Increase in Single L-Type Calcium Channels in Hippocampal Neurons During Aging

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Three types of neuronal calcium channel with different calcium agonist sensitivity

1985 • 2,212 citations

Ionic dependence of glutamate neurotoxicity

1987 • 1,811 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

Multiple types of neuronal calcium channels and their selective modulation

1988 • 1,399 citations

Active propagation of somatic action potentials into neocortical pyramidal cell dendrites

1994 • 1,303 citations

Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists

1984 • 1,292 citations

A thin slice preparation for patch clamp recordings from neurones of the mammalian central nervous system

1989 • 1,283 citations

Calcium Fluxes, Calcium Antagonists, and Calcium-Related Pathology in Brain Ischemia, Hypoglycemia, and Spreading Depression: A Unifying Hypothesis

1989 • 1,237 citations

Fitting and Statistical Analysis of Single-Channel Records

1983 • 1,098 citations

Classes of Calcium Channels in Vertebrate Cells

1989 • 1,082 citations

Pharmacological dissection of multiple types of Ca2+ channel currents in rat cerebellar granule neurons

1995 • 819 citations

P-type calcium channels in rat central and peripheral neurons

1992 • 788 citations

Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison.

1989 • 631 citations

Prolonged Ca ²⁺ -Dependent Afterhyperpolarizations in Hippocampal Neurons of Aged Rats

1984 • 489 citations

Synaptic Activation of Voltage-Gated Channels in the Dendrites of Hippocampal Pyramidal Neurons

1995 • 449 citations

Isolation of neurons suitable for patch-clamping from adult mammalian central nervous systems

1986 • 416 citations

Voltage-activated calcium channels that must be phosphorylated to respond to membrane depolarization.

1987 • 393 citations

Calcium and the aging nervous system

1987 • 384 citations

Perforated patch-clamp analysis of the passive membrane properties of three classes of hippocampal neurons

1992 • 375 citations

Advances in Alzheimer's disease

1991 • 358 citations

Calcium channels in muscle cells isolated from rat mesenteric arteries: modulation by dihydropyridine drugs.

1986 • 347 citations

Age-related spatial reference and working memory deficits assessed in the water maze

1995 • 314 citations

Nimodipine Facilitates Associative Learning in Aging Rabbits

1989 • 305 citations

Nimodipine increases excitability of rabbit CA1 pyramidal neurons in an age- and concentration-dependent manner

1992 • 293 citations

Developmental changes in Na+ conductances in rat neocortical neurons: appearance of a slowly inactivating component

1988 • 289 citations

Corticosteroid Modulation of Hippocampal Potentials: Increased Effect with Aging

1989 • 274 citations

Dihydropyridine receptors in muscle are voltage-dependent but most are not functional calcium channels

1985 • 264 citations

Voltage-dependent potentiation of L-type Ca2+ channels due to phosphorylation by cAMP-dependent protein kinase

1993 • 264 citations

Pharmacological basis for the use of nimodipine in central nervous system disorders

1989 • 248 citations

Geometric Parameters of Pipettes and Membrane Patches

1983 • 238 citations

Voltage-dependent modulation of Ca channel current in heart cells by Bay K8644.

1986 • 199 citations

Properties and distribution of single voltage-gated calcium channels in adult hippocampal neurons

1990 • 178 citations

Science and Technology of Patch-Recording Electrodes

1983 • 162 citations

Inhibition of calcium channels in rat CA3 pyramidal neurons by a metabotropic glutamate receptor

1992 • 162 citations

Evidence for multiple types of Ca2+ channels in acutely isolated hippocampal CA3 neurones of the guinea‐pig.

1991 • 143 citations

Aging-related prolongation of calcium spike duration in rat hippocampal slice neurons

1990 • 128 citations

Voltage-dependent phosphorylation may recruit Ca2+ current facilitation in chromaff in cells

1992 • 126 citations

Estimating the number of channels in patch recordings

1991 • 124 citations

Mechanisms of neuronal death in brain aging and alzheimer's disease: Role of endocrine‐mediated calcium dyshomeostasis

1992 • 118 citations

An age-related spatial learning deficit: Choline uptake distinguishes “impaired” and “unimpaired” rats

1988 • 108 citations

Calcium binding to the cytosol and calcium extrusion mechanisms in intact synaptosomes and their alterations with aging.

1992 • 102 citations

Functional diversity of L-type calcium channels in rat cerebellar neurons

1993 • 99 citations

Nimodipine decreases calcium action potentials in rabbit hippocampal CA1 neurons in an age‐dependent and concentration‐dependent manner

1994 • 97 citations

Calcium currents in aged rat dorsal root ganglion neurones.

1993 • 87 citations

Excitatory transmitter neurotoxicity

1994 • 82 citations

Confocal laser scanning microscopy reveals voltage‐gated calcium signals within hippocampal dendritic spines

1994 • 76 citations

Functional Aspects of Calcium-Channel Modulation

1993 • 72 citations

Regulation of calcium levels in brain tissue from adult and aged rats

1992 • 67 citations

Age-related reduced affinity in [3H]nitrendipine labeling of brain voltage-dependent calcium channels

1985 • 65 citations

Multiple components of calcium current in acutely dissociated dentate gyrus granule neurons

1994 • 61 citations

Measurements of intracellular calcium in sensory neurons of adult and old rats

1992 • 61 citations

Aging-Related Increases in Voltage-Sensitive, Inactivating Calcium Currents in Rat Hippocampus Implications for Mechanisms of Brain Aging and Alzheimer's Disease

1989 • 57 citations

Diminished calcium currents in aged hippocampal dentate gyrus granule neurones

1989 • 57 citations

The molecular mode of action of the Ca agonist (?) BAY K 8644 on the cardiac Ca channel

1993 • 51 citations

Enhanced acquisition of reversal training in a spatial learning task in rats treated with chronic nimodipine

1993 • 50 citations

Reopening of Ca2+ channels in mouse cerebellar neurons at resting membrane potentials during Recovery from Inactivation

1991 • 49 citations

Selective potentiation of a novel calcium channel in rat hippocampal neurones.

1994 • 49 citations

Enzymatic Gating of Voltage‐Activated Calcium Channels

1991 • 46 citations

Norepinephrine and isoproterenol increase the phosphorylation of synapsin I and synapsin II in dentate slices of young but not aged Fisher 344 rats.

1991 • 42 citations

Muscle-specific decrease in presynaptic calcium dependence and clearance during neuromuscular transmission in aged rats

1988 • 42 citations

Whole-cell voltage-clamp recordings in granule cells acutely isolated from hippocampal slices of adult or aged rats

1989 • 42 citations

Low Ba2+ and Ca2+ induce a sustained high probability of repolarization openings of L-type Ca2+ channels in hippocampal neurons: physiological implications.

1993 • 37 citations

Molecular Properties of Calcium Channels in Skeletal Muscle and Neurons

1993 • 34 citations

[52] Analysis of nonstationary single-channel currents

1992 • 29 citations

Aging enhances the calcium sensitivity of central neurons of the mouse as an adaptive response to reduced free intracellular calcium

1993 • 24 citations

Single-channel and whole-cell studies of calcium currents in young and aged rat hippocampal slice neurons

1995 • 17 citations

Calcium Imaging in Hippocampal Neurons using Confocal Microscopy^a

1994 • 16 citations

Changes in neuronal function downstream from the receptor in the aging brain: protein kinases and phosphoproteins

1992 • 12 citations