Free radicals, antioxidants, and human disease: where are we now?

Free radicals in biology and medicine

1991 • 17,840 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Beyond Cholesterol

1989 • 6,533 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

Oxidative stress: oxidants and antioxidants

1997 • 4,454 citations

ACUTE RESPIRATORY DISTRESS IN ADULTS

1967 • 4,096 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

1981 • 2,777 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

The deoxyribose method: A simple “test-tube” assay for determination of rate constants for reactions of hydroxyl radicals

1987 • 2,350 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

DNA Damage and Oxygen Radical Toxicity

1988 • 1,964 citations

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

1990 • 1,896 citations

Ascorbate is an outstanding antioxidant in human blood plasma.

1989 • 1,876 citations

Continuous Monitoring ofin VztroOxidation of Human Low Density Lipoprotein

1989 • 1,824 citations

The chemical basis of radiation biology

1987 • 1,788 citations

DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems

1991 • 1,555 citations

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1989 • 1,367 citations

The antioxidants of human extracellular fluids

1990 • 1,352 citations

The measurement and mechanism of lipid peroxidation in biological systems

1990 • 1,273 citations

Mechanisms of carbon tetrachloride toxicity

1989 • 1,250 citations

Oxidants and human disease: some new concepts ¹

1987 • 1,171 citations

Role of metals in oxygen radical reactions

1985 • 1,149 citations

Metal ion-catalyzed oxidation of proteins: Biochemical mechanism and biological consequences

1990 • 1,143 citations

Increased Nigral Iron Content and Alterations in Other Metal Ions Occurring in Brain in Parkinson's Disease

1989 • 1,117 citations

Free Radicals and Inflammation: Protection of Synovial Fluid by Superoxide Dismutase

1974 • 1,109 citations

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

1990 • 1,100 citations

A compilation of specific bimolecular rate constants for the reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals with inorganic and organic compounds in aqueous solution

1967 • 981 citations

Superoxide dismutases

1989 • 953 citations

How to Characterize a Biological Antioxidant

1990 • 943 citations

Metal-catalyzed oxidation of proteins. Physiological consequences

1991 • 877 citations

Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex

1978 • 876 citations

Role of Ca2+ in toxic cell killing

1989 • 856 citations

Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo.

1990 • 827 citations

Oxygen radicals and the nervous system

1985 • 822 citations

LIPID PEROXIDATION, OXYGEN RADICALS, CELL DAMAGE, AND ANTIOXIDANT THERAPY

1984 • 820 citations

Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene

1991 • 788 citations

Superoxide‐dependent formation of hydroxyl radicals in the presence of iron chelates

1978 • 748 citations

The role of 8-hydroxyguanine in carcinogenesis

1990 • 732 citations

The oxidative inactivation of mitochondrial electron transport chain components and ATPase.

1990 • 718 citations

Endogenous Oxidative DNA Damage, Aging, and Cancer

1989 • 711 citations

Iron transport and storage

1987 • 688 citations

A Mechanism for the Production of Ethylene from Methional

1970 • 668 citations

The antioxidant role of vitamin C

1986 • 660 citations

State of the Art

1983 • 655 citations

Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine

1979 • 637 citations

Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides

1986 • 634 citations

Modulation of fibroblast proliferation by oxygen free radicals

1990 • 617 citations

Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide.

1988 • 614 citations

Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives

1991 • 604 citations

LONG-TERM OUTCOME OF TREATING RHEUMATOID ARTHRITIS: RESULTS AFTER 20 YEARS

1987 • 593 citations

Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial "stunning" is a manifestation of reperfusion injury.

1989 • 580 citations

Central nervous system trauma and strokeII. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation

1989 • 580 citations

Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin

1989 • 569 citations

Manganese superoxide dismutase can reduce cellular damage mediated by oxygen radicals in transgenic plants.

1991 • 558 citations

Interleukin-8 (IL-8): The Major Neutrophil Chemotactic Factor in the Lung

1991 • 550 citations

Selective Increase of Iron in Substantia Nigra Zona Compacta of Parkinsonian Brains

1991 • 516 citations

Superoxide sensitivity of the Escherichia coli aconitase.

1991 • 499 citations

Copper-ion-dependent damage to the bases in DNA in the presence of hydrogen peroxide

1991 • 487 citations

Vitamin C and cancer prevention: the epidemiologic evidence

1991 • 470 citations

Vitamin E as an in Vitro and in Vivo Antioxidant^a

1989 • 447 citations

Formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Is haemoglobin a biological Fenton reagent?

1988 • 408 citations

Assay of metabolic superoxide production in Escherichia coli.

1991 • 405 citations

Non-transferrin-bound iron in plasma or serum from patients with idiopathic hemochromatosis

1989 • 401 citations

Pharmacologic approach to tissue injury mediated by free radicals and other reactive oxygen metabolites

1991 • 394 citations

Initiation of lipid peroxidation in biological systems

1987 • 385 citations

Drug Antioxidant Effects

1991 • 365 citations

Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling

1990 • 358 citations

Free Radicals in Medicine. II. Involvement in Human Disease

1988 • 344 citations

On the participation of higher oxidation states of iron and copper in fenton reactions

1989 • 333 citations

Damage to the Bases in DNA Induced by Hydrogen Peroxide and Ferric Ion Chelates

1989 • 332 citations

OXIDANT ACTIVITY IN EXPIRED BREATH OF PATIENTS WITH ADULT RESPIRATORY DISTRESS SYNDROME

1986 • 330 citations

Reactivity of hydroxyl and hydroxyl-like radicals discriminated by release of thiobarbituric acid-reactive material from deoxy sugars, nucleosides and benzoate

1984 • 313 citations

Free radicals and myocardial ischemia and reperfusion injury.

1987 • 307 citations

Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species.

1991 • 305 citations

VITAMIN E AND NEUROLOGICAL FUNCTION

1983 • 287 citations

The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation

1987 • 286 citations

The Role of Reperfusion-Induced Injury in the Pathogenesis of the Crush Syndrome

1991 • 284 citations

Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation

1988 • 280 citations

Modification of plasma proteins by cigarette smoke as measured by protein carbonyl formation

1992 • 279 citations

Will antioxidant nutrients slow aging processes?

1968 • 279 citations

Low-molecular-weight iron complexes and oxygen radical reactions in idiopathic haemochromatosis

1985 • 277 citations

OCULAR TOXICITY OF HIGH-DOSE INTRAVENOUS DESFERRIOXAMINE

1983 • 269 citations

Oxidants, inflammation, and anti‐inflammatory drugs

1988 • 267 citations

A Global View of Human Selenium Nutrition

1987 • 264 citations

SOME PROPERTIES OF THE ASCORBATE FREE RADICAL^*

1975 • 262 citations

Hemoglobin potentiates central nervous system damage.

1987 • 262 citations

Methods for the Measurement of Hydroxyl Radicals in Biochemical Systems: Deoxyribose Degradation and Aromatic Hydroxylation

1988 • 261 citations

Free Radicals and Their Involvement During Long-Term Myocardial Ischemia and Reperfusion

1990 • 259 citations

Inhibition of lipid peroxidation by the iron-binding protein lactoferrin

1981 • 258 citations

Action of biologically-relevant oxidizing species upon uric acid. Identification of uric acid oxidation products

1990 • 245 citations

Copper salt-dependent hydroxyl radical formation

1983 • 242 citations

Unusual copper-induced sensitization of the biological damage due to superoxide radicals.

1981 • 240 citations

Measurement of allantoin and uric acid in human body fluids. A potential index of free-radical reactions in vivo?

1987 • 240 citations

Superoxide dismutase-rich bacteria. Paradoxical increase in oxidant toxicity.

1987 • 238 citations

Increased Hydrogen Peroxide in the Expired Breath of Patients with Acute Hypoxemic Respiratory Failure

1989 • 225 citations

Lipid peroxidation in rheumatoid arthritis: Thiobarbituric acid-reactive material and catalytic iron salts in synovial fluid from rheumatoid patients

1984 • 224 citations

Inhibition of coronary artery superoxide dismutase attenuates endothelium-dependent and -independent nitrovasodilator relaxation.

1991 • 215 citations

Site-specific modification of albumin by free radicals. Reaction with copper(II) and ascorbate

1986 • 212 citations

Rapid inactivation of plant aconitase by hydrogen peroxide

1991 • 202 citations

Evidence for superoxide-dependent reduction of Fe3+ and its role in enzyme-generated hydroxyl radical formation

1976 • 201 citations

Ascorbic Acid Transport and Accumulation in Human Neutrophils

1989 • 192 citations

The Inhibition of Lipid Autoxidation by Human Serum and its Relation to Serum Proteins and α-Tocopherol

1974 • 188 citations

Cerebral and Ocular Toxicity Induced by Desferrioxamine

1985 • 179 citations

Oxidative damage to hyaluronate and glucose in synovial fluid during exercise of the inflamed rheumatoid joint. Detection of abnormal low-molecular-mass metabolites by proton-n.m.r. spectroscopy

1991 • 178 citations

Hydrogen Peroxide is Involved in Hamster Sperm Capacitation in Vitro1

1991 • 178 citations

Mechanisms of oxidant injury of cells

1991 • 177 citations

Self-perpetuating mechanisms of immunoglobulin G aggregation in rheumatoid inflammation.

1985 • 175 citations

Glutathione depleting agents and lipid peroxidation

1987 • 174 citations

Aspects to Consider When Detecting and Measuring Lipid Peroxidation

1986 • 172 citations

Cytotoxicity from Coupled Redox Cycling of Autoxidizing Xenobiotics and Metals: A Selective Critical Review and Commentary on Work‐in‐Progress

1984 • 170 citations

Evidence that desferrioxamine cannot enter cells by passive diffusion

1991 • 164 citations

Therapeutic potential of vitamin E in the pathogenesis of spontaneous atherosclerosis

1991 • 164 citations

The Determination of Dehydroascorbic Acid and Ascorbic acid in the Serum and Synovial Fluid of Patients with Rheumatoid Arthritis (RA)

1985 • 154 citations

The iron-binding and hydroxyl radical scavenging action of anti-inflammatory drugs

1988 • 154 citations

Role of tocopherols in the protection of biological systems against oxidative damage

1991 • 151 citations

The Control of Oxidant Stress at Fertilization

1991 • 149 citations

Oxygen radicals: mediators of gastrointestinal pathophysiology.

1989 • 146 citations

THE IMPORTANCE OF IRON IN RHEUMATOID DISEASE

1981 • 145 citations

Molecular biology of selenium with implications for its metabolism ¹

1991 • 143 citations

Activation of Human Immunodeficiency Virus Type 1 by Oxidative Stress

1990 • 142 citations

Transgenic mice with expression of elevated levels of copper-zinc superoxide dismutase in the lungs are resistant to pulmonary oxygen toxicity.

1991 • 141 citations

In Vivo Generation of Hydrogen Peroxide in the Rat Corpus Luteum during Luteolysis*

1991 • 138 citations

Immunoaffinity isolation of urinary 8-hydroxy-2′-deoxygunosine and 8-hydroxyguanine and quantitation of 8-hydroxy-2′deoxyguanosine in DNA by polyclonal antibodies

1991 • 135 citations

[15] Sulfur-centered free radicals

1990 • 134 citations

Hydroxylation of salicylate by microsomal fractions and cytochrome P-450. Lack of production of 2,3-dihydroxybenzoate unless hydroxyl radical formation is permitted

1991 • 133 citations

Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane

1991 • 130 citations

2 The development of iron chelating drugs

1989 • 129 citations

Invited Commentary:Superoxide, Iron, Vascular Endothelium and Reperfusion Injury

1989 • 128 citations

Nickel(II)- and cobalt(II)-dependent damage by hydrogen peroxide to the DNA bases in isolated human chromatin.

1991 • 126 citations

Neurochemical, neurophysiological, and neuropathological studies in vitamin E deficiency.

1990 • 124 citations

Chemical nature of in vivo DNA base damage in hydrogen peroxide-treated mammalian cells

1991 • 122 citations

Oxidative stress and abnormal cholesterol metabolism in patients with adult respiratory distress syndrome.

1990 • 121 citations

Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs.

1991 • 120 citations

Superoxide dismutase inhibits the superoxide-driven Fenton reaction at two different levels

1985 • 118 citations

Phospholipid hydroperoxide glutathione peroxidase is the 18-kDa selenoprotein expressed in human tumor cell lines.

1991 • 118 citations

Cellular Iron Metabolism in Health and Diseased

1990 • 117 citations

Expression of Bovine Superoxide Dismutase in Drosophila melanogaster Augments Resistance to Oxidative Stress

1991 • 117 citations

Antioxidant activity of probucol and its analogs in hypercholesterolemic Watanabe rabbits

1991 • 116 citations

Superoxide dismutase for therapeutic use: Clinical experience, dead ends and hopes

1988 • 115 citations

Copper-phenanthroline-induced site-specific oxygen-radical damage to DNA. Detection of loosely bound trace copper in biological fluids

1984 • 114 citations

On the limited ability of superoxide to release iron from ferritin

1990 • 114 citations

Detection of Myoglobin-Derived Radicals On Reaction of Metmyoglobin With Hydrogen Peroxide and Other Peroxidic Compounds

1990 • 113 citations

The Generation of Ferryl or Hydroxyl Radicals During Interaction of Haemproteins with Hydrogen Peroxide

1988 • 109 citations

A Critical Evaluation of New Agents for the Treatment of Sepsis

1991 • 109 citations

Stimulated human neutrophils limit iron-catalyzed hydroxyl radical formation as detected by spin-trapping techniques.

1986 • 108 citations

LIPID PEROXIDATION AND THE CYTOTOXICITY OF COPPER*

1980 • 107 citations

Concentration-dependent antioxidant activity of probucol in low density lipoproteins in vitro: probucol degradation precedes lipoprotein oxidation.

1989 • 107 citations

Breath Pentane Excretion as a Marker of Disease Activity in Rheumatoid Arthritis

1988 • 103 citations

Brain iron : neurochemical and behavioural aspects

1988 • 103 citations

Superoxide dismutase and Fenton chemistry. Reaction of ferric-EDTA complex and ferric-bipyridyl complex with hydrogen peroxide without the apparent formation of iron(II)

1990 • 103 citations

Increases in cytosolic calcium ion concentration can be dissociated from the killing of cultured hepatocytes by tert-butyl hydroperoxide.

1991 • 102 citations

Formation of Hydroxyl Radicals in Biological Systems. Does Myoglobin Stimulate Hydroxyl Radical Formation from Hydrogen Peroxide?

1988 • 102 citations

Oxidative damage to plasma constituents by ozone

1992 • 102 citations

Neutrophils isolated from the synovial fluid of patients with rheumatoid arthritis: priming and activation in vivo.

1991 • 99 citations

Endocytosis of superoxide dismutase is required in order for the enzyme to protect hepatocytes from the cytotoxicity of hydrogen peroxide.

1988 • 98 citations

The presence of neutrophil elastase and evidence of oxidation activity in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome.

1983 • 97 citations

Free radicals mediate actions of oxyhemoglobin on cerebrovascular smooth muscle cells.

1991 • 97 citations

Quantification of noncyclooxygenase derived prostanoids as a marker of oxidative stress

1991 • 97 citations

Enhancement of erythrocyte superoxide dismutase activity: effects on cellular oxidant defense

1989 • 95 citations

Occurrence of the adult respiratory distress syndrome in neutropenic patients.

1986 • 94 citations

Bleomycin‐detectable iron in serum from leukaemic patients before and after chemotherapy Therapeutic implications for treatment with oxidant‐generating drugs

1988 • 94 citations

The Suppression of Iron Release from Activated Myoglobin by Physiological Electron Donors and by Desferrioxamine

1989 • 92 citations

The reaction of ferrous EDTA with hydrogen peroxide: Evidence against hydroxyl radical formation

1985 • 91 citations

Scatchard analysis of methane sulfinic acid production from dimethyl sulfoxide: A method to quantify hydroxyl radical formation in physiologic systems

1989 • 90 citations

Free Radicals formed during the Oxidation and Reduction of Peroxides

1962 • 89 citations

An experimental model for hydrogen peroxide–induced tissue damage. Effects of a single inflammatory mediator on (peri)articular tissues

1986 • 89 citations

Excretion, Metabolism and Tissue Distribution of A Spin Trapping Agent, α-Phenyl-N-Tert-Butyl-Nitrone (Pbn) in Rats

1990 • 88 citations

Inhibition of proteoglycan synthesis by hydrogen peroxide in cultured bovine articular cartilage

1985 • 87 citations

Reactive oxygen species, antioxidants, and acquired immunodeficiency syndrome. Sense or speculation?

1991 • 87 citations

A survey of chemicals inducing lipid peroxidation in biological systems

1987 • 84 citations

Aromatic hydroxylation of phenylalanine as an assay for hydroxyl radicals: Application to activated human neutrophils and to the heme protein leghemoglobin

1988 • 84 citations

Analysis of methylated and oxidized purines in urine by capillary gas chromatography-mass spectrometry

1989 • 83 citations

Chronic granulomatous disease.

1990 • 82 citations

Age influence on oxidative events during brain ischemia/reperfusion

1991 • 81 citations

The neonatal erythrocyte and its oxidative susceptibility.

1989 • 81 citations

Studies of the limited degradation of mucus glycoproteins. The mechanism of the peroxide reaction

1985 • 79 citations

Bleomycin-detectable iron in knee-joint synovial fluid from arthritic patients and its relationship to the extracellular antioxidant activities of caeruloplasmin, transferrin and lactoferrin

1987 • 78 citations

Enzymatic recycling of oxidized ascorbate in pig heart: One-electron vs two-electron pathway

1991 • 78 citations

MECHANISM OF EXACERBATION OF RHEUMATOID SYNOVITIS BY TOTAL-DOSE IRON-DEXTRAN INFUSION: IN-VIVO DEMONSTRATION OF IRON-PROMOTED OXIDANT STRESS

1987 • 78 citations

Iron-mediated radical reactions upon reperfusion contribute to myocardial "stunning"

1990 • 77 citations

Production of singlet oxygen-derived hydroxyl radical adducts during merocyanine-540-mediated photosensitization: Analysis by ESR-spin trapping and HPLC with electrochemical detection

1991 • 75 citations

N-Acetylcysteine Inhibits Latent HIV Expression in Chronically Infected Cells

1991 • 75 citations

Enhancement of bleomycin—iron free radical damage to DNA by antioxidants and their inhibition of lipid peroxidation

1981 • 75 citations

Light activation of fructose bisphosphatase in isolated spinach chloroplasts and deactivation by hydrogen peroxide

1981 • 73 citations

Superoxide-Dependent Formation of Hydroxyl Radicals from Ferric-Complexes and Hydrogen Peroxide: An Evaluation of Fourteen Iron Chelators

1990 • 72 citations

Oxygen-radical production during inflammation may be limited by oxygen concentration

1984 • 71 citations

Invited Review: Repair of DNA Damage Induced by Reactive Oxygen Species

1991 • 71 citations

Genetic and biochemical characterization of Cu,Zn superoxide dismutase mutants in Saccharomyces cerevisiae

1991 • 70 citations

Oxidative damage to lipids within the inflamed human joint provides evidence of radical-mediated hypoxic-reperfusion injury

1991 • 69 citations

Vision and hearing during deferoxamine therapy

1990 • 69 citations

Membrane proteins are critical targets in free radical mediated cytolysis

1988 • 69 citations

Effects of Oxidative Stress Caused by Hyperoxia and Diquat. A Study in Isolated Hepatocytes

1986 • 64 citations

Detection of ferryl myoglobin in the isolated ischemic rat heart

1990 • 64 citations

In Vitro Screening of Iron Chelators Using Models of Free Radical Damage

1986 • 61 citations

The study of iron mobilisation from transferrin using α-ketohydroxy heteroaromatic chelators

1986 • 61 citations

An E.S.R. Investigation of the Reactive Intermediate Generated in the Reaction Between Fe^IIand H₂O₂in Aqueous Solution. Direct Evidence for the Formation of the Hydroxyl Radical

1992 • 57 citations

Human Fibroblasts Release Reactive Oxygen Species in Response to Treatment with Synovial Fluids from Patients Suffering from Arthritis

1990 • 55 citations

Hypothesis: is lung disease after silicate inhalation caused by oxidant generation?

1990 • 54 citations

Phagocytic Cell-Derived Inflammatory Mediators and Lung Disease

1987 • 52 citations

Lipid peroxidation in human diseases: Evidence of red cell oxidative stress after circulatory shock

1989 • 52 citations

The pharmacology of ebselen

1991 • 50 citations

Identification of a thioredoxin — related protein associated with plasma membranes

1991 • 50 citations

Human urate oxidase gene: Cloning and partial sequence analysis reveal a stop codon within the fifth exon

1990 • 50 citations

High-performance liquid chromatographic detection of hydroxylated benzoic acids as an indirect measure of hydroxyl radical in heart: its possible link with the myocardial reperusion injury

1991 • 50 citations

Xanthine oxidoreductase is present in human synovium.

1987 • 50 citations

Iron release and erythrocyte damage in allyl alcohol intoxication in mice

1990 • 48 citations

Down syndrome clinical symptoms are manifested in transfected cells and transgenic mice overexpressing the human Cu/Zn-superoxide dismutase gene.

1990 • 48 citations

Identification and partial characterization of angiogenesis bioactivity in the lower respiratory tract after acute lung injury.

1991 • 47 citations

Review Article the B Lymphocyte: A Newly Recognized Source of Reactive Oxygen Species with Immunoregulatory Potential

1990 • 47 citations

A pathological role for damaged hyaluronan in synovitis.

1991 • 47 citations

Iron mobilisation from lactoferrin by chelators at physiological pH

1986 • 45 citations

Effects of overproduction of superoxide dismutase on the toxicity of paraquat toward Escherichia coli

1991 • 44 citations

Spontaneous chemiluminescence of human breath. Spectrum, lifetime, temporal distribution, and correlation with peroxide.

1983 • 44 citations

Apparent inactivation of α1-antiroteinase by sulphur-containing radicals derived from penicillamine

1989 • 42 citations

Hematin- and peroxide-catalyzed peroxidation of phospholipid liposomes

1991 • 39 citations

The Nature of the Primary Oxidants in Oxidations Mediated by Metal Ions

1982 • 39 citations

The Myoglobin-Derived Radical Formed on Reaction of Metmyoglobin with Hydrogen Peroxide is not a Tyrosine Peroxyl Radical

1992 • 37 citations

Quantitative determination of hydroxy fatty acids as an indicator of in vivo lipid peroxidation: Gas chromatography-mass spectrometry methods

1991 • 37 citations

Oxygen radicals and lung injury

1991 • 36 citations

Studies of Hypervalent Iron

1991 • 34 citations

Conjugated diene and trans fatty acids in tissue lipids of rats fed an hepatocarcinogenic choline-devoid diet

1990 • 34 citations

Detecting irradiated foods: use of hydroxyl radical biomarkers.

1988 • 33 citations

Copper loading of hearts increases postischemic reperfusion injury.

1991 • 33 citations

Esr Investigations of the Reactions of Radiation-Produced Thiyl and DNA Peroxyl Radicals: Formation of Sulfoxyl Radicals

1989 • 33 citations

The Cupric Ion Catalysis of the Cleavage of γ-Globulin and Other Proteins by Hydrogen Peroxide

1961 • 32 citations

Vitamin E supplementation and periventricular hemorrhage in the newborn

1991 • 32 citations

Spin Trapping and Associated Vocabulary

1990 • 31 citations

Free radical modification of prosthetic heme groups

1990 • 29 citations

Muscle Cell Leakage of Myoglobin After Long-Term Exercise and Relation to the Individual Performances

1986 • 29 citations

The Kinetics of the Reaction of Ferritin with Superoxide

1987 • 28 citations

Electron spin resonance studies. Part XIV. Hydroxylation. Part III. Reactions of anisole, acetanilide, fluorobenzene, and some phenols with the titanium(<scp>III</scp>)–hydrogen peroxide system

1968 • 28 citations

Effects of antimalarial drugs on interleukin 1-induced cartilage proteoglycan degradation in-vitro

1986 • 25 citations

The Molecular Genetics of Superoxide Dismutase inE. Coli

1991 • 24 citations

Radio-Isotopic Determination of Subnanomolar Amounts of Peroxide

1989 • 22 citations

Association of Antioxidant Systems in the Protection of Human Fibroblasts Against Oxygen Derived Free Radicals

1991 • 22 citations

Hyperoxia and salicylate metabolism in rats

1990 • 22 citations

Hydroxylation of phenylalanine by the hypoxanthine-xanthine oxidase system.

1984 • 20 citations

Hemoglobin potentiates oxidant injury in isolated rat lungs

1991 • 20 citations

Oxygen radical production by transformed B lymphocytes

1991 • 18 citations

Cytokines and sepsis: What are the therapeutic implications?

1991 • 15 citations

Oxidation of articular cartilage glyceraldehyde-3-phosphate dehydrogenase (G3PDH) occurs in vivo during carrageenin-induced arthritis

1991 • 14 citations

Chemical models and radiation damage

1985 • 14 citations

The role of metal ions in ischemia/reperfusion injury in skin flaps

1989 • 13 citations

Spin-trapping of superoxide by 5,5-dimethyl-1-pyrroline N-oxide: Application to isolated perfused organs

1990 • 12 citations

Therapeutic Usages of Oxygen Radical Scavengers in Human Diseases: Myths and Realities

1991 • 11 citations

Demonstration of hydroxyl radical generation in stunned' myocardium of intact dogs using aromatic hydroxylation of phenylalanine

1991 • 6 citations