurons

1998 • 76 citations

Nimodipine enhances spontaneous activity of hippocampal pyramidal neurons in aging rabbits at a dose that facilitates associative learning

1990 • 76 citations

Chronically elevating plasma Mg2+ improves hippocampal frequency potentiation and reversal learning in aged and young rats

1984 • 75 citations

Relationship between performance in the morris water task, visual acuity, and thermoregulatory function in aged F-344 rats

1991 • 75 citations

Dissociations between procedural and episodic memory: Effects of time and aging.

1990 • 74 citations

Age dependent changes in retention in rats I

1982 • 74 citations

Transient and persistent increases in protein phosphatase activity during long-term depression in the adult hippocampus in vivo

1998 • 73 citations

Enhanced Synaptic Transmission in CA1 Hippocampus After Eyeblink Conditioning

1997 • 73 citations

The duration of long-term potentiation in the CA1 region of the hippocampal slice preparation

1985 • 68 citations

Rates of forgetting in normal ageing: A comparison with dementia

1989 • 68 citations

In vitro autoradiography of hippocampal excitatory amino acid binding in aged Fischer 344 rats: Relationship to performance on the Morris water maze.

1992 • 67 citations

Age and strain differences in rat place learning and hippocampal dentate gyrus frequency-potentiation

1994 • 66 citations

β-Amyloid produces a delayed NMDA receptor- dependent reduction in synaptic transmission in rat hippocampus

1996 • 66 citations

The neurochemical and behavioral effects of β-amyloid peptide(25–35)

1996 • 65 citations

L-Type Voltage-Dependent Calcium Channel Blocker Nifedipine Enhances Memory Retention When Infused into the Hippocampus

1998 • 64 citations

Old age and cognition: Enhancement of recent memory in aged rats by the calcium channel blocker nimodipine

1992 • 61 citations

Age and Stress History Effects on Spatial Performance in a Swim Task in Fischer-344 Rats

1996 • 58 citations

Increased Hippocampal Ca²⁺ Channel Activity in Brain Aging and Dementia

1994 • 58 citations

A neuropsychological analysis of memory loss with age

1988 • 57 citations

Behavioral and Neuropathologic Changes Induced by Central Injection of Carboxyl‐Terminal Fragment of β‐Amyloid Precursor Protein in Mice

1998 • 56 citations

Intrahippocampal Injections of Exogenous β-Amyloid Induce Postdelay Errors in an Eight-Arm Radial Maze

1997 • 56 citations

Protein kinase and phosphatase activity regulate the form of synaptic plasticity expressed

1996 • 56 citations

Age- and dose-dependent facilitation of associative eyeblink conditioning by D-cycloserine in rabbits.

1997 • 55 citations

Hippocampal Cell Death

1996 • 55 citations

Glycine site associated with the NMDA receptor modulates long‐term potentiation

1990 • 54 citations

Young and older adults' use of context in spatial memory.

1988 • 54 citations

Proactive interference effects on short-term memory in rats: II. Effects in young and aged rats.

1990 • 52 citations

Enhanced acquisition of reversal training in a spatial learning task in rats treated with chronic nimodipine

1993 • 50 citations

β-Adrenergic Stimulation Selectively Inhibits Long-Lasting L-Type Calcium Channel Facilitation in Hippocampal Pyramidal Neurons

1997 • 49 citations

Effects of aging on environmental modulation of hippocampal evoked responses.

1987 • 49 citations

New Pharmacological Strategies for Cognitive Enhancement Using a Rat Model of Age-Related Memory Impairment

1994 • 49 citations

MK-801 Improves Retention in Aged Rats: Implications for Altered Neural Plasticity in Age-Related Memory Deficits

1999 • 49 citations

Adult age differences in forgetting sentences.

1993 • 48 citations

Evidence that Ca/calmodulin-dependent protein kinase mediates the modulation of the Ca 2+ -dependent K + current, I AHP , by acetylcholine, but not by glutamate, in hippocampal neurons

1996 • 48 citations

Enhancement of AMPA‐mediated Synaptic Transmission by the Protein Phosphatase Inhibitor Calyculin A in Rat Hippocampal Slices

1993 • 48 citations

Reduced hippocampal CA1 Ca2+-induced long-term potentiation is associated with age-dependent impairment of spatial learning

1995 • 45 citations

Proactive interference effects on short-term memory in rats: II. Effects in young and aged rats.

1990 • 45 citations

Insensitivity of the Hippocampus to Environmental Stimulation during Postnatal Development

1997 • 45 citations

Forgetting of pictures over a long retention interval in young and older adults.

1988 • 42 citations

Selective reduction of hippocampal dentate frequency potentiation in aged rats with impaired place learning

1994 • 42 citations

Hippocampal Cell Death

1996 • 42 citations

Age-related reduction in responses of rat hippocampal neurons to locally applied monoamines

1988 • 41 citations

Adenosine A3 Receptors Potentiate Hippocampal Calcium Current by a PKA-dependent/PKC-independent Pathway

1997 • 40 citations

Tyrosine kinase inhibitors enhance a Ca(2+)‐activated K+ current (IAHP) and reduce IAHP suppression by a metabotropic glutamate receptor agonist in rat dentate granule neurones.

1996 • 38 citations

Young and older adults' use of context in spatial memory.

1988 • 36 citations

Intraseptal infusions of a low dose of AP5, a NMDA receptor antagonist, improves memory in an object recognition task in rats

1998 • 35 citations

Electrophysiological changes in rat hippocampal pyramidal neurons produced by cholecystokinin octapeptide

1997 • 34 citations

Assessment of retention capacities in old rats

1983 • 34 citations

Effect of apamin, a selective blocker of Ca2+-activated K+-channel, on habituation and passive avoidance responses in rats

1997 • 33 citations

Cognition and Hippocampal Systems in Aging:Animal Models

1995 • 32 citations

Post-test apamin injection suppresses a Kamin-like effect following a learning session in mice

1995 • 31 citations

Forgetting of pictures over a long retention interval in young and older adults.

1988 • 30 citations

Nimodipine facilitates retention of the classically conditioned nictitating membrane response in aged rabbits over long retention intervals

1995 • 30 citations

Behavioral assessment of forgetting in aged rodents and its relationship to peripheral sympathetic function

1988 • 30 citations

Adult age differences in forgetting sentences.

1993 • 30 citations

Adult age differences in spatial memory: Effects of structural context and practice

1993 • 29 citations

Synaptic plasticity in the dentate gyrus of aged rats is altered after chronic nimodipine application

1992 • 29 citations

Tetrahydroaminoacridine and d-cycloserine stimulate acquisition of water maze spatial navigation in aged rats

1998 • 26 citations

Evidence that Ca/calmodulin-dependent protein kinase mediates the modulation of the Ca2+-dependent K+ current,I AHP, by acetylcholine, but not by glutamate, in hippocampal neurons

1996 • 26 citations

Uncoupling of muscarinic cholinergic phosphoinositide signals in senescent cerebral cortical and hippocampal membranes

1998 • 23 citations

An adult developmental study of the encoding of spatial location

1992 • 23 citations

Cytosolic hippocampal PKC and aging

1998 • 19 citations

Intrahippocampal injections of the beta-amyloid 1-28 fragment induces behavioral deficits in rats.

1997 • 17 citations

Effects of aging and chronic nimodipine on hippocampal binding of [3H]CGS 19755

1996 • 12 citations

Neuronal membrane conductance activated by amyloid β peptide: importance of peptide conformation

1995 • 11 citations

Kinetics of Muscarinic Reduction of I _sAHP in Hippocampal Neurons: Effects of Acetylcholinesterase Inhibitors

1997 • 9 citations

Structural‐Functional Correlates of Neuroprotection in the Aging Rabbit by a Calcium Channel Blocker. Nimodipine Reverses Neocortical Dendritic Atrophy and Improves Memory Retention^a

1995 • 9 citations

The memory-facilitating effects of the competitive NMDA-receptor antagonist CGP 37849 are steroid-sensitive, whereas its memory-impairing effects are not

1996 • 9 citations

Preface

1994 • 5 citations

Entorhinal cortex lesions as a model of age-related changes in hippocampal function

1997 • 5 citations