NMDA receptor antagonists can enhance or impair learning performance in animals

Exploratory Data Analysis

1977 • 12,265 citations

Developments of a water-maze procedure for studying spatial learning in the rat

1984 • 6,896 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

Hippocampus, space, and memory

1979 • 2,033 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain

1985 • 1,294 citations

NMDA receptors - their role in long-term potentiation

1987 • 1,177 citations

Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors

1984 • 905 citations

Long-Term Potentiation

1987 • 804 citations

Excitatory amino acids in the brain - focus on NMDA receptors

1987 • 641 citations

Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters

1985 • 558 citations

Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 496 citations

The effects of hippocampal lesions upon spatial and non-spatial tests of working memory

1986 • 489 citations

THE EFFECTS OF A SERIES OF ω‐PHOSPHONIC α‐CARBOXYLIC AMINO ACIDS ON ELECTRICALLY EVOKED AND EXCITANT AMINO ACID‐INDUCED RESPONSES IN ISOLATED SPINAL CORD PREPARATIONS

1982 • 463 citations

Spatial learning and memory processes: the search for their neurobiological mechanisms in the rat

1988 • 426 citations

Mediation of thalamic sensory input by both NMDA receptors and non-NMDA receptors

1986 • 305 citations

MK-801 blocks NMDA receptor-mediated synaptic transmission and long term potentiation in rat hippocampal slices

1987 • 194 citations

The behavioural effects of an N-methylaspartate receptor antagonist following application to the lumbar spinal cord of conscious rats

1984 • 172 citations

The role of N‐methylaspartate receptors in mediating responses of rat and cat spinal neurones to defined sensory stimuli.

1987 • 104 citations

Muscle relaxant action of excitatory amino acid antagonists

1985 • 100 citations

Mode of action of excitatory amino acid receptor antagonists on hippocampal long-lasting potentiation

1986 • 74 citations

A role for receptors of N-methyl-D-aspartic acid in the discriminative stimulus properties of phencyclidine

1987 • 71 citations

Phencyclidine-like behavioral effects in pigeons induced by systemic administration of the excitatory amino acid antagonist, 2-amino-5-phosphonovalerate

1986 • 54 citations

The N-methyl-D-aspartate antagonist, 2-amino-7-phosphonoheptanoate, produces phencyclidine-like behavioral effects in rats

1987 • 40 citations

Uptake of a novel anticonvulsant compound, 2-amino-7-phosphono-[4,5-3H]Heptanoic acid, into mouse brain

1983 • 35 citations

2-amino-7-phosphonoheptanoic acid depresses γ-motoneurons and polysynaptic reflexes in the cat spinal cord

1985 • 34 citations

Pharmacological modulation of memory: trends and problems

2009 • 17 citations

Determination of the pharmacokinetics of 2-amino-7-phosphonoheptanoate in rat plasma and cerebrospinal fluid

1988 • 11 citations