Central nervous system trauma and strokeII. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation

Cerebral vasospasm following aneurysmal subarachnoid hemorrhage.

1985 • 1,106 citations

Free radicals in cerebral ischemia.

1978 • 589 citations

Efficacy of Methylprednisolone in Acute Spinal Cord Injury

1984 • 546 citations

PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH.

1986 • 489 citations

Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation.

1987 • 474 citations

Methylprednisolone and neurological function 1 year after spinal cord injury

1985 • 332 citations

Effect of high-dose corticosteroid therapy on blood flow, evoked potentials, and extracellular calcium in experimental spinal injury

1982 • 319 citations

Effects of the 21-aminosteroid U74006F on experimental head injury in mice

1988 • 296 citations

Functional, morphological, and metabolic abnormalities of the cerebral microcirculation after concussive brain injury in cats.

1980 • 290 citations

Lipid Peroxidation In Vivo Induced by Reversible Global Ischemia in Rat Brain

1984 • 283 citations

Transient Formation of Superoxide Radicals in Polyunsaturated Fatty Acid‐Induced Brain Swelling

1980 • 267 citations

Effects of intravenous methylprednisolone on spinal cord lipid peroxidation and (Na+ + K+)-ATPase activity

1982 • 249 citations

Cerebral Arteriolar Damage by Arachidonic Acid and Prostaglandin G ₂

1980 • 245 citations

Oxygen Radicals in Brain Injury

1986 • 244 citations

A pharmacological analysis of the pathophysiological mechanisms of posttraumatic spinal cord ischemia

1986 • 228 citations

Inhibition by free radical scavengers and by cyclooxygenase inhibitors of pial arteriolar abnormalities from concussive brain injury in cats.

1981 • 222 citations

Influence of transient ischemia on lipid-soluble antioxidants, free fatty acids and energy metabolites in rat brain

1982 • 221 citations

High-dose glucocorticoid treatment improves neurological recovery in head-injured mice

1985 • 219 citations

Glutathione and Ascorbate During Ischemia and Postischemic Reperfusion in Rat Brain

1980 • 218 citations

Endorphins in experimental spinal injury: Therapeutic effect of naloxone

1981 • 214 citations

A possible role of lipid peroxidation in cellular damages caused by cerebral ischemia and the protective effect of alpha-tocopherol administration.

1983 • 214 citations

Lipid Hydrolysis and Peroxidation in Injured Spinal Cord: Partial Protection with Methylprednisolone or Vitamin E and Selenium

1985 • 206 citations

Effect of naloxone on posttraumatic ischemia in experimental spinal contusion

1981 • 202 citations

Extracellular calcium activity in the injured spinal cord

1983 • 196 citations

Evaluation of an intensive methylprednisolone sodium succinate dosing regimen in experimental spinal cord injury

1987 • 195 citations

Effects of a single large dose of methylprednisolone sodium succinate on experimental posttraumatic spinal cord ischemia

1984 • 193 citations

Extracellular calcium ionic activity in experimental spinal cord contusion

1982 • 193 citations

Influence of Complete and Pronounced Incomplete Cerebral Ischemia and Subsequent Recirculation on Cortical Concentrations of Oxidized and Reduced Glutathione in the Rat

1980 • 188 citations

Further studies on free-radical pathology in the major central nervous system disorders: effect of very high doses of methylprednisolone on the functional outcome, morphology, and chemistry of experimental spinal cord impact injury

1982 • 187 citations

Cyclooxygenase Products of Arachidonic Acid Metabolism in Cat Cerebral Cortex After Experimental Concussive Brain Injury

1981 • 167 citations

Effects of Methylprednisolone and the Combination of α‐Tocopherol and Selenium on Arachidonic Acid Metabolism and Lipid Peroxidation in Traumatized Spinal Cord Tissue

1987 • 166 citations

Lipid Peroxidation‐Induced Inhibition of γ‐Aminobutyric Acid Uptake in Rat Brain Synaptosomes: Protection by Glucocorticoids

1985 • 161 citations

Lactate and pyruvate metabolism in injured cat spinal cord before and after a single large intravenous dose of methylprednisolone

1983 • 158 citations

Leukotrienes increase blood‐brain barrier permeability following intraparenchymal injections in rats

1985 • 155 citations

KINETICS OF TISSUE α‐TOCOPHEROL UPTAKE AND DEPLETION FOLLOWING ADMINISTRATION OF HIGH LEVELS OF VITAMIN E

1982 • 153 citations

Alteration of thrornboxane and prostacyclin levels in experimental spinal cord injury

1985 • 148 citations

Prevention of chronic experimental cerebral vasospasm with ibuprofen and high-dose methylprednisolone

1983 • 146 citations

Increased phospholipase C activity after experimental brain injury

1982 • 143 citations

Role of Lipid Peroxidation in Post-Traumatic Spinal Cord Degeneration: A Review

1986 • 141 citations

Protective effects of combined superoxide dismutase and deferoxamine on recovery of cerebral blood flow and function after cardiac arrest in dogs.

1987 • 141 citations

Attenuation of postischemic cerebral hypoperfusion by the 21-aminosteroid U74006F.

1988 • 139 citations

Selective hemoglobin inhibition of endothelium-dependent vasodilation of rabbit basilar artery

1986 • 137 citations

Acute effects of intravenous glucocorticoid pretreatment on the in vitro peroxidation of cat spinal cord tissue

1981 • 133 citations

Axonal physiology of chronic spinal cord injury in the cat: Intracellular recording in vitro

1983 • 132 citations

Postischemic Cerebral Lipid Peroxidation In Vitro: Modification by Dietary Vitamin E

1985 • 129 citations

Lipid Peroxidation as a Cause of Cerebral Vasospasm

1980 • 123 citations

Experimental spinal cord injury: treatment with naloxone.

1982 • 122 citations

Inhibition of Na+-K+-activated ATPase activity following experimental spinal cord trauma

1978 • 110 citations

A nonglucocorticoid steroid analog of methylprednisolone duplicates its high-dose pharmacology in models of central nervous system trauma and neuronal membrane damage.

1987 • 98 citations

Chemiluminescence in hypoxic brain--the second report: cerebral protective effect of mannitol, vitamin E and glucocorticoid.

1985 • 98 citations

Iron-induced lipid peroxidation in spinal cord: Protection with mannitol and methylprednisolone

1985 • 86 citations

Altered levels of PGF in cat spinal cord tissue following traumatic injury

1976 • 84 citations

Interactions of lipid hydroperoxides with eicosanoid biosynthesis

1985 • 73 citations

Effects of antiperoxidants on FeCl2-induced lipid peroxidation and focal edema in rat brain

1984 • 73 citations

Role of monoamines in experimental spinal cord injury in rats

1985 • 71 citations

Experimental evaluation of the beneficial effect of an antioxidant on cerebral vasospasm

1984 • 67 citations

Loss of Ascorbic Acid from Injured Feline Spinal Cord

1983 • 60 citations

Uptake and elimination of methylprednisolone from contused cat spinal cord following intravenous injection of the sodium succinate ester

1983 • 52 citations

Lipid antioxidant properties of naloxone in vitro

1981 • 48 citations

Naloxone inhibits superoxide release from human neutrophils

1985 • 47 citations

Oxygen Radicals from Arachidonate Metabolism in Abnormal Vascular Responses

1987 • 46 citations

Response of chronic experimental cerebral vasospasm to methylprednisolone and dexamethasone

1984 • 42 citations

PARAMAGNETIC SPECIES AND RADICAL PRODUCTS IN CAT SPINAL CORD *

1973 • 41 citations

Morphometric assessment of drug effects in experimental spinal cord injury

1986 • 40 citations

The protective effect of vitamin E on cerebral ischemia

1984 • 39 citations

Compdon‐induced brain edem

1983 • 39 citations

Oxygen Free‐Radical Reduction of Brain Capillary Rubidium Uptake

1986 • 36 citations

Motor Nerve Terminals As the Site of Initial Functional Changes After Denervation

1969 • 35 citations

Changes in synaptic transmission produced by hydrogen peroxide

1986 • 34 citations

Intensive anti-oxidant pretreatment retards motor nerve degeneration

1987 • 34 citations

Glucocorticoid preservation of motor nerve function during early degeneration

1977 • 34 citations

Production of Uric Acid in Cerebrospinal Fluid after Subarachnoid Hemorrhage in Dogs: Investigation of the Possible Role of Xanthine Oxidase in Chronic Vasospasm

1987 • 32 citations

The effects of chronic two-fold dietary vitamin E supplementation on subarachnoid hemorrhage-induced brain hypoperfusion

1987 • 30 citations

Attenuation of progressive brain hypoperfusion following experimental subarachnoid hemorrhage by large intravenous doses of methylprednisolone

1988 • 28 citations

REPERFUSION INDUCED FREE RADICAL FORMATION FOLLOWING GLOBAL ISCHEMIA

1987 • 28 citations

Post-Traumatic Spinal Cord Ischemia: Relationship to Injury Severity and Physiological Parameters

1987 • 24 citations

Role of Oxygen Free Radicals in Focal Brain Ischemia

1988 • 23 citations

Effect of α-tocopherol and free radicals on anoxic damage in the rat hippocampal slice

1987 • 22 citations

Beneficial action of glucocorticoid treatment on neuromuscular transmission during early motor nerve degeneration

1983 • 20 citations

Oxygen-Free Radicals: Potential Edema Mediators in Brain Injury

1985 • 20 citations

Methylprednisolone preservation of motor nerve function during early degeneration

1984 • 20 citations

Superoxide dismutase activity in experimental focal cerebral ischemia

1985 • 13 citations