Free Radicals in Medicine. II. Involvement in Human Disease

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Radiobiology for the Radiologist.

1974 • 3,582 citations

Dietary Carcinogens and Anticarcinogens

1983 • 3,028 citations

Pulmonary Disease Following Respirator Therapy of Hyaline-Membrane Disease

1967 • 2,888 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

1980 • 2,099 citations

The aging process.

1981 • 1,871 citations

Free-radical chemistry of cigarette smoke and its toxicological implications.

1985 • 1,351 citations

Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.

1982 • 1,241 citations

Superoxide radicals in feline intestinal ischemia

1981 • 1,213 citations

The Reduction of Cytochrome c by Milk Xanthine Oxidase

1968 • 1,201 citations

Adriamycin: The Role of Lipid Peroxidation in Cardiac Toxicity and Tumor Response

1977 • 1,116 citations

Role of superoxide dismutase in cancer: a review.

1979 • 976 citations

Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

1984 • 915 citations

Oxygen Metabolism and the Toxic Properties of Phagocytes

1980 • 886 citations

Xanthine oxidase as a source of free radical damage in myocardial ischemia

1985 • 678 citations

Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen.

1980 • 678 citations

The free radical pathology and the microcirculation in the major central nervous system disorders.

1980 • 660 citations

State of the Art

1983 • 655 citations

Release of Inflammatory Mediators from Stimulated Neutrophils

1980 • 649 citations

Replacement Therapy for Alpha₁-Antitrypsin Deficiency Associated with Emphysema

1987 • 640 citations

Probucol inhibits oxidative modification of low density lipoprotein.

1986 • 633 citations

ASSOCIATION OF COMPLEMENT ACTIVATION AND ELEVATED PLASMA-C5a WITH ADULT RESPIRATORY DISTRESS SYNDROME

1980 • 561 citations

Medical Treatment of Osteoarthritis

1965 • 554 citations

Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heart

1980 • 550 citations

Lipoprotein oxidation and lipoprotein-induced cytotoxicity.

1983 • 545 citations

Elastolytic Activity in Pulmonary Lavage Fluid from Patients with Adult Respiratory-Distress Syndrome

1981 • 528 citations

Leukocytes and the Risk of Ischemic Diseases

1987 • 525 citations

The role of lipid peroxidation in pathogenesis of ischemic damage and the antioxidant protection of the heart

1982 • 523 citations

Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase.

1984 • 478 citations

Superoxide dismutase and pulmonary oxygen toxicity

1974 • 462 citations

Abrupt reoxygenation of the anoxic potassium-arrested perfused rat heart: A study of myocardial enzyme release

1973 • 443 citations

The effect of hyperoxia on superoxide production by lung submitochondrial particles

1982 • 442 citations

Prevention by granulocyte depletion of increased vascular permeability of sheep lung following endotoxemia.

1981 • 426 citations

Pathological mechanisms in carbon tetrachloride hepatotoxicity

1985 • 422 citations

Oxygen Free Radicals Linked to Many Diseases

1987 • 399 citations

George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury.

1985 • 393 citations

Morphologic Changes in Pulmonary Oxygen Toxicity

1986 • 393 citations

Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases.

1984 • 392 citations

Oxygen toxicity in neonatal and adult animals of various species

1978 • 386 citations

Superoxide dismutase: correlation with life-span and specific metabolic rate in primate species.

1980 • 385 citations

Adult Respiratory Distress Syndrome in Patients with Severe Neutropenia

1986 • 381 citations

Normobaric Oxygen Toxicity of the Lung

1980 • 375 citations

Electron-spin resonance study of mainstream and sidestream cigarette smoke: nature of the free radicals in gas-phase smoke and in cigarette tar.

1983 • 373 citations

The pathophysiology of superoxide: roles in inflammation and ischemia

1982 • 368 citations

Effect of oxygen‐derived free radicals on hyaluronic acid

1980 • 368 citations

Role of oxygen-derived free radicals in digestive tract diseases.

1983 • 362 citations

Studies on the Pathogenesis of the Adult Respiratory Distress Syndrome

1982 • 359 citations

Superoxide dismutase plus catalase enhances the efficacy of hypothermic cardioplegia to protect the globally ischemic, reperfused heart

1982 • 355 citations

Reduction in experimental infarct size by recombinant human superoxide dismutase: insights into the pathophysiology of reperfusion injury.

1986 • 344 citations

Hyperoxia increases H2O2 release by lung mitochondria and microsomes

1982 • 336 citations

Oxidative stress on lens and cataract formation: role of light and oxygen

1984 • 305 citations

The pathological effects due to increase of oxygen tension in the air breathed

1899 • 295 citations

Pulmonary Oxygen Toxicity

1985 • 293 citations

Functional, morphological, and metabolic abnormalities of the cerebral microcirculation after concussive brain injury in cats.

1980 • 290 citations

Free-radical oxidation (peroxidation) products in serum and synovial fluid in rheumatoid arthritis.

1981 • 281 citations

Chronic Granulomatous Disease

1983 • 266 citations

Stimulated Human Phagocytes Produce Cytogenetic Changes in Cultured Mammalian Cells

1983 • 262 citations

Xanthine oxidase inhibitors attenuate ischemia-induced vascular permeability changes in the cat intestine

1986 • 262 citations

PULMONARY HEART-FAILURE

1947 • 262 citations

Granulocytes mediate acute edematous lung injury in rabbits and in isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals.

1982 • 257 citations

The Role of Oxygen-free Radicals in Ischemic Tissue Injury in Island Skin Flaps

1983 • 249 citations

Biochemical mechanisms accounting for the toxic action of oxygen on living organisms: The key role of superoxide dismutase

1978 • 249 citations

Endothelial cell-derived chemotactic activity for mouse peritoneal macrophages and the effects of modified forms of low density lipoprotein.

1985 • 249 citations

A Reexamination of the Role of Oxygen in Retrolental Fibroplasia

1984 • 248 citations

Retrolental Fibroplasia: Efficacy of Vitamin E in a Double-Blind Clinical Study of Preterm Infants

1981 • 241 citations

Role of oxygen free radicals in shock, ischemia, and organ preservation.

1983 • 238 citations

Oxygen toxicity

1980 • 238 citations

The independent effects of oxygen radical scavengers on canine infarct size. Reduction by superoxide dismutase but not catalase.

1985 • 234 citations

Oxygen-radical-mediated permeability edema and vasoconstriction in isolated perfused rabbit lungs.

1982 • 222 citations

Oxygen metabolites stimulate thromboxane production and vasoconstriction in isolated saline-perfused rabbit lungs.

1984 • 219 citations

Mechanism for the inflammatory response in primate lungs. Demonstration and partial characterization of an alveolar macrophage-derived chemotactic factor with preferential activity for polymorphonuclear leukocytes.

1977 • 215 citations

Neutrophils Kill Pulmonary Endothelial Cells by a Hydrogen-Peroxide-Dependent Pathway

1984 • 213 citations

Active oxygen acts as a promoter of transformation in mouse embryo C3H/10T1/2/C18 fibroblasts.

1984 • 208 citations

Inhibition of surgically induced ischemia/reperfusion injury by oxygen free radical scavengers

1983 • 207 citations

Tumour promoter phorbol-12-myristate-13-acetate induces chromosomal damage via indirect action

1981 • 205 citations

Relation of Smoking and Age to Emphysema

1972 • 201 citations

Oxidant injury of lung parenchymal cells.

1981 • 185 citations

LIPID PEROXIDATION IN RELATION TO PROSTACYCLIN AND THROMBOXANE PHYSIOLOGY AND PATHOPHYSIOLOGY

1983 • 184 citations

Responses of the ischemic myocardium to allopurinol

1971 • 183 citations

Proton and free oxygen radical interaction with the calcium transport system of cardiac sarcoplasmic reticulum

1981 • 179 citations

Self-perpetuating mechanisms of immunoglobulin G aggregation in rheumatoid inflammation.

1985 • 175 citations

Role of radical cations in aromatic hydrocarbon carcinogenesis.

1985 • 174 citations

Amelioration of Bronchopulmonary Dysplasia after Vitamin E Administration

1978 • 174 citations

THE ROLE OF OXYGEN FREE RADICALS IN MEDIATING THE REPERFUSION INJURY OF COLD-PRESERVED ISCHEMIC KIDNEYS1,2

1985 • 171 citations

Protection Against Lethal Hyperoxia by Tracheal Insufflation of Erythrocytes: Role of Red Cell Glutathione

1985 • 169 citations

Reduction of the edema of acute hyperoxic lung injury by granulocyte depletion

1982 • 168 citations

Persons at High Risk of Cancer. An Approach to Cancer Etiology and Control

1976 • 164 citations

NEUTROPHIL DYSFUNCTION, CHRONIC GRANULOMATOUS DISEASE, AND NON-SPHEROCYTIC HÆMOLYTIC ANÆMIA CAUSED BY COMPLETE DEFICIENCY OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE

1973 • 163 citations

Metabolism and action of anti-cancer drugs

1987 • 161 citations

Oxygen radicals as effectors of cartilage destruction. Direct degradative effect on matrix components and indirect action via activation of latent collagenase from polymorphonuclear leukocytes

1986 • 161 citations

Role of oxygen-derived free radicals in digestive tract diseases

1984 • 157 citations

Alpha1-antitrypsin and its deficiency.

1974 • 156 citations

Direct effects of E coli endotoxin on structure and permeability of pulmonary endothelial monolayers and the endothelial layer of intimal explants.

1986 • 149 citations

A Reevaluation of the Roles of the O2-Dependent and O2-Independent Microbicidal Systems of Phagocytes

1983 • 143 citations

Prevention of bronchopulmonary dysplasia by administration of bovine superoxide dismutase in preterm infants with respiratory distress syndrome

1984 • 143 citations

Protection against pulmonary oxygen toxicity in rats by the intratracheal administration of liposome-encapsulated superoxide dismutase or catalase.

1985 • 143 citations

Beneficial effect of allopurinol in liver ischemia.

1985 • 142 citations

Effect of allopurinol on hemorrhagic shock

1969 • 140 citations

The Pulmonary-Alveolar Macrophage

1979 • 134 citations

Role of Free Radicals in Lung Injury

1986 • 132 citations

Mechanism of cerebral arteriolar abnormalities after acute hypertension

1981 • 131 citations

Effects of oxygen radicals on cerebral arterioles

1985 • 128 citations

Effects of oxygen radical scavengers and antioxidants on phagocyte-induced mutagenesis.

1982 • 121 citations

Protection against Superoxide and Hydrogen Peroxide in Synovial Fluid from Rheumatoid Patients

1981 • 120 citations

Effect of Allopurinol on the Survival of Hyperemic Island Skin Flaps

1984 • 119 citations

Morphometric Analysis of the Lung in Prolonged Bronchopulmonary Dysplasia

1982 • 119 citations

Pathology of oxygen

1982 • 118 citations

Lung damage from cytotoxic drugs

1980 • 113 citations

Oxygen-Induced Alterations in Lung Vascular Development in the Newborn Rat

1983 • 113 citations

Patterns of accumulation of platelets and neutrophils in rat lungs during exposure to 100% and 85% oxygen.

1985 • 112 citations

Enzyme release during myocardial anoxia: A study of metabolic protection

1975 • 110 citations

The β-Adrenergic Blockade Withdrawal Phenomenon

1983 • 107 citations

Persons at high risk of cancer. An approach to cancer etiology and control

1977 • 106 citations

Role of oxygen free radicals in shock, ischemia, and organ preservation

1984 • 105 citations

Free-Radicals produced in Cigarette Smoke

1958 • 101 citations

Prevention of bronchopulmonary dysplasia with vitamin E administration during the acute stages of respiratory distress syndrome

1979 • 97 citations

Inhibition of Superoxide Production and Ca2+ Mobilization in Human Neutrophils by Halothane, Enflurane, and Isoflurane

1986 • 97 citations

Effects of ischemia and oxygen radicals on mucosal albumin clearance in intestine

1982 • 94 citations

Response of isolated rat heart cells to hypoxia, re-oxygenation, and acidosis.

1981 • 91 citations

Effect of diethyldithiocarbamate on oxygen toxicity and lung enzyme activity in immature and adult rats

1978 • 91 citations

ON THE ELECTRON DONATING PROPERTIES OF CARCINOGENS

1960 • 87 citations

Hyperoxia enhances lung and liver nuclear superoxide generation

1984 • 84 citations

Glucose, Insulin, Potassium Protection During the Course of Hypothermic Global Ischemia and Reperfusion

1983 • 83 citations

Cationization of catalase, peroxidase, and superoxide dismutase. Effect of improved intraarticular retention on experimental arthritis in mice.

1985 • 83 citations

Oxygen toxicity in newborn rats: the adverse effects of undernutrition

1982 • 82 citations

Effect of Allopurinol on the Preservation of Ischemic Kidneys Perfused with Plasma or Plasma Substitutes

1974 • 79 citations

Presence of lipid hydroperoxide in human plasma.

1985 • 79 citations

Superoxide and inflammation: a mechanism for the anti-inflammatory activity of superoxide dismutase.

1980 • 72 citations

Role of Free Radical Scavenger in Protection of Spinal Cord during Ischemia

1986 • 72 citations

Human Neutrophil Elastase Does not Bind to Alpha₁-Protease Inhibitor that Has Been Exposed to Activated Human Neutrophils

1983 • 71 citations

The free radical formed during the hydroperoxide-mediated deactivation of ram seminal vesicles is hemoprotein-derived.

1982 • 68 citations

Oxygen-induced lung microvascular injury in neutropenic rabbits and lambs

1985 • 64 citations

Radiobiology for the Radiologist

1974 • 64 citations

Lipid Peroxidation and Acute Myocardial Ischemia

1983 • 63 citations

Effect of stimulated neutrophils from the synovial fluid of patients with rheumatoid arthritis on lymphocytes?A possible role of increased oxygen radicals generated by the neutrophils

1983 • 62 citations

INTRASYNOVIAL ORGOTEIN THERAPY IN RHEUMATOID ARTHRITIS

1981 • 62 citations

Effects of the Antioxidant Butylated Hydroxytoluene (BHT) on Mortality in BALB/c Mice

1979 • 60 citations

Macrophage Effector Function in Pulmonary Oxygen Toxicity: Hyperoxia Damages and Stimulates Alveolar Macrophages to Make and Release Chemotaxins for Polymorphonuclear Leukocytes

1984 • 59 citations

Life Extension

1985 • 59 citations

Free Radicals of Benzo(a)pyrene and Derivatives

1985 • 57 citations

The inactivation of α-1-proteinase inhibitor by gas-phase cigarette smoke: Protection by antioxidants and reducing species

1986 • 56 citations

Contracture of isolated rat heart cells on anaerobic to aerobic transition

1982 • 56 citations

Food constituents as a source of mutagens, carcinogens, and anticarcinogens.

1986 • 54 citations

Mechanism by which Cigarette Smoke Attracts Polymorphonuclear Leukocytes to Lung

1980 • 53 citations

Vitamin E in Kitten Oxygen-Induced Retinopathy

1979 • 53 citations

Free Radical Scavengers and Myocardial Preservation during Transplantation

1986 • 52 citations

The Uncertain Role of the Neutrophil in Increased Permeability Pulmonary Edema

1985 • 52 citations

Failure of desferrioxamine to modify the toxicity of paraquat in rats

1985 • 51 citations

Significance of increased blood uric acid following extensive hemorrhage

1968 • 51 citations

Mortality among health-conscious elderly Californians.

1982 • 51 citations

Potential clinical applications for high-dose nutritional antioxidants

1984 • 50 citations

Free oxygen radicals in cerebral vascular responses.

1983 • 49 citations

Neutrophil Function in a Rat Model of Endotoxin-Induced Lung Injury

1987 • 47 citations

Drug Trial of Superoxide Dismutase in Duchenne's Muscular Dystrophy

1982 • 46 citations

Oxygen radicals and ischemic tissue injury

1986 • 45 citations

Pathophysiology of free radical—mediated reperfusion injury

1987 • 45 citations

Concentration of iron in synovial membrane, synovial fluid, and serum in rheumatoid arthritis and other joint diseases.

1968 • 44 citations

Systemic complement activation and acute lung injury.

1986 • 44 citations

The pathogenesis of emphysema--twenty years of progress.

1981 • 43 citations

ALLOPURINOL AND HYPOXANTHINE PRETREATMENT OF CANINE KIDNEY DONORS

1974 • 42 citations

Free-radical-mediated DNA binding.

1985 • 42 citations

Pharmacology of free radicals; Recent views on their relation to inflammatory mechanisms

1984 • 40 citations

Therapeutic benefits of oxygen radical scavenger treatments remain unproven

1985 • 40 citations

Oxygen Therapy and Long-term Pulmonary Outcome of Respiratory Distress Syndrome in Newborns

1982 • 38 citations

Effects of dimethylsulfoxide (DMSO) on the oxygen paradox in perfused rat hearts.

1982 • 36 citations

Effect of intra-articular orgotein versus a corticosteroid on rheumatoid arthritis of the knees

1983 • 35 citations

Early detection of oxygen-induced lung injury in conscious rabbits. Reduced in vivo activity of angiotensin converting enzyme and removal of 5-hydroxytryptamine.

1982 • 34 citations

Orgotein--(bovine Cu-Zn superoxide dismutase), an anti-inflammatory protein drug: discovery, toxicology and pharmacology.

1981 • 32 citations

Carbon tetrachloride-induced lipid peroxidation: A spin trapping study

1982 • 32 citations

Trauma Serum Suppresses Superoxide Production by Normal Neutrophils

1986 • 29 citations

Oxygen toxicity: Protection of the lung by bacterial lipopolysaccharide (endotoxin)

1979 • 28 citations

Effect of O2 exposure on pulmonary metabolism of prostaglandin E2.

1978 • 27 citations

Inactivation of human alpha 1-proteinase inhibitor by cigarette smoke: effect of smoke phase and buffer.

1985 • 27 citations

Nitrofurantoin-stimulated oxidant production in pulmonary endothelial cells.

1985 • 27 citations

Vitamin E--Its Significance in Mouse Ageing

1981 • 26 citations

Practical Aspects of Radiation Injury

1953 • 25 citations

Effect of Concentration of Oxygen on Occurrence of Pulmonary Tumors in Strain A Mice

1959 • 25 citations

Effect of oxygen exposure on lung clearance of amines

1978 • 24 citations

Bleomycin cytotoxicity is prevented by superoxide dismutase in vitro

1983 • 23 citations

Role of Photosensitization and Oxygen in Chromosome Stability and “Spontaneous” Malignant Transformation in Culture<xref ref-type="fn" rid="FN2">2</xref>

1979 • 23 citations

Utilization of Liposomes for Correction of the Metabolic and Bactericidal Deficiencies in Chronic Granulomatous Disease

1979 • 20 citations

Mechanism by which Cigarette Smoke Attracts Polymorphonuclear Leukocytes to Lung

1980 • 20 citations

Cellular and subcellular events in retinopathy of oxygen toxicity with a preliminary report on the preventive role of vitamin E and gamma-aminobutyric acid: a study<u>in vitro</u>

1984 • 16 citations

The pathogenic role of superoxide radicals in inflammation: efficacy of exogenous superoxide dismutase.

1981 • 14 citations

Endotoxin reverses the decreased tolerance of rats to greater than 95% O2 after preexposure to lower O2

1981 • 13 citations

Fundamentals of Oncology

1982 • 11 citations

Pathology of Vitamin Abnormality

1977 • 10 citations

Metabolism of bleomycin and bleomycin like compounds

1987 • 10 citations

Poisoned Pot Becomes Burning Issue in High Places

1978 • 9 citations

Reactive Oxygen Species and Drug Therapy for Inflammatory Diseases

1985 • 8 citations

Effect of Antibiotics and Sedatives on Normal Neutrophil Nicotinamide-Adenine Dinucleotide Phosphate—Reduced Oxidase Activity

1986 • 8 citations

The Recrudescent Epidemic of Retrolental Fibroplasia

1986 • 3 citations

Fundamentals of Oncology (second edition)

1982 • 1 citations