A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.

Neural networks and physical systems with emergent collective computational abilities.

1982 • 18,281 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

The Organization of Behavior: A Neuropsychological Theory

1950 • 4,130 citations

Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex

1982 • 2,824 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

Computing with Neural Circuits: A Model

1986 • 2,076 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices.

1980 • 1,759 citations

Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP

1989 • 1,335 citations

Intracellular injections of EGTA block induction of hippocampal long-term potentiation

1983 • 1,106 citations

Regulation of brain Type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: A Ca2+-triggered molecular switch

1986 • 856 citations

Postsynaptic Calcium Is Sufficient for Potentiation of Hippocampal Synaptic Transmission

1988 • 830 citations

A Critical Period for Macromolecular Synthesis in Long-Term Heterosynaptic Facilitation in Aplysia

1986 • 767 citations

A Physiological Mechanism for Hebb's Postulate of Learning

1973 • 711 citations

Glutamate activates multiple single channel conductances in hippocampal neurons

1987 • 691 citations

Protein Phosphatases: Properties and Role in Cellular Regulation

1983 • 645 citations

Biochemical and immunochemical evidence that the "major postsynaptic density protein" is a subunit of a calmodulin-dependent protein kinase.

1983 • 617 citations

Loss of calcium/calmodulin responsiveness in adenylate cyclase of rutabaga, a Drosophila learning mutant

1984 • 589 citations

Calcium regulation of the neuronal growth cone

1988 • 581 citations

Synapses as associative memory elements in the hippocampal formation

1979 • 573 citations

Hebbian synapses in hippocampus.

1986 • 560 citations

Persistent protein kinase activity underlying long-term potentiation

1988 • 557 citations

Identification of a calcium-binding protein as a calcium-dependent regulator of brain adenylate cyclase.

1975 • 546 citations

Contributions of Quisqualate and NMDA Receptors to the Induction and Expression of LTP

1988 • 512 citations

Associative long-term depression in the hippocampus induced by hebbian covariance

1989 • 470 citations

Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogaster

1981 • 444 citations

Protein phosphorylation in the brain

1983 • 428 citations

The action of N‐methyl‐D‐aspartic acid on mouse spinal neurones in culture.

1985 • 417 citations

Development of neuronal polarity: GAP-43 distinguishes axonal from dendritic growth cones

1988 • 413 citations

Evidence that the major postsynaptic density protein is a component of a Ca2+/calmodulin-dependent protein kinase.

1984 • 389 citations

Regulation of calmodulin binding to P-57. A neurospecific calmodulin binding protein.

1987 • 334 citations

Noradrenergic enhancement of long-term potentiation at mossy fiber synapses in the hippocampus

1988 • 314 citations

DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Regional and cellular distribution in the rat brain

1984 • 303 citations

Neural plasticity without postsynaptic action potentials: less-active inputs become dominant when kitten visual cortical cells are pharmacologically inhibited.

1988 • 272 citations

Feasibility of long-term storage of graded information by the Ca2+/calmodulin-dependent protein kinase molecules of the postsynaptic density.

1988 • 261 citations

Phosphorylation-dependent subcellular translocation of a Ca2+/calmodulin-dependent protein kinase produces an autonomous enzyme in Aplysia neurons.

1985 • 261 citations

Mapping calcium transients in the dendrites of Purkinje cells from the guinea‐pig cerebellum in vitro.

1987 • 225 citations

The Dynamics of Free Calcium in Dendritic Spines in Response to Repetitive Synaptic Input

1987 • 205 citations

The postsynaptic density: a possible role in long-lasting effects in the central nervous system.

1985 • 194 citations

Plasticity in the organization of adult cerebral cortical maps: a computer simulation based on neuronal group selection

1987 • 191 citations

Identification of protein phosphatase 1 in synaptic junctions: dephosphorylation of endogenous calmodulin-dependent kinase II and synapse-enriched phosphoproteins

1985 • 162 citations

Inhibitors of calmodulin and protein kinase C block different phases of hippocampal long-term potentiation

1988 • 153 citations

Calcium binding to complexes of calmodulin and calmodulin binding proteins

1985 • 152 citations

Localization in mammalian brain of G-substrate, a specific substrate for guanosine 3',5'-cyclic monophosphate-dependent protein kinase

1984 • 116 citations

Synaptic Modification, Neuron Selectivity, and Nervous System Organization

2014 • 114 citations

Ca2+-dependent regulation of guinea pig brain adenylate cyclase.

1980 • 114 citations

Long-term potentiation: From biophysics to behavior

1989 • 103 citations

DARPP‐32 and Phosphatase Inhibitor‐1, Two Structurally Related Inhibitors of Protein Phosphatase‐1, Are Both Present in Striatonigral Neurons

1988 • 49 citations

Activation of protein kinase isoenzymes under near physiological conditions

1982 • 45 citations

Evaluation of a model of long-term memory based on the properties of the Ca2+/calmodulin-dependent protein kinase.

1988 • 38 citations

A comparative immunohistochemical study of calcineurin and S-100 protein in mammalian and avian brains

1988 • 25 citations

Distinct interactions between Ca2+/calmodulin and neurotransmitter stimulation of adenylate cyclase in striatum and hippocampus

1988 • 25 citations

Calmodulin·(Ca2+)4 is the active calmodulin-calcium species activating the calcium-, calmodulin-dependent protein kinase of cardiac sarcoplasmic reticulum in the regulation of the calcium pump

1984 • 22 citations