Formation of nascent secretory vesicles from the trans-Golgi network of endocrine cells is inhibited by tyrosine kinase and phosphatase inhibitors.

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The molecular machinery for secretion is conserved from yeast to neurons.

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Vesicle fusion from yeast to man

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[41] Use of vanadate as protein-phosphotyrosine phosphatase inhibitor

1991 • 583 citations

Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.

1994 • 533 citations

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1993 • 532 citations

ATP-dependent inositide phosphorylation required for Ca2+-activated secretion

1995 • 508 citations

Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane.

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The insulinomimetic agents H2O2 and vanadate stimulate protein tyrosine phosphorylation in intact cells.

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GTPases: Multifunctional Molecular Switches Regulating Vesicular Traffic

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Pervanadate [peroxide(s) of vanadate] mimics insulin action in rat adipocytes via activation of the insulin receptor tyrosine kinase

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Rab GTPases: master regulators of membrane trafficking

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Src family protein tyrosine kinases and cellular signal transduction pathways

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1992 • 206 citations

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1995 • 193 citations

Regulation of apical transport in epithelial cells by a Gsclass of heterotrimeric G protein

1993 • 188 citations

A role for phosphatidylinositol transfer protein in secretory vesicle formation

1995 • 186 citations

Multiple trimeric G-proteins on the trans-Golgi network exert stimulatory and inhibitory effects on secretory vesicle formation.

1992 • 184 citations

Receptor-Mediated Protein Sorting to the Vacuole in Yeast: Roles for a Protein Kinase, a Lipid Kinase and GTP-Binding Proteins

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Protein tyrosine phosphatases in signaling

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Regulated Formation of Golgi Secretory Vesicles Containing Alzheimer β-Amyloid Precursor Protein

1995 • 165 citations

Recruitment of epidermal growth factor receptors into coated pits requires their activated tyrosine kinase.

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1995 • 144 citations

A cytosolic complex of p62 and rab6 associates with TGN38/41 and is involved in budding of exocytic vesicles from the trans-Golgi network

1993 • 133 citations

Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide)

1992 • 121 citations

Identification of a 200-kD, brefeldin-sensitive protein on Golgi membranes

1992 • 120 citations

Prohormone processing in the trans-Golgi network: endoproteolytic cleavage of prosomatostatin and formation of nascent secretory vesicles in permeabilized cells

1993 • 112 citations

Mechanism of vanadate-induced activation of tyrosine phosphorylation and of the respiratory burst in HL60 cells. Role of reduced oxygen metabolites

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Ras Mediates the Activation of Phospholipase D by v-Src

1995 • 87 citations

Tyrosine Phosphorylation-dependent Stimulation of Amyloid Precursor Protein Secretion by the m3 Muscarinic Acetylcholine Receptor

1995 • 80 citations

Activators of protein kinase A stimulate apical but not basolateral transport in epithelial Madin-Darby canine kidney cells.

1994 • 77 citations

ADP-ribosylation Factor-1 Stimulates Formation of Nascent Secretory Vesicles from the trans-Golgi Network of Endocrine Cells

1996 • 68 citations

Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein.

1995 • 68 citations

Endocytosis of activated receptors and clathrin-coated pit formation: deciphering the chicken or egg relationship.

1996 • 65 citations

The amino terminus of ADP-ribosylation factor (ARF) 1 is essential for interaction with Gs and ARF GTPase-activating protein.

1994 • 57 citations

Heterotrimeric G Proteins Interact with the Small GTPase ARF

1995 • 55 citations

Interaction between G Proteins and Tyrosine Kinases upon T Cell Receptor·CD3-mediated Signaling

1995 • 55 citations

Prosomatostatin Processing in Permeabilized Cells

1996 • 54 citations

An elevation of cytosolic protein phosphorylation modulates trimeric G-protein regulation of secretory vesicle formation from the trans-Golgi network.

1994 • 52 citations

Protein tyrosine phosphatase stimulates Ca(2+)-dependent amylase secretion from pancreatic acini.

1991 • 52 citations

Somatostatin discriminates between the intracellular pathways of secretory and membrane proteins.

1984 • 50 citations

Retrovirus-mediated expression of preprosomatostatin: posttranslational processing, intracellular storage, and secretion in GH3 pituitary cells.

1988 • 47 citations

The roles of multiple pathways in regulating bombesin-stimulated phospholipase D activity in Swiss 3T3 fibroblasts

1995 • 24 citations

Prosomatostatin processing in pituitary GH3 cells. Identification and secretion of the intact propeptide.

1994 • 8 citations

A group of integral membrane proteins of the rat liver Golgi contains a conserved protein of 100 kDa

1994 • 7 citations

Formation of secretory vesicles in permeabilized cells: a salt extract from yeast membranes promotes budding of nascent secretory vesicles from the trans-Golgi network of endocrine cells

1996 • 6 citations