Reactive oxygen species, antioxidants, and acquired immunodeficiency syndrome. Sense or speculation?

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid

1989 • 1,769 citations

The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis

1988 • 1,496 citations

The antioxidants of human extracellular fluids

1990 • 1,352 citations

How to Characterize a Biological Antioxidant

1990 • 943 citations

Mitochondrial Myopathy Caused by Long-Term Zidovudine Therapy

1990 • 845 citations

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

1989 • 821 citations

LIPID PEROXIDATION, OXYGEN RADICALS, CELL DAMAGE, AND ANTIOXIDANT THERAPY

1984 • 820 citations

Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome

1988 • 739 citations

SYSTEMIC GLUTATHIONE DEFICIENCY IN SYMPTOM-FREE HIV-SEROPOSITIVE INDIVIDUALS

1989 • 725 citations

Modulation of fibroblast proliferation by oxygen free radicals

1990 • 617 citations

Oxygen Radicals in Influenza-Induced Pathogenesis and Treatment with Pyran Polymer-Conjugated SOD

1989 • 420 citations

Regulation of manganese superoxide dismutase by lipopolysaccharide, interleukin-1, and tumor necrosis factor. Role in the acute inflammatory response.

1990 • 382 citations

Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine.

1990 • 381 citations

Free radicals, reactive oxygen species and human disease: a critical evaluation with special reference to atherosclerosis.

1989 • 380 citations

Free Radicals in Medicine. II. Involvement in Human Disease

1988 • 344 citations

Dependence on O2- generation by xanthine oxidase of pathogenesis of influenza virus infection in mice.

1990 • 336 citations

Safety of oral intake of vitamin E

1988 • 298 citations

Role of reactive oxygen metabolites in experimental glomerular disease

1989 • 276 citations

Dynamic state of glutathione in blood plasma.

1980 • 249 citations

Plasma glutathione in health and in patients with malignant disease.

1985 • 248 citations

Free radical-mediated reperfusion injury: a selective review.

1987 • 218 citations

Chronic Granulomatous Disease

1987 • 204 citations

Cachectin (Tumor Necrosis Factor)

1988 • 170 citations

Oxygen-derived Free Radicals in the Pathogenesis of Parasitic Disease

1986 • 143 citations

Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells.

1990 • 137 citations

Inhibition of HIV progression by dithiocarb

1990 • 126 citations

Bleomycin‐detectable iron in serum from leukaemic patients before and after chemotherapy Therapeutic implications for treatment with oxidant‐generating drugs

1988 • 94 citations

Circadian periodicity of tissue glutathione and its relationship with lipid peroxidation in rats

1984 • 84 citations

Lymphocyte dysfunction after DNA damage by toxic oxygen species. A model of immunodeficiency.

1986 • 81 citations

The generation of oxygen radicals: A positive signal for lymphocyte activation

1988 • 80 citations

Inhibition of murine T-cell responses by anti-oxidants: the targets of lipo-oxygenase pathway inhibitors.

1989 • 63 citations

Free Radicals

1987 • 61 citations

Vitamin E Decreases Superoxide Anion Production by Polymorphonuclear Leukocytes

1988 • 50 citations

Review Article the B Lymphocyte: A Newly Recognized Source of Reactive Oxygen Species with Immunoregulatory Potential

1990 • 47 citations

Nutritional Aspects of AIDS

1990 • 35 citations

α-tocopheryl succinate protects hepatocytes from chemical-induced toxicity under physiological calcium conditions

1989 • 33 citations

Increased therapeutic efficacy of Zidovudine in combination with vitamin E

1989 • 32 citations

Active oxygen in neuromuscular disorders

1988 • 30 citations

Vitamin E--a selective inhibitor of the NADPH oxidoreductase enzyme system in human granulocytes.

1983 • 27 citations

2-Mercaptoethanol and n-acetylcysteine enhance T cell colony formation in AIDS and ARC.

1989 • 26 citations

A pilot study of diethyldithiocarbamate in patients with acquired immune deficiency syndrome (AIDS) and the AIDS-related complex

1989 • 25 citations

Review: Measurement of Human Immunodeficiency Virus Load and Its Relation to Disease Progression

1989 • 25 citations

Inhibition of Early Events in the Human T-Lymphocyte Response to Mitogens and Alloantigens by Hydrogen Peroxide

1987 • 18 citations

Superoxide dismutase activity of T lymphocytes and non‐T lymphocytes

1979 • 18 citations

Oxyradical Species and Their Relationship to Pathophysiology in Pediatric Critical Care Illness

1988 • 13 citations