Mechanisms of oxidant injury of cells

Mechanisms of oxidant-mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide.

1988 • 614 citations

Functions of glutathione. Biochemical, physiological, toxicological and clinical aspects

1984 • 595 citations

Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells.

1981 • 587 citations

Bleb Formation in Hepatocytes During Drug Metabolism Is Caused by Disturbances in Thiol and Calcium Ion Homeostasis

1982 • 553 citations

Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity.

1979 • 538 citations

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

1986 • 520 citations

Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase.

1986 • 466 citations

Oxidant-induced DNA damage of target cells.

1988 • 382 citations

Glutathione redox cycle protects cultured endothelial cells against lysis by extracellularly generated hydrogen peroxide.

1984 • 334 citations

Regulation of intracellular calcium compartmentation: studies with isolated hepatocytes and t-butyl hydroperoxide.

1982 • 303 citations

Alterations in adenosine triphosphate and energy charge in cultured endothelial and P388D1 cells after oxidant injury.

1985 • 268 citations

Hydrogen peroxide causes the fatal injury to human fibroblasts exposed to oxygen radicals.

1981 • 260 citations

Oxidation in the NADP system and release of GSSG from hemoglobin‐free perfused rat liver during peroxidatic oxidation of glutathione by hydroperoxides

1972 • 257 citations

Glutathione depletion sensitizes tumor cells to oxidative cytolysis.

1982 • 214 citations

Cytoskeletal and morphologic impact of cellular oxidant injury.

1986 • 190 citations

Glutathione cycle activity and pyridine nucleotide levels in oxidant-induced injury of cells.

1985 • 162 citations

Damage to the bases in DNA induced by stimulated human neutrophils.

1989 • 139 citations

Protection of mammalian cells by o-phenanthroline from lethal and DNA-damaging effects produced by active oxygen species

1985 • 139 citations

Role of oxidants in DNA damage. Hydroxyl radical mediates the synergistic DNA damaging effects of asbestos and cigarette smoke.

1987 • 130 citations

The production of DNA strand breaks in human leukocytes by superoxide anion may involve a metabolic process.

1985 • 124 citations

Intracellular calcium homeostasis during hydrogen peroxide injury to cultured P388D₁ cells

1986 • 120 citations

DNA-ferrous iron catalyzed hydroxyl free radical formation from hydrogen peroxide

1981 • 108 citations

Radiation-like modification of bases in DNA exposed to tumor promoter-activated polymorphonuclear leukocytes.

1986 • 106 citations

ATP and microfilaments in cellular oxidant injury.

1988 • 97 citations

Clastogenic action of hydroperoxy-5,8,11,13-icosatetraenoic acids on the mouse embryo fibroblasts C3H/10T1/2.

1987 • 82 citations

Hepatic calcium efflux during cytochrome P-450-dependent drug oxidations at the endoplasmic reticulum in intact liver.

1981 • 57 citations