Glutathione depleting agents and lipid peroxidation

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Glutathione peroxidase activity in selenium-deficient rat liver

1976 • 3,413 citations

Bromobenzene-Induced Liver Necrosis. Protective Role of Glutathione and Evidence for 3,4-Bromobenzene Oxide as the Hepatotoxic Metabolite

1974 • 3,074 citations

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.

1973 • 1,717 citations

Free Radical Mechanisms in Tissue Injury

1988 • 1,585 citations

Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.

1973 • 1,467 citations

Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

1970 • 1,464 citations

Glutathione peroxidase: A selenoenzyme

1973 • 1,358 citations

Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.

1973 • 1,174 citations

Carcinogenic Nitroso Compounds

1967 • 1,109 citations

Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids

1980 • 1,094 citations

The selenoenzyme phospholipid hydroperoxide glutathione peroxidase

1985 • 961 citations

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

1982 • 893 citations

Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides

1982 • 779 citations

HEMOGLOBIN CATABOLISM

1957 • 774 citations

Carbon Tetrachloride Hepatotoxicity: An Example of Lethal Cleavage

1973 • 729 citations

Separation and characterization of the aldehydic products of lipid peroxidation stimulated by ADP-Fe2+ in rat liver microsomes

1982 • 614 citations

PLASMA-PARACETAMOL HALF-LIFE AND HEPATIC NECROSIS IN PATIENTS WITH PARACETAMOL OVERDOSAGE

1971 • 610 citations

Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds

1972 • 593 citations

Lipid peroxidation and cellular damage in toxic liver injury.

1985 • 556 citations

Bleb Formation in Hepatocytes During Drug Metabolism Is Caused by Disturbances in Thiol and Calcium Ion Homeostasis

1982 • 553 citations

Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heart

1980 • 550 citations

Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.

1973 • 500 citations

Mechanisms of chemical carcinogenesis: nature of proximate carcinogens and interactions with macromolecules.

1966 • 489 citations

An intracellular GSH-peroxidase with a lipid peroxide substrate

1968 • 450 citations

Status of the mitochondrial pool of glutathione in the isolated hepatocyte.

1982 • 440 citations

Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes

1984 • 411 citations

The mechanism of NADPH-dependent lipid peroxidation. The propagation of lipid peroxidation.

1979 • 390 citations

Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis

1984 • 376 citations

Separation and characterization of the aldehydic products of lipid peroxidation stimulated by carbon tetrachloride or ADP-iron in isolated rat hepatocytes and rat liver microsomal suspensions

1985 • 362 citations

An enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone‐exposed rats

1972 • 350 citations

Energy-dependent calcium sequestration activity in rat liver microsomes.

1975 • 342 citations

Biochemical Mechanisms of Drug Toxicity

1974 • 337 citations

One-electron-transfer reactions in biochemical systems V. Difference in the mechanism of quinone reduction by the NADH dehydrogenase and the NAD(P)H dehydrogenase (DT-diaphorase)

1970 • 335 citations

Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent formation and breakdown of hydrogen peroxide during mixed function oxidation reactions in liver microsomes

1975 • 330 citations

Enzyme-catalysed conjugations of glutathione with unsaturated compounds

1967 • 324 citations

Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo

1979 • 298 citations

Metabolic Activation of Drugs to Toxic Substances

1975 • 281 citations

Mechanistic aspects of enhanced lipid peroxidation following glutathione depletion in vivo

1981 • 276 citations

Role of oxygen radicals in cardiac injury due to reoxygenation*

1984 • 276 citations

Biological disulfides: the third messenger? Modulation of phosphofructokinase activity by thiol/disulfide exchange.

1982 • 265 citations

Lipid peroxidation and cellular damage in extrahepatic tissues of bromobenzene-intoxicated mice.

1986 • 264 citations

Aldehydes in biological systems

1977 • 259 citations

Properties and Regulation of Glutathione Peroxidase

1970 • 259 citations

Lipoperoxidation of Lung Lipids in Rats Exposed to Nitrogen Dioxide

1968 • 251 citations

Altered thiol and calcium homeostasis in oxidative hepatocellular injury

1985 • 249 citations

Biochemical Mechanisms in Chemical-Induced Lung Injury: Roles of Metabolic Activation

1980 • 246 citations

Oxidation of glutathione during hydroperoxide metabolism

1984 • 243 citations

A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity—I correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity

1974 • 225 citations

The role of glutathione in the retention of Ca2+ by liver mitochondria.

1984 • 223 citations

Drug-induced lipid peroxidation in mice—I Modulation by monooxegenase activity, glutathione and selenium status

1981 • 222 citations

Protective role of the glutathione redox cycle against adriamycin-mediated toxicity in isolated hepatocytes

1981 • 221 citations

Role of detoxifying enzymes in bromobenzene-induced liver necrosis.

1973 • 212 citations

The measurement of lipid peroxidation in isolated hepatocytes

1982 • 206 citations

Reduction of linolenic acid hydroperoxide by a glutathione peroxidase

1969 • 197 citations

Effect of Superoxide Generation and Dismutation on Hydroxylation Reactions Catalyzed by Liver Microsomal Cytochrome P-450

1971 • 189 citations

Hepatic mitochondrial and cytosolic glutathione content and the subcellular distribution of GSH‐S‐transferases

1979 • 188 citations

Inactivation of glutathione reductase by 2-chloroethyl nitrosourea-derived isocyanates

1978 • 188 citations

Hydrogen peroxide formation and stoichiometry of hydroxylation reactions catalyzed by highly purified liver microsomal cytochrome P-450

1977 • 187 citations

Cytochrome P-450: Localization in Rabbit Lung

1980 • 179 citations

Depletion in vitro of mitochondrial glutathione in rat hepatocytes and enhancement of lipid peroxidation by adriamycin and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)

1983 • 177 citations

Inhibition of ATP-dependent microsomal Ca2+ sequestration during oxidative stress and its prevention by glutathione.

1983 • 176 citations

Critical role of sulfhydryl group(s) in ATP‐dependent Ca²⁺ sequestration by the plasma membrane fraction from rat liver

1983 • 172 citations

Glutathione Depletion in Isolated Hepatocytes: Its Relation to Lipid Peroxidation and Cell Damage

1979 • 168 citations

Peroxide removal by selenium-dependent and selenium-independent glutathione peroxidases in hemoglobin-free perfused rat liver.

1978 • 167 citations

Acetaminophen-induced hepatotoxicity

1981 • 164 citations

Ozone and Lipid Peroxidation

1969 • 164 citations

Centrolobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons

1973 • 162 citations

The metabolism of menadione impairs the ability of rat liver mitochondria to take up and retain calcium.

1982 • 159 citations

Liver glutathione depletion induced by bromobenzene, iodobenzene, and diethylmaleate poisoning and its relation to lipid peroxidation and necrosis.

1985 • 159 citations

Generation of superoxide anion as a source of hydrogen peroxide in a reconstituted monooxygenase system

1978 • 155 citations

Autoxidation of polyunsaturated esters in water: chemical structure and biological activity of the products

1967 • 149 citations

Metabolism and Binding of Aromatic Hydrocarbons in the Lung

1973 • 148 citations

Bromobenzene Metabolism and Hepatic Necrosis

1971 • 141 citations

Mechanisms of cell injury in the killing of cultured hepatocytes by bromobenzene.

1982 • 135 citations

Pyridine‐nucleotide oxidation, Ca²⁺ cycling and membrane damage during tert‐butyl hydroperoxide metabolism by rat‐liver mitochondria

1984 • 135 citations

Drug metabolism as a cause of drug toxicity.

1973 • 133 citations

�ber die Wirkungen von Aldehyden auf gesunde und maligne Zellen, 3. Mitt.: Synthese von homologen 4-Hydroxy-2-alkenalen, II

1967 • 133 citations

Role of redox cycling and lipid peroxidation in bipyridyl herbicide cytotoxicity

1986 • 133 citations

Effects of diffusible products of peroxidation of rat liver microsomal lipids

1979 • 131 citations

The inhibitory effect of reduced glutathione on the lipid peroxidation of the microsomal fraction and mitochondria

1968 • 129 citations

Enzymes catalysing conjugations of glutathione with αβ-unsaturated carbonyl compounds

1968 • 126 citations

Quinone-stimulated superoxide formation by subcellular fractions, isolated hepatocytes, and other cells.

1981 • 119 citations

Increase in hepatic mixed disulphide and glutathione disulphide levels elicited by paraquat

1982 • 118 citations

Lipid Peroxidation in Isolated Hepatocytes

1975 • 118 citations

The effect of cobalt chloride administration on the synthesis of hepatic microsomal cytochrome P-450

1971 • 115 citations

Iron chelation prevents tissue injury following ischemia

1985 • 109 citations

Effects of 4-hydroxynonenal on isolated hepatocytes. Studies on chemiluminescence response, alkane production and glutathione status

1983 • 109 citations

Effects of the lipidperoxidation product 4-hydroxynonenal and related aldehydes on proliferation and viability of cultured ehrlich ascites tumor cells

1985 • 109 citations

A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity—II. Alterations in the kinetics of covalent binding

1974 • 107 citations

Increase in cytosolic Ca²⁺ concentration during t‐butyl hydroperoxide metabolism by isolated hepatocytes involves NADPH oxidation and mobilization of intracellular Ca²⁺ stores

1984 • 107 citations

Inhibition of microsomal drug metabolism by methylenedioxybenzenes

1968 • 101 citations

An ultrastructural and morphometric study of the liver of the lactating cow in starvation ketosis

1973 • 100 citations

Dissociation of cell death from covalent binding of paracetamol by flavones in a hepatocyte system

1982 • 98 citations

Acetaminophen hepatotoxicity

1983 • 96 citations

Further Studies on Lipid‐Peroxide Formation in Isolated Hepatocytes

1975 • 95 citations

Oxygen-mediated cell injury in the killing of cultured hepatocytes by acetaminophen

1985 • 93 citations

On the relationship between Ca²⁺ efflux and membrane damage during t‐butylhydroperoxide metabolism by liver mitochondria

1983 • 93 citations

On the role of thiol groups in the inhibition of liver microsomal ca2+ sequestration by toxic agents

1985 • 93 citations

Paracetamol-induced hepatic necrosis in the mouse—Relationship between covalent binding, hepatic glutathione depletion and the protective effect of α-mercaptopropionylglycine

1977 • 92 citations

Paracetamol-stimulated lipid peroxidation in isolated rat and mouse hepatocytes

1983 • 91 citations

Possible control of hydrogen peroxide production and degradation in microsomes during mixed function oxidation reaction

1973 • 90 citations

Some properties of mitochondrial glutathione

1975 • 86 citations

Rat liver microsomal NADPH-dependent release of iron from ferritin and lipid peroxidation

1985 • 84 citations

Extraction and partial characterization of dialysable products originating from the peroxidation of liver microsomal lipids and inhibiting microsomal glucose 6-phosphatase activity

1979 • 81 citations

Submolecular Biology and Cancer

1980 • 80 citations

The non-protein thiol of rat liver mitochondria

1974 • 77 citations

Detection of carbonyl functions in phospholipids of liver microsomes in CCl4- and BrCCl3-poisoned rats

1982 • 75 citations

Mechanism of renal necrosis induced by bromobenzene

1973 • 72 citations

The role of lipid peroxidation in the toxicity of foreign compounds to liver cells

1983 • 71 citations

Lipid peroxidation, protein thiols and calcium homeostasis in bromobenzene-induced liver damage

1987 • 69 citations

Inhibition of protein synthesis by carbonyl compounds (4-hydroxyalkenals) originating from the peroxidation of liver microsomal lipids

1981 • 65 citations

The role of iron in the paracetamol- and CCl4-induced lipid peroxidation and hepatotoxicity

1985 • 65 citations

Selective modification of the renal and the hepatic toxicities of chloroform by induction of drug-metabolizing enzyme systems in kidney and liver.

1978 • 64 citations

Metabolic activation and hepatotoxicity

1978 • 62 citations

Detection of 4-hydroxynonenal and other lipid peroxidation products in the liver of bromobenzene-poisoned mice

1986 • 62 citations

An in vitro model of liver injury using Paracetamol treatment of liver slices and prevention of injury by some antioxidants

1978 • 62 citations

Fuscin, an inhibitor of mitochondrial SH-dependent transport-linked functions

1973 • 61 citations

Metabolic activation and hepatotoxicity

1978 • 58 citations

An essential role of cytosolic thioltransferase in protection of pyruvate kinase from rabbit liver against oxidative inactivation

1983 • 57 citations

Hepatic microsomal dealkylations. Inhibition by a tyrosine-copper (II) complex provided with superoxide dismutase activity.

1977 • 55 citations

Oxygen dependence of CCl4-induced lipid peroxidation in vitro and in vivo

1980 • 52 citations

The Metabolism of Ethylene Dibromide in the Rat I. Identification of Detoxification Products in Urine

1966 • 51 citations

Oxidation of reduced glutathione by subcellular fractions of rat liver

1966 • 49 citations

The mechanism of action of 4-hydroxynonenal in cell injury

1984 • 48 citations

Inhibition of calcium sequestration activity of liver microsomes by 4-hydroxyalkenals originating from the peroxidation of liver microsomal lipids

1984 • 48 citations

The role of ortho-bromophenol in the nephrotoxicity of bromobenzene in rats

1984 • 48 citations

Studies in detoxication. 51. The determination of catechols in urine, and the formation of catechols in rabbits receiving halogenobenzenes and other compounds. Dihydroxylation in vivo

1953 • 48 citations

Depletion by 1,2-dibromoethane, 1,2-dibromo-3-chloropropane, tris(2,3-dibromopropyl)phosphate,and hexachloro-1,3-butadiene of reduced non-protein sulfhydryl groups in target and non-target organs

1981 • 47 citations

Formation of 4-aminophenoxyl free radical from the acetaminophen metabolite N-acetyl-p-benzoquinone imine.

1985 • 39 citations

Cytotoxic Effects of N‐Hydroxyparacetamol in Suspensions of Isolated Rat Hepatocytes

1982 • 37 citations

The critical steady-state hypoxic conditions in carbon tetrachloride-induced lipid peroxidation in rat liver microsomes

1984 • 36 citations

A prospective on covalent binding and toxicity

1977 • 34 citations

Toxicity of 1,2-dibromoethane in isolated hepatocytes: Role of lipid peroxidation

1984 • 34 citations

Drug-induced lipid peroxidation in mice—IV

1983 • 27 citations

Formation of lipoperoxide in brain edema induced by cold injury

1974 • 27 citations

Effect of substituents on in vitro metabolism and covalent binding of substituted bromobenzenes

1979 • 27 citations

Protection from paraquat-induced lung damage and lethality in adult rats pretreated with clofibrate

1982 • 26 citations

The Effect of Hepatic Metabolism on the Production and Toxicity of Reactive Metabolites in Extrahepatic Organs

1983 • 25 citations

Comparison of ethylene dibromide and carbon tetrachloride toxicity in rats and chicks: Blood and liver levels; lipid peroxidation

1972 • 25 citations

Wirkungen von Hydroxypentenal auf den Stoffwechsel von Krebs-und Normalzellen

1969 • 24 citations

Hepatic Lipid Peroxidation in Acute Fatal Human Carbon Tetrachloride Poisoning

1968 • 20 citations

Covalent binding of trans-stilbene to rat liver microsomes

1975 • 17 citations

Activation and detoxification of bromobenzene in extrahepatic tissues

1984 • 17 citations

Über die Reaktion von Δ9, 12-Linolsäureäthylester in Wasser, 4. Mitt.: Bildung wasserlöslicher Fettsäureester-Hydroperoxyde mit atmungs- und gärungshemmender Wirkung auf Tumorzellen und Hefe

1961 • 10 citations

The role of iron in the nadph-dependent lipid peroxidation due to glutathione depletion by phorone

1984 • 10 citations

�ber die Reaktion von ?9, 12-Linols�ureester in wasser, 6. Mitt.: Chromatographische Untersuchungen �ber die Zusammensetzung des Pr�parates ?LHPO? und die Isolierung der einzelnen tumorwirksamen Hydroperoxydkomponenten

1963 • 7 citations