LTP, NMDA, genes and learning

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1994 • 3,437 citations

The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory

1996 • 1,750 citations

Control of Memory Formation Through Regulated Expression of a CaMKII Transgene

1996 • 1,525 citations

Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,336 citations

Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain

1996 • 1,272 citations

Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice

1992 • 1,138 citations

Organization of Behavior.

1950 • 1,082 citations

Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?

1996 • 895 citations

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit

1995 • 832 citations

Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala

1990 • 806 citations

Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D- aspartate receptor antagonist AP5

1989 • 766 citations

Impaired Hippocampal Representation of Space in CA1-Specific NMDAR1 Knockout Mice

1996 • 594 citations

Distinct components of spatial learning revealed by prior training and NMDA receptor blockade

1995 • 560 citations

CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP

1995 • 530 citations

Hippocampal EEG and behavior: Change in amplitude and frequency of RSA (Theta rhythm) associated with spontaneous and learned movement patterns in rats and cats

1973 • 509 citations

Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal ltp in the range of the θ frequency

1995 • 464 citations

Cerebral Activity and Behavior: Control by Central Cholinergic and Serotonergic Systems

1988 • 462 citations

An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?

1985 • 457 citations

Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism

1986 • 416 citations

Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors.

1992 • 412 citations

The Amygdala and Fear Conditioning: Has the Nut Been Cracked?

1996 • 405 citations

Initial events of myelination involve Fyn tyrosine kinase signalling

1994 • 383 citations

Excitatory amino acids and synaptic transmission: the evidence for a physiological function

1990 • 370 citations

Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus

1991 • 370 citations

The NMDA Receptor

1995 • 356 citations

Rats with fimbria-fornix lesions display a place response in a swimming pool: a dissociation between getting there and knowing where

1995 • 334 citations

Spatial learning without NMDA receptor-dependent long-term potentiation

1995 • 326 citations

The Role of NMDA Receptors in Information Processing

1993 • 313 citations

The location and function of NMDA receptors in cat and kitten visual cortex

1989 • 310 citations

Long-term potentiation: What's learning got to do with it?

1997 • 308 citations

LTP is accompanied by commensurate enhancement of auditory-evoked responses in a fear conditioning circuit

1995 • 293 citations

A genetic test of the effects of mutations in PKA on mossy fiber ltp and its relation to spatial and contextual learning

1995 • 275 citations

Mice Expressing Activated CaMKII Lack Low Frequency LTP and Do Not Form Stable Place Cells in the CA1 Region of the Hippocampus

1996 • 234 citations

Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1

1996 • 230 citations

Effects of the NMDA receptor/channel antagonists CPP and MK801 on hippocampal field potentials and long-term potentiation in anesthetized rats

1988 • 198 citations

The excitatory amino acid antagonist d-CPP-ene (SDZ EAA-494) in patients with epilepsy

1993 • 194 citations

Patch clamp analysis of excitatory synaptic currents in granule cells of rat hippocampus.

1991 • 159 citations

Detailed behavioral analysis of water maze acquisition under systemic NMDA or muscarinic antagonism: Nonspatial pretraining eliminates spatial learning deficits.

1996 • 156 citations

Involvement of LTP in memory: Are we “searching under the street light”?

1995 • 150 citations

Modification of the Effects of an Amphetamine–Barbiturate Mixture by the Past Experience of Rats

1961 • 150 citations

Detailed behavioral analysis of water maze acquisition under APV or CNQX: Contribution of sensorimotor disturbances to drug-induced acquisition deficits.

1996 • 150 citations

Enhancement of spatial learning in F344 rats by physical activity and related learning-associated alterations in hippocampal and cortical cholinergic functioning

1991 • 143 citations

Dissociating performance and learning deficits on spatial navigation tasks in rats subjected to cholinergic muscarinic blockade

1989 • 140 citations

Dependence of retinogeniculate transmission in cat on NMDA receptors

1990 • 135 citations

Metabotropic glutamate receptors in hippocampal long‐term potentiation and learning and memory

1996 • 132 citations

Dopaminergic regulation of striatal acetylcholine release: importance of D1 and N-methyl-D-aspartate receptors.

1991 • 123 citations

Detailed behavioral analysis of water maze acquisition under APV or CNQX: Contribution of sensorimotor disturbances to drug-induced acquisition deficits.

1996 • 123 citations

An alternative to the LTP orthodoxy: a plasticity-pathology continuum model

1996 • 103 citations

Hyperactivity, hyper-reactivity, and sensorimotor deficits induced by low doses of the N-methyl-d-aspartate non-competitive channel blocker MK801

1992 • 103 citations

Steel mutant mice are deficient in hippocampal learning but not long-term potentiation.

1996 • 99 citations

Newly Learned Auditory Responses Mediated by NMDA Receptors in the Owl Inferior Colliculus

1996 • 82 citations

A reevaluation of excitatory amino acid-mediated synaptic transmission in rat dentate gyrus

1990 • 80 citations

The Neuroscience of Spatial Navigation: Focus on Behavior Yields Advances

1996 • 74 citations

Testing hypotheses of spatial learning: the role of NMDA receptors and NMDA-mediated long-term potentiation

1997 • 73 citations

The role of NMDA receptors in learning and memory

1995 • 68 citations

Effects of the NMDA antagonists CPP and MK-801 on delayed conditional discrimination

1989 • 67 citations

Prior non-spatial pretraining eliminates sensorimotor disturbances and impairments in water maze learning caused by diazepam

1997 • 64 citations

Age and Stress History Effects on Spatial Performance in a Swim Task in Fischer-344 Rats

1996 • 58 citations

N-methyl-d-aspartate receptors modulate extracellular dopamine concentration and metabolism in rat hippocampus and striatum in vivo

1994 • 54 citations

Both competitive and non-competitive antagonists of N-methyl-D-aspartic acid disrupt brightness discrimination in rats

1988 • 52 citations

Importance of NMDA receptors for multimodal integration in the deep layers of the cat superior colliculus

1996 • 51 citations

The NMDA antagonist MK-801 can impair attention to exteroceptive stimuli

1994 • 51 citations

Specialized Subsystems for Processing Biologically Important Complex Sounds: Cross-correlation Analysis for Ranging in the Bat's Brain

1990 • 48 citations

Amino acid receptor mediated excitatory synaptic transmission in the cat red nucleus.

1986 • 47 citations

Differential regulation, by MK-801, of dopamine receptor gene expression in rat nigrostriatal and mesocorticolimbic systems

1996 • 45 citations

Report on the Geology of the North-West of Sutherland

1884 • 43 citations

Preservation of spatial learning in fyn tyrosine kinase knockout mice

1996 • 41 citations

The effect of dizocilpine (MK-801) on spatial and visual discrimination tasks in the rat

1995 • 35 citations

Initial events of myelination involve Fyn tyrosine kinase signaling

1995 • 27 citations

Intrahippocampal administration of both the d- and the l-isomers of AP5 disrupt spontaneous alternation behavior and evoked potentials

1994 • 26 citations

A Model for the Action of NMDA Conductances in the Visual Cortex

1992 • 26 citations

Previous experience disrupts atropine-induced stereotyped "trapping" in rats.

1985 • 20 citations

Systemic NMDA antagonist CGP-37849 produces non-specific impairment in a working memory task: The effect does not resemble those of AP5 and of lesions of the hippocampus or fornix

1996 • 15 citations

Systemic NMDA Receptor Antagonist CGP-40116 Does Not Impair Memory Acquisition but Protects against NMDA Neurotoxicity in Rhesus Monkeys

1996 • 15 citations

Previous experience disrupts atropine-induced stereotyped "trapping" in rats.

1985 • 13 citations

The role of NMDA receptors in synaptic integration and the organization of motor patterns

1995 • 6 citations

NMDA receptors and their interactions with other excitatory amino acid receptors in synaptic transmission in the mammalian central nervous system

1995 • 5 citations

The importance of NMDA receptors in the processing of spinal primary afferent input

1995 • 4 citations