Protein sorting and vesicular traffic in the Golgi apparatus

Handbook of Physiology.

1960 • 10,428 citations

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

1985 • 4,790 citations

Protein folding in the cell

1992 • 4,138 citations

Intracellular Aspects of the Process of Protein Synthesis

1975 • 3,560 citations

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

Mechanisms of intracellular protein transport

1994 • 2,280 citations

Caveolin, a protein component of caveolae membrane coats

1992 • 2,230 citations

The synaptic vesicle cycle: a cascade of protein–protein interactions

1995 • 2,004 citations

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1993 • 1,893 citations

Brefeldin A: insights into the control of membrane traffic and organelle structure.

1992 • 1,848 citations

Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway

1980 • 1,808 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

ENDOCYTOSIS AND MOLECULAR SORTING

1996 • 1,537 citations

An hsp70-like protein in the ER: Identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein

1986 • 1,457 citations

Lipid sorting in epithelial cells

1988 • 1,354 citations

COPII: A membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum

1994 • 1,294 citations

The Lung: Scientific Foundations

1991 • 1,181 citations

The trans Golgi Network: Sorting at the Exit Site of the Golgi Complex

1986 • 1,175 citations

Protein Sorting by Transport Vesicles

1996 • 1,168 citations

Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments

1990 • 1,150 citations

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1996 • 1,101 citations

STRUCTURE AND FUNCTION OF THE MANNOSE 6-PHOSPHATE/INSULINLIKE GROWTH FACTOR II RECEPTORS

1992 • 1,056 citations

Pathways of Protein Secretion in Eukaryotes

1985 • 1,050 citations

Constitutive and Regulated Secretion of Proteins

1987 • 1,021 citations

Protein Oligomerization in the Endoplasmic Reticulum

1989 • 993 citations

The Golgi apparatus (complex)-(1954-1981)-from artifact to center stage.

1981 • 990 citations

BIOSYNTHETIC PROTEIN TRANSPORT AND SORTING BY THE ENDOPLASMIC RETICULUM AND GOLGI

1987 • 985 citations

Molecular dissection of the secretory pathway

1992 • 985 citations

Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells

1993 • 961 citations

Coat Proteins and Vesicle Budding

1996 • 955 citations

Interaction of Tyrosine-Based Sorting Signals with Clathrin-Associated Proteins

1995 • 955 citations

Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum.

1990 • 918 citations

VIP21/caveolin is a cholesterol-binding protein.

1995 • 892 citations

The mannose 6-phosphate receptor and the biogenesis of lysosomes

1988 • 846 citations

Cholesterol and the Golgi Apparatus

1993 • 819 citations

Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding

1995 • 816 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Control of Protein Exit from the Endoplasmic Reticulum

1989 • 794 citations

Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum

1994 • 793 citations

International cell biology 1976–1977

1978 • 762 citations

Regulated internalization of caveolae.

1994 • 760 citations

Tubular membrane invaginations coated by dynamin rings are induced by GTP-γS in nerve terminals

1995 • 760 citations

Potocytosis: Sequestration and Transport of Small Molecules by Caveolae

1992 • 751 citations

Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein

1992 • 741 citations

Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF

1992 • 736 citations

The Lung: Scientific Foundations

1997 • 731 citations

Phosphoinositides as Regulators in Membrane Traffic

1996 • 717 citations

Clathrin, Adaptors, and Sorting

1990 • 704 citations

The molecular machinery for secretion is conserved from yeast to neurons.

1993 • 658 citations

Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis

1994 • 646 citations

Vesicle fusion from yeast to man

1994 • 635 citations

How N-linked oligosaccharides affect glycoprotein folding in the endoplasmic reticulum.

1994 • 617 citations

Immunocytochemical localization of galactosyltransferase in HeLa cells: codistribution with thiamine pyrophosphatase in trans-Golgi cisternae.

1982 • 617 citations

Progress in Unraveling Pathways of Golgi Traffic

1985 • 615 citations

Sec18p (NSF)-Driven Release of Sec17p (α-SNAP) Can Precede Docking and Fusion of Yeast Vacuoles

1996 • 580 citations

Coatomer Interaction with Di-Lysine Endoplasmic Reticulum Retention Motifs

1994 • 574 citations

Rab9 functions in transport between late endosomes and the trans Golgi network.

1993 • 556 citations

Caveolae and caveolins

1996 • 549 citations

Characterization of Two Alternately Spliced Forms of Phospholipase D1

1997 • 547 citations

SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane.

1991 • 544 citations

VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles.

1992 • 544 citations

The rate of bulk flow from the endoplasmic reticulum to the cell surface

1987 • 542 citations

An essential role for a phospholipid transfer protein in yeast Golgi function

1990 • 534 citations

Calnexin: a membrane-bound chaperone of the endoplasmic reticulum

1994 • 533 citations

'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles

1991 • 524 citations

Cell Membrane Resealing by a Vesicular Mechanism Similar to Neurotransmitter Release

1994 • 522 citations

SIGNAL-MEDIATED SORTING OF MEMBRANE PROTEINS BETWEEN THE ENDOPLASMIC RETICULUM AND THE GOLGI APPARATUS

1996 • 506 citations

A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles

1994 • 501 citations

Diffusional Mobility of Golgi Proteins in Membranes of Living Cells

1996 • 499 citations

Role of auxilin in uncoating clathrin-coated vesicles

1995 • 495 citations

Involvement of GTP-binding “G” proteins in transport through the Golgi stack

1987 • 495 citations

β-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the golgi complex, shows homology to β-adaptin

1991 • 489 citations

Identification, by a monoclonal antibody, of a 53-kD protein associated with a tubulo-vesicular compartment at the cis-side of the Golgi apparatus.

1988 • 488 citations

Synaptotagmin I is a high affinity receptor for clathrin AP-2: Implications for membrane recycling

1994 • 483 citations

The Golgi complex: In vitro veritas?

1992 • 481 citations

Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion

1995 • 476 citations

The granin-(chromogranin/secretogranin) family

1991 • 475 citations

VESICLE-MEDIATED PROTEIN SORTING

1992 • 472 citations

A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains

1996 • 465 citations

Caveolae and sorting in the trans-Golgi network of epithelial cells.

1993 • 461 citations

N-glycans as apical sorting signals in epithelial cells

1995 • 454 citations

Carboxypeptidase E Is a Regulated Secretory Pathway Sorting Receptor: Genetic Obliteration Leads to Endocrine Disorders in Cpefat Mice

1997 • 450 citations

Demonstration of an extensive trans-tubular network continuous with the Golgi apparatus stack that may function in glycosylation

1985 • 448 citations

The glycophospholipid-linked folate receptor internalizes folate without entering the clathrin-coated pit endocytic pathway.

1990 • 444 citations

Evidence that luminal ER proteins are sorted from secreted proteins in a post-ER compartment.

1988 • 434 citations

Mechamisms of cell polarity: sorting and transport in epithelial cells

1994 • 430 citations

Non-coated membrane invaginations are involved in binding and internalization of cholera and tetanus toxins

1982 • 428 citations

Caveolin moves from caveolae to the Golgi apparatus in response to cholesterol oxidation.

1994 • 425 citations

The organization of endoplasmic reticulum export complexes.

1996 • 423 citations

The binding of AP-1 clathrin adaptor particles to Golgi membranes requires ADP-ribosylation factor, a small GTP-binding protein

1993 • 422 citations

Calcium pump of the plasma membrane is localized in caveolae.

1993 • 419 citations

Retrieval of transmembrane proteins to the endoplasmic reticulum.

1993 • 414 citations

Giantin, a novel conserved Golgi membrane protein containing a cytoplasmic domain of at least 350 kDa.

1993 • 413 citations

GTPases: Multifunctional Molecular Switches Regulating Vesicular Traffic

1994 • 411 citations

Sequential coupling between COPII and COPI vesicle coats in endoplasmic reticulum to Golgi transport.

1995 • 407 citations

Raf-1 Kinase Possesses Distinct Binding Domains for Phosphatidylserine and Phosphatidic Acid

1996 • 402 citations

Vesicular stomatitis virus glycoprotein is sorted and concentrated during export from the endoplasmic reticulum

1994 • 392 citations

AP-3: an adaptor-like protein complex with ubiquitous expression

1997 • 389 citations

An investigation of the role of transmembrane domains in Golgi protein retention.

1995 • 384 citations

Biogenesis of the rat hepatocyte plasma membrane in vivo: comparison of the pathways taken by apical and basolateral proteins using subcellular fractionation.

1987 • 383 citations

Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles.

1996 • 380 citations

Rab GTPases in vesicular transport

1993 • 379 citations

A coat subunit of Golgi-derived non-clathrin-coated vesicles with homology to the clathrin-coated vesicle coat protein β-adaptin

1991 • 376 citations

Specific binding sites for albumin restricted to plasmalemmal vesicles of continuous capillary endothelium: receptor-mediated transcytosis.

1986 • 375 citations

Role of GTP Hydrolysis in Fission of Caveolae Directly from Plasma Membranes

1996 • 370 citations

Endothelial Caveolae Have the Molecular Transport Machinery for Vesicle Budding, Docking, and Fusion Including VAMP, NSF, SNAP, Annexins, and GTPases

1995 • 370 citations

Overexpression of wild-type and mutant ARF1 and ARF6: distinct perturbations of nonoverlapping membrane compartments.

1995 • 365 citations

Friends and family: The role of the rab GTPases in vesicular traffic

1993 • 364 citations

Binding of ARF and β-COP to Golgi Membranes: Possible Regulation by a Trimeric G Protein

1991 • 359 citations

Recruitment of coat proteins onto Golgi membranes in intact and permeabilized cells: Effects of brefeldin A and G protein activators

1992 • 358 citations

An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes.

1996 • 357 citations

Small GTP-binding protein associated with Golgi cisternae

1990 • 356 citations

Identification, sequencing and expression of an integral membrane protein of the trans-Golgi network (TGN38)

1990 • 355 citations

Vesicles and cisternae in the trans golgi apparatus of human fibroblasts are acidic compartments

1985 • 350 citations

Mapping the distribution of Golgi enzymes involved in the construction of complex oligosaccharides

1995 • 350 citations

The role of clathrin, adaptors and dynamin in endocytosis

1994 • 343 citations

The absence of Emp24p, a component of ER-derived COPII-coated vesicles, causes a defect in transport of selected proteins to the Golgi.

1995 • 341 citations

Specificity of binding of clathrin adaptors to signals on the mannose-6-phosphate/insulin-like growth factor II receptor.

1989 • 336 citations

β-COP is essential for biosynthetic membrane transport from the endoplasmic reticulum to the Golgi complex in vivo

1993 • 336 citations

Cell type-dependent variations in the subcellular distribution of alpha-mannosidase I and II

1993 • 336 citations

Bimodal Interaction of Coatomer with the p24 Family of Putative Cargo Receptors

1996 • 333 citations

Protein sorting by tyrosine-based signals: adapting to the Ys and wherefores

1997 • 329 citations

The inositol 1,4,5,-trisphosphate receptor in cerebellar Purkinje cells: quantitative immunogold labeling reveals concentration in an ER subcompartment.

1990 • 326 citations

Storage and release of neurotransmitters

1993 • 324 citations

Golgi localization of glycosyltransferases: more questions than answers

1997 • 323 citations

GTPase activity of Rab5 acts as a timer for endocytic membrane fusion

1996 • 322 citations

Semi-intact cells permeable to macromolecules: Use in reconstitution of protein transport from the endoplasmic reticulum to the Golgi complex

1987 • 321 citations

An N-terminal double-arginine motif maintains type II membrane proteins in the endoplasmic reticulum.

1994 • 315 citations

Rab GTPases: master regulators of membrane trafficking

1994 • 315 citations

Distribution of the intermediate elements operating in ER to Golgi transport

1991 • 315 citations

Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components.

1996 • 314 citations

Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae.

1995 • 310 citations

The involvement of calcium in transport of secretory proteins from the endoplasmic reticulum

1990 • 310 citations

Golgi membranes contain an electrogenic H+ pump in parallel to a chloride conductance.

1983 • 310 citations

Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses

1997 • 309 citations

Biochemical dissection of AP-1 recruitment onto Golgi membranes.

1993 • 308 citations

A heterotrimeric G protein, G alpha i-3, on Golgi membranes regulates the secretion of a heparan sulfate proteoglycan in LLC-PK1 epithelial cells.

1991 • 304 citations

Stepwise assembly of functionally active transport vesicles

1993 • 298 citations

Sequences within and adjacent to the transmembrane segment of alpha-2,6-sialyltransferase specify Golgi retention.

1991 • 296 citations

The endoplasmic reticulum as a protein-folding compartment

1992 • 296 citations

The role of n-glycans in the secretory pathway

1995 • 295 citations

Structural Determinants of Interaction of Tyrosine-based Sorting Signals with the Adaptor Medium Chains

1996 • 294 citations

Attachment of terminal N-acetylglucosamine to asparagine-linked oligosaccharides occurs in central cisternae of the golgi stack

1985 • 291 citations

Cytoplasmic coat proteins involved in endosome function

1995 • 290 citations

Cell-free protein sorting to the regulated and constitutive secretory pathways

1990 • 289 citations

The small GTP-binding protein rab4 is associated with early endosomes.

1991 • 286 citations

The dynamins: Redundant or distinct functions for an expanding family of related GTPases?

1997 • 286 citations

The emergence of clathrin-independent pinocytic pathways

1995 • 282 citations

Membrane flow and interconversions among endomembranes

1979 • 279 citations

COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeast

1995 • 278 citations

Intracellular trafficking of lysosomal membrane proteins

1996 • 277 citations

Rab proteins and the road maps for intracellular transport

1993 • 276 citations

The trans-most cisternae of the Golgi complex: A compartment for sorting of secretory and plasma membrane proteins

1987 • 275 citations

Distinct transport vesicles mediate the delivery of plasma membrane proteins to the apical and basolateral domains of MDCK cells.

1990 • 273 citations

Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes.

1996 • 272 citations

Nucleotide exchange on ARF mediated by yeast Geal protein

1996 • 271 citations

Evidence for extensive subcellular organization of asparagine-linked oligosaccharide processing and lysosomal enzyme phosphorylation.

1983 • 270 citations

Fluoride is not an activator of the smaller (20-25 kDa) GTP-binding proteins

1991 • 267 citations

Signal-mediated retrieval of a membrane protein from the Golgi to the ER in yeast.

1994 • 265 citations

Signal transduction and membrane traffic: The PITP/phosphoinositide connection

1995 • 261 citations

The Differentiating Intestinal Epithelial Cell: Establishment and Maintenance of Functions Through Interactions Between Cellular Structures

1992 • 260 citations

ARF: a key regulatory switch in membrane traffic and organelle structure

1994 • 258 citations

Localization of TGN38 to the trans-Golgi network: involvement of a cytoplasmic tyrosine-containing sequence.

1993 • 258 citations

Tyrosine Sulfation and the Secretory Pathway

1988 • 257 citations

Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5.

1995 • 255 citations

Identification of an intermediate compartment involved in protein transport from endoplasmic reticulum to Golgi apparatus.

1990 • 252 citations

The small GTP-binding protein rab6 functions in intra-Golgi transport.

1994 • 251 citations

Identification of the Binding Site for Acidic Phospholipids on the PH Domain of Dynamin: Implications for Stimulation of GTPase Activity

1996 • 250 citations

Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

1982 • 248 citations

A MOLECULAR DESCRIPTION OF SYNAPTIC VESICLE MEMBRANE TRAFFICKING

1994 • 248 citations

Glycosphingolipid-enriched, detergent-insoluble complexes in protein sorting in epithelial cells

1993 • 246 citations

Density of newly synthesized plasma membrane proteins in intracellular membranes II. Biochemical studies.

1984 • 246 citations

Retention and retrieval in the endoplasmic reticulum and the Golgi apparatus

1994 • 243 citations

Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent steps.

1995 • 243 citations

Membrane Dynamics at the Endoplasmic Reticulum–Golgi Interface

1997 • 243 citations

A novel adaptor-related protein complex.

1996 • 241 citations

Different requirements for NSF, SNAP, and Rab proteins in apical and basolateral transport in MDCK cells

1995 • 241 citations

Different biosynthetic transport routes to the plasma membrane in BHK and CHO cells.

1996 • 238 citations

The membrane spanning domain of beta-1,4-galactosyltransferase specifies trans Golgi localization.

1991 • 237 citations

VIP36, a novel component of glycolipid rafts and exocytic carrier vesicles in epithelial cells.

1994 • 232 citations

An integral membrane component of coatomer-coated transport vesicles defines a family of proteins involved in budding.

1995 • 229 citations

Microtubules, membrane traffic, and cell organization

1990 • 229 citations

Molecular Mechanisms in Synaptic Vesicle Endocytosis and Recycling

1996 • 229 citations

HVEM tomography of the trans-Golgi network: structural insights and identification of a lace-like vesicle coat.

1994 • 229 citations

Endosome dynamics regulated by a Rho protein

1996 • 225 citations

The endoplasmic reticulum—Golgi intermediate compartment

1992 • 224 citations

Kin recognition

1993 • 223 citations

Interactions between Newly Synthesized Glycoproteins, Calnexin and a Network of Resident Chaperones in the Endoplasmic Reticulum

1997 • 218 citations

Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol

1993 • 218 citations

Membrane trafficking in the presynaptic nerve terminal

1995 • 217 citations

Overlapping distribution of two glycosyltransferases in the Golgi apparatus of HeLa cells.

1993 • 217 citations

A major transmembrane protein of Golgi-derived COPI-coated vesicles involved in coatomer binding.

1996 • 215 citations

Erv25p, a Component of COPII-coated Vesicles, Forms a Complex with Emp24p That Is Required for Efficient Endoplasmic Reticulum to Golgi Transport

1996 • 210 citations

TRANSPORT VESICLE DOCKING: SNAREs and Associates

1996 • 207 citations

Role of heterotrimeric G proteins in membrane traffic.

1992 • 206 citations

A His-Leu-Leu sequence near the carboxyl terminus of the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor is necessary for the lysosomal enzyme sorting function.

1992 • 205 citations

Compartmentation of asparagine-linked oligosaccharide processing in the Golgi apparatus.

1983 • 203 citations

Assembly of the ER to Golgi SNARE complex requires Uso1p.

1996 • 203 citations

SNARE-Mediated Retrograde Traffic from the Golgi Complex to the Endoplasmic Reticulum

1996 • 201 citations

The Two Mannose 6-Phosphate Receptors Transport Distinct Complements of Lysosomal Proteins

1995 • 201 citations

A specific transmembrane domain of a coronavirus E1 glycoprotein is required for its retention in the Golgi region.

1987 • 199 citations

The Role of GTP-Binding Proteins in Transport Along the Exocytic Pathway

1993 • 199 citations

Localization of the Lys, Asp, Glu, Leu tetrapeptide receptor to the Golgi complex and the intermediate compartment in mammalian cells.

1994 • 197 citations

Mammalian Sec23p homologue is restricted to the endoplasmic reticulum transitional cytoplasm.

1991 • 196 citations

Recycling of proteins between the endoplasmic reticulum and Golgi complex

1991 • 194 citations

Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A.

1995 • 193 citations

Regulation of apical transport in epithelial cells by a Gsclass of heterotrimeric G protein

1993 • 188 citations

Antibodies to rat pancreas Golgi subfractions: identification of a 58-kD cis-Golgi protein.

1987 • 186 citations

Receptor-Mediated Protein Sorting to the Vacuole in Yeast: Roles for a Protein Kinase, a Lipid Kinase and GTP-Binding Proteins

1995 • 184 citations

Golgi and vacuolar membrane proteins reach the vacuole in vps1 mutant yeast cells via the plasma membrane.

1995 • 183 citations

Expression and polarized targeting of a rab3 isoform in epithelial cells.

1994 • 179 citations

ERGIC-53 is a functional mannose-selective and calcium-dependent human homologue of leguminous lectins.

1996 • 177 citations

Differential subcompartmentation of terminal glycosylation in the Golgi apparatus of intestinal absorptive and goblet cells.

1986 • 172 citations

Newly Synthesized Transferrin Receptors Can Be Detected in the Endosome before They Appear on the Cell Surface

1995 • 170 citations

The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/lysosomal system.

1994 • 169 citations

A phosphatidylinositol transfer protein controls the phosphatidylcholine content of yeast Golgi membranes

1994 • 169 citations

ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif.

1993 • 167 citations

Differentiated microdomains on the luminal surface of capillary endothelium: distribution of lectin receptors.

1982 • 166 citations

VIP21/caveolin, glycosphingolipid clusters and the sorting of glycosylphosphatidylinositol-anchored proteins in epithelial cells.

1994 • 166 citations

Proteolytic Processing of Pro-ACTH/Endorphin Begins in the Golgi Complex of Pituitary Corticotropes and AtT-20 Cells

1989 • 165 citations

Identification of the Sorting Signal Motif within Pro-opiomelanocortin for the Regulated Secretory Pathway

1995 • 165 citations

Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs

1995 • 163 citations

Localization of Sed5, a putative vesicle targeting molecule, to the cis-Golgi network involves both its transmembrane and cytoplasmic domains.

1994 • 162 citations

Ultrastructural localization of the mannose 6-phosphate receptor in rat liver.

1984 • 162 citations

A Functional Phosphatidylinositol 3,4,5-Trisphosphate/Phosphoinositide Binding Domain in the Clathrin Adaptor AP-2 α Subunit. IMPLICATIONS FOR THE ENDOCYTIC PATHWAY

1996 • 162 citations

Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain

1996 • 158 citations

Sorting and retrieval between the endoplasmic reticulum and Golgi apparatus

1995 • 157 citations

In vivo phosphorylation of adaptors regulates their interaction with clathrin.

1996 • 157 citations

Intracellular Ca2+ stores in chicken Purkinje neurons: differential distribution of the low affinity-high capacity Ca2+ binding protein, calsequestrin, of Ca2+ ATPase and of the ER lumenal protein, Bip.

1991 • 156 citations

Secretory Granule Content Proteins and the Luminal Domains of Granule Membrane Proteins Aggregate in Vitro at Mildly Acidic pH

1996 • 155 citations

Molecular cloning, characterization, subcellular localization and dynamics of p23, the mammalian KDEL receptor.

1993 • 154 citations

Oligomerization of a membrane protein correlates with its retention in the Golgi complex

1993 • 154 citations

Retention and retrieval: both mechanisms cooperate to maintain calreticulin in the endoplasmic reticulum

1994 • 154 citations

Endoplasmic reticulum: a dynamic patchwork of specialized subregions.

1992 • 154 citations

Syntaxin 5 regulates endoplasmic reticulum to Golgi transport.

1994 • 153 citations

Rab1 and Ca2+ are required for the fusion of carrier vesicles mediating endoplasmic reticulum to Golgi transport.

1994 • 151 citations

Annexin XIIIb: a novel epithelial specific annexin is implicated in vesicular traffic to the apical plasma membrane.

1995 • 150 citations

The Saccharomyces cerevisiae phosphatidylinositol-transfer protein effects a ligand-dependent inhibition of choline-phosphate cytidylyltransferase activity.

1995 • 150 citations

The signal for Golgi retention of bovine beta 1,4-galactosyltransferase is in the transmembrane domain.

1992 • 148 citations

En bloc incorporation of coatomer subunits during the assembly of COP- coated vesicles [published erratum appears in J Cell Biol 1994 Jul;126(2):589]

1994 • 146 citations

Protein Transfer and Organelle Biogenesis

1988 • 146 citations

The small gtp-binding protein rab6p is distributed from medial golgi to the Trans-golgi network as determined by a confocal microscopic approach

1992 • 138 citations

Role of the matrixin MMP-2 in multicellular organization of adipocytes cultured in basement membrane components

1997 • 138 citations

Delta- and zeta-COP, two coatomer subunits homologous to clathrin-associated proteins, are involved in ER retrieval.

1996 • 138 citations

The small GTPases Rac and Rho as regulators of secretion in mast cells

1995 • 137 citations

Subcellular localization of the UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-mediated O-glycosylation reaction in the submaxillary gland.

1994 • 136 citations

The role of the membrane-spanning domain and stalk region of N-acetylglucosaminyltransferase I in retention, kin recognition and structural maintenance of the Golgi apparatus in HeLa cells

1996 • 135 citations

Differential distribution of alpha subunits and beta gamma subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreas.

1996 • 134 citations

A cytosolic complex of p62 and rab6 associates with TGN38/41 and is involved in budding of exocytic vesicles from the trans-Golgi network

1993 • 133 citations

Beta-COP is essential for transport of protein from the endoplasmic reticulum to the Golgi in vitro

1993 • 133 citations

Mechanism of clathrin basket dissociation: separate functions of protein domains of the DnaJ homologue auxilin.

1996 • 131 citations

Ca2+ triggers massive exocytosis in Chinese hamster ovary cells.

1996 • 129 citations

Perforated MDCK cells support intracellular transport.

1987 • 129 citations

Misfolded major histocompatibility complex class I molecules accumulate in an expanded ER-Golgi intermediate compartment.

1995 • 129 citations

Pathways of protein sorting and membrane traffic between the rough endoplasmic reticulum and the Golgi complex

1992 • 127 citations

Coats and vesicle budding

1997 • 127 citations

The 17-residue transmembrane domain of beta-galactoside alpha 2,6-sialyltransferase is sufficient for Golgi retention

1992 • 126 citations

Neither type of mannose 6-phosphate receptor is sufficient for targeting of lysosomal enzymes along intracellular routes.

1996 • 123 citations

SNAREs and the specificity of transport vesicle targeting

1995 • 123 citations

The Mammalian Homolog of Yeast Sec13p Is Enriched in the Intermediate Compartment and Is Essential for Protein Transport from the Endoplasmic Reticulum to the Golgi Apparatus

1997 • 122 citations

Purification and characterization of tyrosylprotein sulfotransferase.

1990 • 121 citations

A soluble secretory protein is first concentrated in the endoplasmic reticulum before transfer to the Golgi apparatus.

1993 • 121 citations

Mannose 6-Phosphate Receptors and ADP-ribosylation Factors Cooperate for High Affinity Interaction of the AP-1 Golgi Assembly Proteins with Membranes

1996 • 121 citations

5'nucleotidase is sorted to the apical domain of hepatocytes via an indirect route [published erratum appears in J Cell Biol 1993 Nov;123(3):following 767]

1992 • 121 citations

Synthesis and secretion of collagen by cells of connective tissue, bone, and dentin

1989 • 121 citations

Targeting of protein ERGIC-53 to the ER/ERGIC/cis-Golgi recycling pathway.

1995 • 120 citations

Identification of a 200-kD, brefeldin-sensitive protein on Golgi membranes

1992 • 120 citations

The E1 glycoprotein of an avian coronavirus is targeted to the cis Golgi complex.

1990 • 118 citations

Trimeric G‐proteins of the trans‐Golgi network are involved in the formation of constitutive secretory vesicles and immature secretory granules

1991 • 117 citations

The isolated ER-Golgi intermediate compartment exhibits properties that are different from ER and cis-Golgi.

1991 • 116 citations

Coated pits and coated vesicles — sorting it all out

1993 • 115 citations

About turn for the COPs?

1994 • 114 citations

COPs Regulating Membrane Traffic

1995 • 114 citations

Mannose 6-Phosphate Receptors Regulate the Formation of Clathrin-coated Vesicles in the TGN

1997 • 113 citations

Sequence and overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golgi membrane protein.

1997 • 112 citations

Prohormone processing in the trans-Golgi network: endoproteolytic cleavage of prosomatostatin and formation of nascent secretory vesicles in permeabilized cells

1993 • 112 citations

Involvement of the GTP binding protein Rho in constitutive endocytosis in Xenopus laevis oocytes.

1995 • 110 citations

Targeting and retention of Golgi membrane proteins

1993 • 110 citations

Density of newly synthesized plasma membrane proteins in intracellular membranes. I. Stereological studies.

1984 • 108 citations

Role of Phospholipase D Activation in Nervous System Physiology and Pathophysiology

1995 • 107 citations

Cloning and subcellular localization of novel rab proteins reveals polarized and cell type-specific expression

1994 • 106 citations

In Vitro Assembly and Disassembly of Coatomer

1995 • 106 citations

Human SEC13Rp functions in yeast and is located on transport vesicles budding from the endoplasmic reticulum.

1995 • 105 citations

Different Domains of the AP-1 Adaptor Complex Are Required for Golgi Membrane Binding and Clathrin Recruitment

1995 • 104 citations

Effects of acid phospholipids on nucleotide exchange properties of ADP-ribosylation factor 1. Evidence for specific interaction with phosphatidylinositol 4,5-bisphosphate.

1994 • 104 citations

Transcytosis in the continuous endothelium of the myocardial microvasculature is inhibited by N-ethylmaleimide.

1994 • 102 citations

Anterograde and retrograde traffic between the rough endoplasmic reticulum and the Golgi complex.

1995 • 102 citations

Two integral membrane proteins located in the cis-middle and trans-part of the Golgi system acquire sialylated N-linked carbohydrates and display different turnovers and sensitivity to cAMP-dependent phosphorylation.

1987 • 100 citations

The rubella virus E1 glycoprotein is arrested in a novel post-ER, pre-Golgi compartment.

1992 • 100 citations

Biosynthetic transport of the asialoglycoprotein receptor H1 to the cell surface occurs via endosomes.

1995 • 98 citations

Intracellular trafficking of proteins

1991 • 97 citations

Plasmalemmal vesicles function as transcytotic carriers for small proteins in the continuous endothelium

1997 • 96 citations

Secretory granule and synaptic vesicle formation

1991 • 95 citations

Membrane and secretory proteins are transported from the Golgi complex to the sinusoidal plasmalemma of hepatocytes by distinct vesicular carriers.

1994 • 95 citations

Nonclathrin coat protein gamma, a subunit of coatomer, binds to the cytoplasmic dilysine motif of membrane proteins of the early secretory pathway.

1996 • 94 citations

Trimeric G proteins and vesicle formation

1992 • 94 citations

Clathrin-coated pits contain an integral membrane protein that binds the AP-2 subunit with high affinity.

1990 • 93 citations

The transmembrane and flanking sequences of beta 1,2-N-acetylglucosaminyltransferase I specify medial-Golgi localization.

1992 • 92 citations

Golgi coatomer binds, and forms K(+)-selective channels gated by, inositol polyphosphates.

1994 • 90 citations

Role of heterotrimeric GTP binding proteins in vesicular protein transport: indications for both classical and alternative G protein cycles

1995 • 90 citations

The KKXX signal mediates retrieval of membrane proteins from the Golgi to the ER in yeast.

1994 • 89 citations

A biosynthetic regulated secretory pathway in constitutive secretory cells.

1996 • 89 citations

Molecular Cloning and Expression of a 58-kDa cis-Golgi and Intermediate Compartment Protein

1996 • 89 citations

Traffic COPs and the formation of vesicle coats

1996 • 88 citations

Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex.

1996 • 87 citations

SED4 encodes a yeast endoplasmic reticulum protein that binds Sec16p and participates in vesicle formation.

1995 • 86 citations

The production of post-Golgi vesicles requires a protein kinase C-like molecule, but not its phosphorylating activity.

1996 • 85 citations

Exocytic transport vesicles generated in vitro from the trans-Golgi network carry secretory and plasma membrane proteins.

1990 • 85 citations

The transmembrane domain of N-glucosaminyltransferase I contains a Golgi retention signal.

1992 • 84 citations

Principles of selective transport: coat complexes hold the key

1996 • 84 citations

Cellular variations in heterotrimeric G protein localization and expression in rat pituitary.

1994 • 83 citations

Intracellular trafficking of proteins

1992 • 82 citations

Concentration of intracellular hepatic apolipoprotein E in Golgi apparatus saccular distensions and endosomes.

1994 • 82 citations

Comparison of components of the testis interstitium with testosterone secretion in hamster, rat, and guinea pig testes perfused in vitro

1988 • 81 citations

Transport of casein submicelles and formation of secretion granules in the golgi apparatus of epithelial cells of the lactating mammary gland of the rat

1993 • 80 citations

Localization of O-glycan initiation, sphingomyelin synthesis, and glucosylceramide synthesis in Vero cells with respect to the endoplasmic reticulum-Golgi intermediate compartment.

1994 • 79 citations

Receptor signalling and the regulation of endocytic membrane transport

1996 • 76 citations

Rab-GDI presents functional Rab9 to the intracellular transport machinery and contributes selectivity to Rab9 membrane recruitment.

1994 • 74 citations

The secretory pathway: mechanisms of protein sorting and transport

1996 • 73 citations

The role of coat proteins in the biosynthesis of secretory proteins

1995 • 73 citations

Coated vesicles: a diversity of form and function

1995 • 71 citations

Vacuolar biogenesis in yeast: Sorting out the sorting proteins

1995 • 69 citations

Distinct coated vesicles labeled for p200 bud from trans-Golgi network membranes.

1995 • 68 citations

Formation of nascent secretory vesicles from the trans-Golgi network of endocrine cells is inhibited by tyrosine kinase and phosphatase inhibitors.

1996 • 68 citations

Phospholipid signalling: Rho is only ARF the story

1996 • 66 citations

The η Isoform of Protein Kinase C Mediates Transcriptional Activation of the Human Transglutaminase 1 Gene

1996 • 66 citations

Involvement of β-COP in membrane traffic through the Golgi complex

1991 • 64 citations

Gs regulation of endosome fusion suggests a role for signal transduction pathways in endocytosis.

1994 • 61 citations

Precursors of chondroitin sulfate proteoglycan are segregated within a subcompartment of the chondrocyte endoplasmic reticulum.

1989 • 61 citations

The in Vitro Generation of Post-Golgi Vesicles Carrying Viral Envelope Glycoproteins Requires an ARF-like GTP-binding Protein and a Protein Kinase C Associated with the Golgi Apparatus

1996 • 59 citations

Antibodies to Clathrin Inhibit Endocytosis But Not Recycling to the Trans Golgi Network in Vitro

1990 • 58 citations

High resolution analysis of the secretory pathway in mammotrophs of the rat anterior pituitary.

1981 • 58 citations

Transport of lipids to the plasma membrane in animal cells

1993 • 57 citations

Potential roles of heterotrimeric G proteins of the endomembrane system

1996 • 57 citations

Molecular genetic analyses of a 376-kilodalton Golgi complex membrane protein (giantin)

1994 • 57 citations

Phospholipid metabolism and membrane dynamics

1996 • 57 citations

Enzymes associated with glycosylation

1992 • 56 citations

TGN38/41: a molecule on the move

1993 • 56 citations

Protein trafficking along the exocytotic pathway

1993 • 55 citations

Heterotrimeric G Proteins Interact with the Small GTPase ARF

1995 • 55 citations

The regulation of endocytosis: identifying dynamin's binding partners

1995 • 54 citations

Purification and Characterization of the Human KDEL Receptor

1996 • 52 citations

Coat proteins in intracellular membrane transport

1994 • 51 citations

Biosynthesis and intracellular sorting of growth hormone-viral envelope glycoprotein hybrids.

1985 • 50 citations

Prosomatostatin is processed in the Golgi apparatus of rat neural cells

1991 • 49 citations

Rab1a and Multiple Other Rab Proteins Are Associated with the Transcytotic Pathway in Rat Liver

1996 • 49 citations

The Reorganization of the Golgi Complex in Anoxic Pancreatic Acinar Cells

1986 • 48 citations

Isolation and characterization of a class II α-mannosidase cDNA from lepidopteran insect cells

1997 • 46 citations

Epithelial cell polarity: new perspectives.

1995 • 46 citations

Epoxide hydrolase is a marker for the smooth endoplasmic reticulum in rat liver.

1985 • 43 citations

Budding Vesicles in Living Cells

1996 • 42 citations

Clathrin-associated adaptor proteins — putting it all together

1997 • 42 citations

Kinetic and spatial interrelationships between ganglioside glycosyltransferases and O-acetyltransferase(s) in human melanoma cells

1993 • 40 citations

And still they are moving… Dynamic properties of caveolae

1996 • 40 citations

A Novel Mutagenesis Strategy Identifies Distantly Spaced Amino Acid Sequences That Are Required for the Phosphorylation of Both the Oligosaccharides of Procathepsin D by N-Acetylglucosamine 1-Phosphotransferase

1995 • 39 citations

Golgi apparatus and slime secretion in plants: the early implications and recent models of membrane traffic

1993 • 38 citations

Biochemical Heterogeneity and Phosphorylation of Coatomer Subunits

1996 • 38 citations

A monomeric protein in the Golgi membrane catalyzes both N-deacetylation and N-sulfation of heparan sulfate.

1994 • 36 citations

Expression of mutant ELH prohormones in AtT-20 cells: the relationship between prohormone processing and sorting.

1993 • 33 citations

Binding of the cytosolic p200 protein to Golgi membranes is regulated by heterotrimeric G proteins

1993 • 33 citations

Low molecular weight GTP-binding proteins associated with zymogen granule membranes from rat pancreas

1991 • 31 citations

Biosynthesis of oligosaccharides in intact Golgi preparations from rat liver. Analysis of N-linked glycans labeled by UDP-[6-3H]N-acetylglucosamine

1993 • 31 citations

Golgi Apparatus Function in Membrane Flow and Differentiation: Origin of Plasma Membrane from Endoplasmic Reticulum

1971 • 30 citations

SEC22 and SLY2 are identical.

1992 • 29 citations

The small G‐protein ARF1_GDP binds to the G_tβγ subunit of transducin, but not to G_tα_GDP‐G_tβγ

1995 • 29 citations

Regulated secretion

1990 • 28 citations

Biosynthesis of oligosaccharides in intact Golgi preparations from rat liver. Analysis of N-linked glycans labeled by UDP-[6-3H]galactose, CMP-[9-3H]N-acetylneuraminic acid, and [acetyl-3H]acetyl-coenzyme A

1993 • 27 citations

Transferrin receptors and cation-independent mannose-6-phosphate receptors deliver their ligands to two distinct subpopulations of multivesicular endosomes.

1989 • 25 citations

Recycling of the endoplasmic reticulum/Golgi intermediate compartment protein ERGIC-53 in the secretory pathway

1995 • 23 citations

Regulation of vesicular transport by GTP-binding proteins

1995 • 23 citations

SNAREs Involved in Traffic through the Golgi Complex

1995 • 22 citations

Morphological Analysis of the Transfer of VSV ts-045 G Glycoprotein from the Endoplasmic Reticulum to the Intermediate Compartment in Vero Cells

1996 • 18 citations

Interleaflet clear space is reduced in the membrane of COP I and COP II-coated buds/vesicles.

1996 • 18 citations

Control of Exocytosis in Yeast

1995 • 18 citations

Stereological and functional investigations on isolated adrenocortical cells: Zona fasciculata/reticularis cells of chronically ACTH-treated rats

1989 • 16 citations

Novel GTP‐binding proteins in plasma membranes and zymogen granule membranes from rat pancreas and in pancreatic AR 4‐2J cell membranes

1990 • 14 citations

High- and Small-Molecular-Weight GTP-Binding Proteins in Zymogen Granule Membranes of Rat Pancreatic Acinar Cells

1992 • 14 citations

Molecules and Vesicle Coats Involved in the Budding of Exocytotic Vesicles from the trans-Golgi Network

1995 • 13 citations

Induction of cytochrome P450 by phenobarbital in rat liver visualized by monoclonal antibody immunoelectron microscopy in situ.

1990 • 12 citations

Protein Kinesis: The Dynamics of Protein Trafficking and Stability.

1997 • 12 citations

Biogenesis of Secretory Vesicles

1988 • 8 citations

Insights into the Molecular Mechanisms of Synaptic Vesicle Docking and Fusion

1995 • 6 citations

Regulation of Post-Golgi Vesicle Production in an In Vitro System

1995 • 3 citations

ER-Golgi membrane traffic and protein targeting

1996 • 2 citations

Protein sorting during endocytosis

1996 • 2 citations

Additions and Corrections

1989 • 1 citations

Deleted Work

1955 • 0 citations