Invited Commentary:Superoxide, Iron, Vascular Endothelium and Reperfusion Injury

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

Superoxide radicals in feline intestinal ischemia

1981 • 1,213 citations

Superoxide Radical: An Endogenous Toxicant

1983 • 1,176 citations

Ischemic injury in the cat small intestine: Role of superoxide radicals

1982 • 771 citations

Endothelium-derived relaxing factor

1988 • 686 citations

Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine

1979 • 637 citations

Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.

1988 • 610 citations

Extracellular superoxide dismutase in human tissues and human cell lines.

1984 • 424 citations

Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues.

1987 • 350 citations

Oxygen-derived free radicals and postischemic myocardial dysfunction (“stunned myocardium”)

1988 • 349 citations

Free radicals and myocardial ischemia and reperfusion injury.

1987 • 307 citations

The primary localization of free radical generation after anoxia/reoxygenation in isolated endothelial cells.

1987 • 285 citations

Endothelium-derived relaxing factor reduces platelet adhesion to bovine endothelial cells.

1988 • 263 citations

Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and transferrin promoters of hydroxyl-radical generation?

1987 • 253 citations

Heparin-induced release of extracellular superoxide dismutase to human blood plasma

1987 • 222 citations

The Inhibition of Lipid Autoxidation by Human Serum and its Relation to Serum Proteins and α-Tocopherol

1974 • 188 citations

Use of desferrioxamine as a ‘probe’ for iron-dependent formation of hydroxyl radicals

1985 • 188 citations

Effect of hydrogen peroxide on prostaglandin production and cellular integrity in cultured porcine aortic endothelial cells.

1985 • 162 citations

Role of hydrogen peroxide in the neutrophil-mediated release of prostacyclin from cultured endothelial cells.

1984 • 140 citations

The activity of xanthine oxidase in heart of pigs, guinea pigs, rabbits, rats, and humans

1987 • 133 citations

Xanthine oxidase is not a source of free radicals in the ischemic rabbit heart

1987 • 127 citations

Hydrogen peroxide has a role in the aggregation of human platelets

1985 • 121 citations

Protection against Superoxide and Hydrogen Peroxide in Synovial Fluid from Rheumatoid Patients

1981 • 120 citations

Product of extracellular‐superoxide dismutase catalysis

1985 • 107 citations

Superoxide dismutase and catalase reduce infarct size in a porcine myocardial occlusion-reperfusion model

1986 • 91 citations

The endothelial cell as a metabolic and endocrine organ

1987 • 74 citations

Absence of xanthine oxidase or xanthine dehydrogenase in the rabbit myocardium

1986 • 68 citations

Xanthine Oxidase is Not Responsible for Reoxygenation Injury in Isolated-Perfused Rat Heart

1987 • 59 citations

Role of toxic effects of oxygen in reperfusion damage

1988 • 46 citations

A superoxide-activated chemotactic factor and its role in the inflammatory process

1980 • 39 citations

Superoxide dismutase inhibits LTB4-induced leukotaxis

1985 • 26 citations

Hydrogen Peroxide—Mediated Inhibition of T-Cell Response to Mitogens Is a Result of Direct Action on T Cells

1988 • 16 citations

Beta adrenergic receptor mediated inhibition of phosphoinositide turnover in isolated perfused guinea pig hearts

1988 • 1 citations