Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway
Data up to Jan 2025
Total Citations Per Year
Abstract
References (42)
Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.
1979 • 1,970 citations
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
1994 • 1,802 citations
Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory
1997 • 1,228 citations
Effects of cAMP Simulate a Late Stage of LTP in Hippocampal CA1 Neurons
1993 • 1,212 citations
Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP
1994 • 889 citations
Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro
1988 • 800 citations
Preserved neuron number in the hippocampus of aged rats with spatial learning deficits.
1996 • 635 citations
Regionally specific loss of neurons in the aging human hippocampus
1993 • 612 citations
Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence
1991 • 598 citations
Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats
1997 • 500 citations
Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization.
1994 • 488 citations
Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal ltp in the range of the θ frequency
1995 • 464 citations
Long-Term Potentiation Is Reduced in Mice That Are Doubly Mutant in Endothelial and Neuronal Nitric Oxide Synthase
1996 • 436 citations
Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory
1998 • 431 citations
Cellular neurophysiological approaches in the study of learning.
1968 • 403 citations
Multistability of cognitive maps in the hippocampus of old rats
1997 • 355 citations
Hippocampal markers of age-related memory dysfunction: Behavioral, electrophysiological and morphological perspectives
1995 • 318 citations
Novel dopamine receptors half a decade later
1995 • 296 citations
Individual differences in the cognitive and neurobiological consequences of normal aging
1992 • 287 citations
Increased Susceptibility to Induction of Long-Term Depression and Long-Term Potentiation Reversal during Aging
1996 • 286 citations
Long-lasting forms of synaptic potentiation in the mammalian hippocampus.
1996 • 222 citations
Aging Differentially Alters Forms of Long-Term Potentiation in Rat Hippocampal Area CA1
1998 • 218 citations
Age-related alterations in potentiation in the CA1 region in F344 rats
1993 • 216 citations
Memory Deficits in Aged Cebus Monkeys and Facilitation With Central Cholinomimetics
1980 • 170 citations
Spatial memory deficits in aged rats: contributions of monoaminergic systems
1990 • 167 citations
Spatial and Temporal Memory in 20 and 60 Year Olds
1981 • 148 citations
Brain Aging: Impaired Coding of Novel Environmental Cues
1997 • 124 citations
Role of temporal summation in age-related long-term potentiation-induction deficits
1997 • 121 citations
Dopamine D1, receptor ligands modulate cognitive performance and hippocampal acetylcholine release in memory-impaired aged rats
1995 • 119 citations
Episodic spatial memory in adulthood.
1993 • 112 citations
An age-related spatial learning deficit: Choline uptake distinguishes “impaired” and “unimpaired” rats
1988 • 108 citations
Episodic spatial memory in adulthood.
1993 • 99 citations
Neurobiological substrates of behavioral decline: Models and data analytic strategies for individual differences in aging
1996 • 79 citations
Alterations of cAMP response element-binding activity in the aged rat brain in response to administration of rolipram, a cAMP-specific phosphodiesterase inhibitor
1996 • 68 citations
Age-related changes in dopaminergic and serotonergic indices in the rat forebrain
1989 • 61 citations
Memory impairment during prolonged training in mice given inhibitors of cerebral protein synthesis
1973 • 60 citations
Local modulation of hippocampal acetylcholine release by dopamine D1 receptors: a combined receptor autoradiography and in vivo dialysis study
1995 • 54 citations
Preservation and loss of spatial memory in aged rats and humans: Implications for the analysis of memory dysfunction in dementia
1988 • 32 citations
Is Binding to Nicotinic Acetylcholine and Dopamine Receptors Related to Working Memory in Rats?
1997 • 31 citations
Cyclic AMP‐Mediated Enhancement of High‐Affinity Choline Transport and Acetylcholine Synthesis in Brain
1997 • 22 citations
Influence of Aging on Rolipram-Sensitive Phosphodiesterase Activity and (3H)Rolipram Binding in the Rat Brain.
1996 • 19 citations
Tryptophan Feeding Induces Sensitivity to Short Daylengths in Photoref ractory Hamsters
1983 • 10 citations