Physiological functions of endosomal proteolysis

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

1985 • 4,790 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS

1986 • 1,977 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2K ^b

1992 • 864 citations

The mannose 6-phosphate receptor and the biogenesis of lysosomes

1988 • 846 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Assembly, Transport, and Function of MHC Class II Molecules

1994 • 791 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

Lysosomal Storage Diseases

2012 • 643 citations

Transport and Storage of Vitamin A

1990 • 618 citations

Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.

1982 • 576 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

Trafficking of lysosomal enzymes ¹

1987 • 497 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

Low temperature selectively inhibits fusion between pinocytic vesicles and lysosomes during heterophagy of 125I-asialofetuin by the perfused rat liver.

1980 • 451 citations

Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells [published erratum appears in J Cell Biol 1990 Mar;110(3):859]

1989 • 448 citations

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

1990 • 445 citations

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

1994 • 442 citations

Vitamin A metabolism: new perspectives on absorption, transport, and storage

1991 • 433 citations

Movement of internalized ligand–receptor complexes along a continuous endosomal reticulum

1990 • 428 citations

Isolation and characterization of the intracellular MHC class II compartment

1994 • 426 citations

Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle

1992 • 414 citations

Penetration of semliki forest virus from acidic prelysosomal vacuoles

1983 • 411 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

Changes in lysosome shape and distribution correlated with changes in cytoplasmic pH.

1989 • 387 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

1992 • 380 citations

The Phosphomannosyl Recognition System for Intracellular and Intercellular Transport of Lysosomal Enzymes

1982 • 379 citations

An essential role for HLA–DM in antigen presentation by class II major histocompatibility molecules

1994 • 378 citations

Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment

1990 • 377 citations

The coated pit and macropinocytic pathways serve distinct endosome populations

1994 • 374 citations

Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells

1994 • 349 citations

Role for intracellular proteases in the processing and transport of class II HLA antigens.

1988 • 336 citations

Macropinosome maturation and fusion with tubular lysosomes in macrophages.

1993 • 332 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

A radioiodinated, intracellularly trapped ligand for determining the sites of plasma protein degradation in vivo

1983 • 317 citations

Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens

1982 • 308 citations

Insulin Degradation: Mechanisms, Products, and Significance*

1988 • 305 citations

Targeting of membrane proteins to endosomes and lysosomes

1994 • 304 citations

Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity.

1984 • 299 citations

Immunocytochemical characterization of the endocytic and phagolysosomal compartments in peritoneal macrophages.

1992 • 277 citations

A role for peptide in determining MHC class II structure

1991 • 275 citations

Endosome pH measured in single cells by dual fluorescence flow cytometry: rapid acidification of insulin to pH 6.

1984 • 275 citations

Prelysosomal convergence of autophagic and endocytic pathways

1988 • 272 citations

Tubular lysosome morphology and distribution within macrophages depend on the integrity of cytoplasmic microtubules.

1987 • 270 citations

Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: ligand and receptor dynamics.

1984 • 265 citations

Cathepsin D is membrane-associated in macrophage endosomes.

1988 • 259 citations

A new human HLA class II-related locus, DM

1991 • 251 citations

Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cells

1991 • 250 citations

HLA-DMA and DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells

1994 • 247 citations

Reduction of disulfide bonds within lysosomes is a key step in antigen processing.

1991 • 245 citations

Macrophage colony-stimulating factor (rM-CSF) stimulates pinocytosis in bone marrow-derived macrophages.

1989 • 242 citations

Phorbol esters stimulate macropinocytosis and solute flow through macrophages

1989 • 240 citations

The Ways of Endocytosis

1989 • 237 citations

Biosynthesis and transport of cathepsin D in cultured human fibroblasts.

1983 • 235 citations

Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.

1991 • 234 citations

The Peripheral Metabolism of Parathyroid Hormone

1979 • 233 citations

A possible role for Na+,K+-ATPase in regulating ATP-dependent endosome acidification.

1989 • 229 citations

The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi.

1992 • 225 citations

Binding and uptake of 125I-insulin into rat liver hepatocytes and endothelium. An in vivo radioautographic study.

1979 • 223 citations

Macrophage endosomes contain proteases which degrade endocytosed protein ligands.

1985 • 223 citations

Separation of subcellular compartments containing distinct functional forms of MHC class II.

1994 • 221 citations

Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization.

1993 • 221 citations

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.

1992 • 219 citations

Invariant Chain Peptides in Most HLA-DR Molecules of an Antigen-Processing Mutant

1992 • 218 citations

Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: receptor pathway.

1986 • 217 citations

Exocytosis of pinocytosed fluid in cultured cells: kinetic evidence for rapid turnover and compartmentation.

1981 • 215 citations

Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain.

1990 • 214 citations

Mass isolation and culture of rat kupffer cells.

1975 • 214 citations

The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail.

1993 • 206 citations

Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules.

1992 • 197 citations

The role of intermediate vesicles in the adsorptive endocytosis and transport of ligand to lysosomes by human fibroblasts.

1983 • 196 citations

In vivo uptake of chylomicron [3H]retinyl ester by rat liver: evidence for retinol transfer from parenchymal to nonparenchymal cells.

1982 • 190 citations

Sorting signals in the MHC class II invariant chain cytoplasmic tail and transmembrane region determine trafficking to an endocytic processing compartment.

1994 • 188 citations

M-CSF-induced macropinocytosis increases solute endocytosis but not receptor-mediated endocytosis in mouse macrophages

1992 • 188 citations

Delivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomes

1992 • 187 citations

Endocytosis: what goes in and how?

1992 • 177 citations

Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-Ak.

1992 • 174 citations

Maturation models for endosome and lysosome biogenesis

1991 • 172 citations

Class II MHC molecules are present in macrophage lysosomes and phagolysosomes that function in the phagocytic processing of Listeria monocytogenes for presentation to T cells.

1992 • 167 citations

Liposome-encapsulated antigens engender lysosomal processing for class II MHC presentation and cytosolic processing for class I presentation.

1991 • 164 citations

Distribution of newly synthesized lysosomal enzymes in the endocytic pathway of normal rat kidney cells.

1991 • 164 citations

Uptake of Insulin and Other Ligands into Receptor-Rich Endocytic Components of Target Cells: The Endosomal Apparatus

1985 • 163 citations

Characterization of the cation-independent mannose 6-phosphate receptor-enriched prelysosomal compartment in NRK cells

1990 • 161 citations

Identification of latent procathepsins B and L in microsomal lumen: Characterization of enzymatic activation and proteolytic processing in vitro

1988 • 161 citations

Retinoids, retinoid-binding proteins, and retinyl palmitate hydrolase distributions in different types of rat liver cells.

1985 • 161 citations

Theearly andlate processing of lysosomal enzymes: Proteolysis and compartmentation

1992 • 160 citations

The specificity of cathepsin B. Hydrolysis of glucagon at the C-terminus by a peptidyldipeptidase mechanism

1978 • 159 citations

Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells.

1990 • 159 citations

Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture.

1991 • 158 citations

The arguments for pre-existing early and late endosomes

1991 • 156 citations

Multivesicular bodies in HEp-2 cells are maturing endosomes.

1993 • 154 citations

Identification of proteases that process distinct epitopes on the same protein.

1989 • 147 citations

Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments.

1993 • 146 citations

Intracellular transport and localization of major histocompatibility complex class II molecules and associated invariant chain.

1991 • 145 citations

Selective modulation of the endocytic uptake of ricin and fluid phase markers without alteration in transferrin endocytosis.

1990 • 145 citations

Molecular Cloning and Functional Characterization of Chicken Cathepsin D, a Key Enzyme for Yolk Formation

1992 • 142 citations

Fusion of newly formed phagosomes with endosomes in intact cells and in a cell-free system.

1991 • 141 citations

Isolated parenchymal, Kupffer and endothelial rat liver cells characterized by their lysosomal enzyme content

1980 • 139 citations

Metabolism of bovine parathyroid hormone. Immunological and biological characteristics of fragments generated by liver perfusion.

1975 • 135 citations

Intralysosomal hydrolysis of glycyl-<scp>l</scp>-phenylalanine 2-naphthylamide

1984 • 132 citations

An LI and ML motif in the cytoplasmic tail of the MHC-associated invariant chain mediate rapid internalization

1994 • 131 citations

Cleavage of Parathyroid Hormone in Macrophage Endosomes Illustrates a Novel Pathway for Intracellular Processing of Proteins

1989 • 131 citations

Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit.

1990 • 130 citations

Capacity of intact proteins to bind to MHC class II molecules.

1989 • 129 citations

Kinetics and temperature dependence of exposure of endocytosed material to proteolytic enzymes and low pH: Evidence for a maturation model for the formation of lysosomes

1987 • 126 citations

Immunogenic peptides bind to class II MHC molecules in an early lysosomal compartment.

1993 • 124 citations

Hepatocytic lipoprotein receptors and intracellular lipoprotein catabolism

1988 • 124 citations

Immunolocalization of cytoplasmic dynein to lysosomes in cultured cells

1992 • 122 citations

Receptor-mediated endocytosis of asialoglycoproteins by rat hepatocytes: receptor-positive and receptor-negative endosomes.

1986 • 121 citations

Inhibition of insulin degradation by hepatoma cells after microinjection of monoclonal antibodies to a specific cytosolic protease.

1986 • 118 citations

Evidence for retrograde traffic between terminal lysosomes and the prelysosomal/late endosome compartment

1994 • 117 citations

Internalization and Activation of the Rat Liver Insulin Receptor Kinase in vivo

1989 • 116 citations

Kinetics of endosome acidification detected by mutant and wild-type Semliki Forest virus.

1986 • 115 citations

Different roles for thiol and aspartyl proteases in antigen presentation of ovalbumin.

1990 • 113 citations

Distribution of lysosomal enzymes between parenchymal and Kupffer cells of rat liver

1973 • 112 citations

Transport of phagosomal components to an endosomal compartment.

1992 • 110 citations

Endosomal proteolysis of insulin by an acidic thiol metalloprotease unrelated to insulin degrading enzyme.

1994 • 110 citations

Receptor-mediated endocytosis of asialoglycoproteins by rat liver hepatocytes: biochemical characterization of the endosomal compartments.

1985 • 109 citations

The invariant chain of murine ia antigens: Its glycosylation, abundance and subcellular localization

1981 • 108 citations

Inactivation of Glucagon by Plasma Membranes of Rat Liver

1972 • 108 citations

Metabolism of Parathyroid Hormone by Isolated Rat Kupffer Cells and Hepatocytes

1981 • 108 citations

Selective degradation of insulin within rat liver endosomes.

1990 • 106 citations

Molecules internalized by clathrin-independent endocytosis are delivered to endosomes containing transferrin receptors.

1993 • 104 citations

Peptide Binding to Major Histocompatibility Complex Molecules

1993 • 104 citations

Plasticity of the tubular lysosomal compartment in macrophages

1990 • 103 citations

Effect of chloroquine on the internalization of 125I-insulin into subcellular fractions of rat liver. Evidence for an effect of chloroquine on Golgi elements.

1982 • 102 citations

Ligand-mediated autophosphorylation activity of the epidermal growth factor receptor during internalization.

1989 • 101 citations

Isolation and characterization of three endosomal fractions from the liver of estradiol-treated rats.

1987 • 101 citations

Distribution of lysosomal enzymes in different types of rat liver cells

1976 • 101 citations

Isolation of insulin degradation products from endosomes derived from intact rat liver.

1988 • 99 citations

Internalization of insulin into rat liver Golgi elements. Evidence for vesicle heterogeneity and the path of intracellular processing.

1982 • 98 citations

The preendosomal compartment comprises distinct coated and noncoated endocytic vesicle populations.

1991 • 97 citations

Peripheral Metabolism of Intact Parathyroid Hormone

1981 • 96 citations

Selective Uptake of the Synthetic Amino Terminal Fragment of Bovine Parathyroid Hormone by Isolated Perfused Bone

1978 • 96 citations

Degradation products of insulin generated by hepatocytes and by insulin protease.

1988 • 95 citations

Stable surface expression of invariant chain prevents peptide presentation by HLA-DR.

1992 • 94 citations

Invariant chain promotes egress of poorly expressed, haplotype-mismatched class II major histocompatibility complex A alpha A beta dimers from the endoplasmic reticulum/cis-Golgi compartment.

1991 • 94 citations

Hyperosmolarity inhibits galactosyl receptor-mediated but not fluid phase endocytosis in isolated rat hepatocytes

1989 • 94 citations

Intracellular pools of transferrin receptors result from constitutive internalization of unoccupied receptors.

1986 • 94 citations

A high molecular weight metalloendoprotease from the cytosol of mammalian cells.

1983 • 93 citations

Differential postendocytotic compartmentation in Xenopus oocytes is mediated by a specifically bound ligand

1980 • 91 citations

Identification of subcellular compartments involved in biosynthetic processing of cathepsin D.

1992 • 90 citations

Specific proteolysis regulates fusion between endocytic compartments in Xenopus oocytes

1987 • 87 citations

Antigen presentation by hapten-specific B lymphocytes. II. Specificity and properties of antigen-presenting B lymphocytes, and function of immunoglobulin receptors.

1985 • 87 citations

Insulin and Glucagon Degradation by the Same Enzyme

1974 • 87 citations

MHC molecules protect T cell epitopes against proteolytic destruction.

1992 • 87 citations

Proteolytic cleavage of ricin A chain in endosomal vesicles. Evidence for the action of endosomal proteases at both neutral and acidic pH.

1991 • 87 citations

MHC class II antigen processing: biology of invariant chain

1994 • 83 citations

George Lyman Duff memorial lecture. Role of the liver in atherosclerosis.

1985 • 81 citations

Functional and ultrastructural evidence for intracellular formation of major histocompatibility complex class II-peptide complexes during antigen processing.

1990 • 81 citations

Monensin inhibits receptor-mediated endocytosis of asialoglycoproteins in rat hepatocytes

1983 • 78 citations

Insulin Degradation by Hepatocytes in Primary Culture*

1981 • 78 citations

Analysis of Parathyroid Hormone and Its Fragments in Rat Tissues

1979 • 78 citations

Activation of procathepsin B in human hepatoma cells: the conversion into the mature enzyme relies on the action of cathepsin B itself

1993 • 77 citations

Intracellular transport of asialoglycoproteins in rat hepatocytes

1985 • 76 citations

The generation of immunogenic peptides can be selectively increased or decreased by proteolytic enzyme inhibitors.

1991 • 75 citations

A group-specific inhibitor of lysosomal cysteine proteinases selectively inhibits both proteolytic degradation and presentation of the antigen dinitrophenyl-poly-L-lysine by guinea pig accessory cells to T cells.

1986 • 74 citations

Rat insulin-degrading enzyme: cleavage pattern of the natriuretic peptide hormones ANP, BNP, and CNP revealed by HPLC and mass spectrometry

1992 • 74 citations

Reconstitution of an endosome-lysosome interaction in a cell-free system.

1989 • 74 citations

Antigen processing by endosomal proteases determines which sites of sperm‐whale myoglobin are eventually recognized by T cells

1991 • 74 citations

Dissociation of ionizing groups in the binding cleft inversely controls the endo- and exopeptidase activities of cathepsin B.

1987 • 72 citations

Intracellular processing of epidermal growth factor and its effect on ligand-receptor interactions.

1985 • 71 citations

An unusual lysosome compartment involved in vitellogenin endocytosis by Xenopus oocytes.

1985 • 71 citations

Evidence that aspartic proteinase is involved in the proteolytic processing event of procathepsin L in lysosomes

1989 • 70 citations

Atrial natriuretic peptide (ANP) is a high‐affinity substrate for rat insulin‐degrading enzyme

1991 • 69 citations

Unaltered catabolism of desialylated low-density lipoprotein in the pig and in cultured rat hepatocytes

1979 • 67 citations

Lysosomal enzyme precursors in coated vesicles derived from the exocytic and endocytic pathways.

1987 • 66 citations

Lipoprotein receptors, plasma cholesterol metabolism, and the regulation of cellular free cholesterol concentration

1992 • 65 citations

Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography. Autocatalytic proteolysis of the zymogen form of the enzyme

1989 • 64 citations

The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells.

1990 • 63 citations

Degradation of epidermal growth factor receptor in rat liver. Membrane topology through the lysosomal pathway.

1991 • 60 citations

Acid hydrolases in early and late endosome fractions from rat liver.

1991 • 58 citations

The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail

1993 • 58 citations

Intracellular distribution of the MHC class II molecules and the associated invariant chain (li) in different cell lines

1993 • 58 citations

Inhibition by bacitracin of rat adipocyte plasma membrane degradation of 125I-insulin is associated with an increase in plasma membrane bound insulin and a potentiation of glucose oxidation by adipocytes.

1982 • 56 citations

Are caveolae involved in clathrin-independent endocytosis?

1993 • 56 citations

Intracellular processing of epidermal growth factor. I. Acidification of 125I-epidermal growth factor in intracellular organelles.

1984 • 54 citations

Glucagon-(19-29), a Ca2+ pump inhibitory peptide, is processed from glucagon in the rat liver plasma membrane by a thiol endopeptidase.

1990 • 51 citations

Sequential processing of epidermal growth factor in early and late endosomes of rat liver

1991 • 51 citations

The effect of leupeptin on intracellular digestion of asialofetuin in rat hepatocytes

1981 • 51 citations

Processing and Transport of the Precursor of Cathepsin C during Its Transfer into Lysosomes

1993 • 50 citations

Proteolytic processing of epidermal growth factor within endosomes

1987 • 50 citations

Receptor-mediated endocytosis and degradation of insulin.

1988 • 49 citations

Intracellular processing of epidermal growth factor. II. Intracellular cleavage of the COOH-terminal region of 125I-epidermal growth factor.

1984 • 49 citations

Differential and analytical subfraction of rat liver components internalizing insulin and prolactin

1986 • 49 citations

Activation of Kupffer cells on reperfusion following hypoxia: particle phagocytosis in a low-flow, reflow model

1992 • 48 citations

Inhibitor studies indicate that active cathepsin L is probably essential to its own processing in cultured fibroblasts

1990 • 48 citations

Isolation and characterization of three endosomal fractions from the liver of normal rats after lipoprotein loading

1991 • 47 citations

Ultrastructural localization of the regulatory (RII) subunit of cyclic AMP-dependent protein kinase to subcellular compartments active in endocytosis and recycling of membrane receptors

1990 • 47 citations

Intracellular transport of endocytosed chylomicron [3H]retinyl ester in rat liver parenchymal cells. Evidence for translocation of a [3H]retinoid from endosomes to endoplasmic reticulum.

1985 • 47 citations

Lymphatic absorption and transport of retinol and vitamin D-3 from rat intestine Evidence for different pathways

1984 • 44 citations

Regulation of Insulin Degradation: Expression of an Evolutionarily Conserved Insulin-Degrading Enzyme Increases Degradation via an Intracellular Pathway

1991 • 43 citations

Characterization of parathyroid hormone fragments produced by cathepsin D.

1985 • 42 citations

A block in degradation of mhc class ii-associated invariant chain correlates with a reduction in transport from endosome carrier vesicles to the prelysosome compartment

1992 • 40 citations

Time Course of Intracellular Associations, Processing, and Cleavages of Ii Forms and Class II Major Histocompatibility Complex Molecules

1989 • 39 citations

Rat plasma clearance of horseradish peroxidase and yeast invertase is mediated by specific recognition

1978 • 39 citations

Monensin inhibits ligand dissociation only transiently and partially and distinguishes two galactosyl receptor pathways in isolated rat hepatocytes

1987 • 38 citations

Reconstitution of Endosomal Proteolysis in a Cell-free System

1989 • 38 citations

In vivo uptake of insulin into hepatic golgi fractions: Application of the diaminobenzidine-shift protocol

1984 • 37 citations

Exogenous antigens internalized through transferrin receptors activate CD4+ T cells.

1993 • 36 citations

Production of biologically active fragments of parathyroid hormone by isolated Kupffer cells.

1986 • 35 citations

Low‐temperature inhibition of antigen processing and iron uptake from transferrin: Deficits in endosome functions at 18 °C

1990 • 34 citations

Stabilisation of cathepsin E by ATP

1989 • 34 citations

Hydrolases in intracellular compartments of rat liver cells

1991 • 34 citations

Membrane translocation of diphtheria toxin A-fragment: role of carboxy-terminal region

1993 • 33 citations

In vitro translation and processing of cathepsin B of Schistosoma mansoni.

1990 • 33 citations

The processing of a cathepsin L precursor in vitro

1989 • 33 citations

Conversion of dense lysosomes into light lysosomes during hepatocytic autophagy

1985 • 32 citations

Degradation of Insulin and Insulin-Like Growth Factors by Enzyme Purified From Human Erythrocytes: Comparison of Degradation Products Observed With A14- and B26-[125I]monoiodoinsulin

1989 • 32 citations

Identification of latent procathepsin H in microsomal lumen: Characterization of proteolytic processing and enzyme activation

1988 • 30 citations

Insulin proteinase liberates from glucagon a fragment known to have enhanced activity against Ca2+ + Mg2+-dependent ATPase

1988 • 30 citations

Synthesis, transport and processing of cathepsin C in Morris hepatoma 7777 cells and rat hepatocytes

1985 • 30 citations

Insulin and Insulin Receptor Uptake into Rat Liver: Chloroquine Action on Receptor Recycling

1985 • 29 citations

A pool of intracellular phosphorylated asialoglycoprotein receptors which is not involved in endocytosis.

1991 • 29 citations

Cathepsinogen D: characterization and activation to cathepsin D and inhibitory peptides

1981 • 28 citations

The effect of vanadate on receptor-mediated endocytosis of asialoorosomucoid in rat liver parenchymal cells.

1990 • 27 citations

Characterization of insulin degradation by rat-liver low-density vesicles

1987 • 26 citations

The surface activity of the same subpopulation of galactosyl receptors on isolated rat hepatocytes is modulated by colchicine, monensin, ATP depletion, and chloroquine.

1990 • 26 citations

Fate of injected glucagon taken up by rat liver in vivo. Degradation of internalized ligand in the endosomal compartment

1990 • 26 citations

Characterization of insulin degradation products generated in liver endosomes: In vivo and in vitro studies

1990 • 26 citations

Degradation of glucagon in isolated liver endosomes. ATP-dependence and partial characterization of degradation products

1991 • 24 citations

Immunological significances of invariant chain from the aspect of its structural homology with the cystatin family

1994 • 23 citations

Receptor-linked proteolysis of membrane-bound glucagon yields a membrane-associated hormone fragment.

1988 • 22 citations

Intracellular degradation of 125I-labelled asialo-glycoproteins in rat hepatocytes: Effect of leupeptin on subcellular distribution of asialo-fetuin

1981 • 22 citations

Characterization of a glucagon receptor-linked protease from canine hepatic plasma membranes. Partial purification, kinetic analysis, and determination of sites for hormone processing.

1988 • 22 citations

Degradation of insulin in isolated liver endosomes is functionally linked to ATP‐dependent endosomal acidification

1990 • 22 citations

Quantitation of acid phosphatase and aryl sulphatase in rat hepatic parenchymal and kupffer cells

1973 • 20 citations

Total cellular activity and distribution of a subpopulation of galactosyl receptors in isolated rat hepatocytes are differentially affected by microtubule drugs, monensin, low temperature, and chloroquine

1991 • 20 citations

Hepatic processing of insulin

1989 • 20 citations

Triacylglycerol hydrolysis in isolated hepatic endosomes.

1992 • 20 citations

Analytical Subcellular Fractionation of Endosomal Compartments in Rat Hepatocytes

1993 • 19 citations

Intracellular degradation of asialoglycoproteins in hepatocytes starts in a subgroup of lysosomes

1985 • 19 citations

The relationship between autophagy and the intracellular degradation of asialoglycoproteins in cultured rat hepatocytes.

1987 • 18 citations

Proteolytic Processing in Endosomal Vesicles

1989 • 17 citations

Identification of Monkey Lung Procathepsin <scp>d</scp>‐II as a Pepsinogen‐C‐Like Acid Protease Zymogen

1983 • 17 citations

Does the EcoRI polymorphism in the human apolipoprotein B gene affect the binding of low density lipoprotein to the low density lipoprotein receptor?

1992 • 17 citations

Effect on lysosomes of invertase endocytosed by rat-liver

1985 • 17 citations

Intracellular transport of endocytosed proteins in rat liver endothelial cells

1990 • 17 citations

Lysosomal and endosomal heterogeneity in the liver: A comparison of the intracellular pathways of endocytosis in rat liver cells

1991 • 17 citations

Uptake and intracellular transport in rat liver of formaldehyde‐treated bovine serum albumin labelled with ¹²⁵I‐tyramine‐cellobiose

1988 • 16 citations

Intracellular processing of ¹²⁵I‐epidermal growth factor in rat embryo fibroblasts

1982 • 16 citations

Intracellular Modification of¹²⁵I-Labeled Epidermal Growth Factor by Normal Human Foreskin Fibroblasts*

1986 • 16 citations

Transient membrane association of the precursors of cathepsin C during their transfer into lysosomes

1991 • 15 citations

Effect of glycyl-<scp>l</scp>-phenylalanine 2-naphthylamide on invertase endocytosed by rat liver

1985 • 15 citations

Antigen presentation by B lymphoma cells. Requirements for processing of exogenous antigen internalized through transferrin receptors.

1993 • 14 citations

Disruption of intracellular processing of epidermal growth factor by methylamine inhibits epidermal growth factor-induced DNA synthesis but not early morphological or transcriptional events.

1987 • 14 citations

Prolactin uptake into liver endocytic components. Reduced sensitivity to chloroquine

1985 • 14 citations

Intracellular pathway followed by invertase endocytosed by rat liver

1986 • 14 citations

Possible role of cell surface insulin degrading enzyme in cultured human lymphocytes

1987 • 13 citations

Isolation of Kupffer cell lysosomes, with observations on their chemical and enzymic composition

1974 • 13 citations

Uptake of yeast invertase by rat liver cells in vivo and in vitro

1978 • 13 citations

Reconstitution of Endosomal Transport and Proteolysis

1993 • 10 citations

Lysosomal enzymes in cultured rat kupffer cells

1977 • 10 citations

Fate of asialofetuin endocytosed by rat liver

1989 • 9 citations

Chloroquine Allows to Distinguish between Hepatocyte Lysosomes and Sinusoidal Cell Lysosomes

1993 • 8 citations

Potential Role of Endosomes in Transmembrane Signaling

1993 • 7 citations

The Influence of Cortisone on the Hepatic Uptake of Triton WR-1339 in Adrenalectomized Rats

1975 • 7 citations

Binding and degradation of 125I-glucagon by highly purified rat liver plasma membranes

1986 • 6 citations

Characterization of Endocytic Components of Liver Nonparenchymal Cells

1993 • 4 citations

EXPRESSION OF HLA CLASS II ANTIGEN-ASSOCIATED INVARIANT CHAIN ON RENAL CELL CANCER

1993 • 3 citations

Proteolytic processing of epidermal growth factor within endosomes

1986 • 1 citations