Normal aging: regionally specific changes in hippocampal synaptic transmission

Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.

1992 • 5,156 citations

Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.

1979 • 1,970 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path

1973 • 1,140 citations

On the role of the hippocampus in learning and memory in the rat

1993 • 1,116 citations

Development of Epileptic Seizures through Brain Stimulation at Low Intensity

1967 • 854 citations

Synaptic enhancement in fascia dentata: Cooperativity among coactive afferents

1978 • 665 citations

Regionally specific loss of neurons in the aging human hippocampus

1993 • 612 citations

Prolonged Ca ²⁺ -Dependent Afterhyperpolarizations in Hippocampal Neurons of Aged Rats

1984 • 489 citations

Intrahippocampal Septal Grafts Ameliorate Learning Impairments in Aged Rats

1984 • 369 citations

Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats

1978 • 298 citations

Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age- and concentration-dependent manner

1992 • 293 citations

The transverse hippocampal slice: a well-defined cortical structure maintainedin vitro

1971 • 288 citations

Individual differences in the cognitive and neurobiological consequences of normal aging

1992 • 287 citations

Physiological compensation for loss of afferent synapses in rat hippocampal granule cells during senescence.

1980 • 285 citations

Corticosteroid Modulation of Hippocampal Potentials: Increased Effect with Aging

1989 • 274 citations

Brain cholinergic dysfunction and memory in aged rats

1980 • 257 citations

Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging

1991 • 255 citations

Age‐related differences in brain electrical activity of healthy subjects

1984 • 255 citations

Individual differences in aging: Behavioral and neurobiological correlates

1989 • 254 citations

Postnatal handling attenuates certain neuroendocrine, anatomical, and cognitive dysfunctions associated with aging in female rats

1991 • 251 citations

Age‐related loss of axospinous synapses formed by two afferent systems in the rat dentate gyrus as revealed by the unbiased stereological dissector technique

1992 • 248 citations

Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys

1991 • 234 citations

Potentiation of monosynaptic EPSPs in the perforant path-dentate granule cell synapse

1971 • 233 citations

Frequency analysis of the resting awake EEG in mild senile dementia of Alzheimer type

1983 • 225 citations

Age-related alterations in potentiation in the CA1 region in F344 rats

1993 • 216 citations

Age-related decreases of the N-methyl-d-aspartate receptor complex in the rat cerebral cortex and hippocampus

1991 • 212 citations

Age-dependent alterations in hippocampal synaptic plasticity: Relation to memory disorders

1988 • 204 citations

‘Increased calcium-current’ hypothesis of brain aging

1987 • 192 citations

Impaired Monosynaptic Potentiation in in Vitro Hippocampal Slices From Aged, Memory-deficient Rats

1977 • 181 citations

Synaptic efficacy and EPSP summation in granule cells of rat fascia dentata studied in vitro.

1981 • 180 citations

Hippocampal plasticity induced by primed burst, but not long‐term potentiation, stimulation is impaired in area CA1 of aged fischer 344 rats

1993 • 170 citations

Age-related alterations in neurotransmitter receptors: An electrophysiological and biochemical analysis

1981 • 167 citations

Region‐specific age effects on AMPA sensitivity: Electrophysiological evidence for loss of synaptic contacts in hippocampal field CA1

1992 • 158 citations

The effects of high Mg2+-to-Ca2+ ratios on frequency potentiation in hippocampal slices of young and aged rats

1986 • 158 citations

The EEG in the normal elderly: a contribution to the interpretation of aging and dementia

1986 • 133 citations

Neural Plasticity: A Lifespan Approach

1988 • 131 citations

Aging-related prolongation of calcium spike duration in rat hippocampal slice neurons

1990 • 128 citations

Spatial performance correlates with in vitro potentiation in young and aged Fischer 344 rats

1991 • 127 citations

Decrease in the number of synapses in the senescent brain: A quantitative electron microscopic analysis of the dentate gyrus molecular layer in the rat

1976 • 119 citations

Alterations in the properties of hippocampal pyramidal neurons in the aged rat

1992 • 112 citations

Age-dependent deficits in spatial memory are related to impaired hippocampal kindling.

1984 • 111 citations

An age-related spatial learning deficit: Choline uptake distinguishes “impaired” and “unimpaired” rats

1988 • 108 citations

Increase in perforant path quantal size in aged F-344 rats

1991 • 105 citations

Increased electrotonic coupling in aged rat hippocampus: A possible mechanism for cellular excitability changes

1987 • 98 citations

Age-dependent deficits in spatial memory are related to impaired hippocampal kindling.

1984 • 95 citations

The pattern of age-related differences in electrophysiological activity of healthy males and females

1993 • 93 citations

Synaptic vesicle redistribution during hippocampal frequency potentiation and depression in young and aged rats

1988 • 92 citations

EEG amplitudes in healthy, late-middle-aged and elderly adults: normality of the distributions and correlations with age

1990 • 87 citations

Electroencephalogram in the Septuagenarian: Studies in a Normal Geriatric Population

1982 • 86 citations

Acetylcholine storage, release and leakage at the neuromuscular junction of mature adult and aged rats.

1984 • 85 citations

NMDA depolarizations and long-term potentiation are reduced in the aged rat neocortex

1990 • 81 citations

Chronically elevating plasma Mg2+ improves hippocampal frequency potentiation and reversal learning in aged and young rats

1984 • 75 citations

Functional Aspects of Calcium-Channel Modulation

1993 • 72 citations

Age-impaired impulse flow from nucleus basalis to cortex

1985 • 70 citations

Changes in neurotransmitter actions in the aged rat hippocampus

1982 • 70 citations

Age-related alterations in the properties of hippocampal pyramidal neurons among rat strains

1993 • 65 citations

Behavioral correlates of theta-on and theta-off cells recorded from hippocampal formation of mature young and aged rats

1990 • 65 citations

Synapse formation occurs in association with the induction of long-term potentiation in two-year-old rat hippocampus in vitro

1991 • 61 citations

Diminished calcium currents in aged hippocampal dentate gyrus granule neurones

1989 • 57 citations

Functional elongation of CA1 hippocampal neurons with aging in Fischer 344 rats

1991 • 54 citations

Reversed ethanol effects on potassium conductances in aged hippocampal dentate granule neurons

1988 • 43 citations

Muscle-specific decrease in presynaptic calcium dependence and clearance during neuromuscular transmission in aged rats

1988 • 42 citations

Acetylcholine, aging and anatomy: differential effects in the hippocampus

1986 • 42 citations

Intracellular neurophysiological analysis reveals alterations in excitation in striatal neurons in aged rats

1989 • 34 citations

Age-related deterioration of long-term potentiation in the CA3 and CA1 regions of hippocampal slices from the senescence-accelerated mouse

1990 • 26 citations

Differential effects of age on subpopulations of hippocampal theta cells

1992 • 20 citations

Effects of age on l-Glutamate-induced depolarization in three hippocampal subfields

1993 • 12 citations

Behavioral state dependence of homo- and hetero-synaptic modulation of dentate gyrus excitability

1993 • 10 citations