Peptide Binding to Major Histocompatibility Complex Molecules

Protein folding in the cell

1992 • 4,138 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS

1986 • 1,977 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Association of class I major histocompatibility heavy and light chains induced by viral peptides

1989 • 995 citations

A Role for a 70-Kilodalton Heat Shock Protein in Lysosomal Degradation of Intracellular Proteins

1989 • 932 citations

Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2K ^b

1992 • 864 citations

Identification of self peptides bound to purified HLA-B27

1991 • 844 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Emerging Principles for the Recognition of Peptide Antigens by MHC Class I Molecules

1992 • 730 citations

Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters

1990 • 717 citations

An Fc receptor structurally related to MHC class I antigens

1989 • 711 citations

Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.

1983 • 701 citations

STRUCTURE, FUNCTION, AND DIVERSITY OF CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULES

1990 • 693 citations

The three-dimensional structure of HLA-B27 at 2.1 Å resolution suggests a general mechanism for tight peptide binding to MHC

1992 • 670 citations

Cytotoxic T cells recognize fragments of the influenza nucleoprotein

1985 • 669 citations

The class II molecules of the human and murine major histocompatibility complex

1984 • 664 citations

Specificity pockets for the side chains of peptide antigens in HLA-Aw68

1989 • 664 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway

1990 • 644 citations

CDlb restricts the response of human CD4−8−T lymphocytes to a microbial antigen

1992 • 577 citations

Proteolysis, proteasomes and antigen presentation

1992 • 576 citations

Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.

1982 • 576 citations

HLA-A2.1-Associated Peptides from a Mutant Cell Line: A Second Pathway of Antigen Presentation

1992 • 522 citations

HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

1992 • 502 citations

Assembly of MHC class I molecules analyzed in vitro

1990 • 491 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

Isolation and characterization of antigen-la complexes involved in T cell recognition

1986 • 470 citations

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

1990 • 445 citations

Transport Protein Genes in the Murine MHC: Possible Implications for Antigen Processing

1990 • 438 citations

MHC class II region encoding proteins related to the muKidrug resistance family of transmembrane transporters

1990 • 426 citations

Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes

1991 • 425 citations

Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex

1992 • 407 citations

Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment

1990 • 377 citations

Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

1987 • 367 citations

A pentapeptide as minimal antigenic determinant for MHC class I-restricted T lymphocytes

1989 • 339 citations

Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis

1991 • 336 citations

Human major histocompatibility complex contains genes for the major heat shock protein HSP70.

1989 • 336 citations

Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen.

1988 • 331 citations

Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

1991 • 326 citations

Evolution of the major histocompatibility complex.

1986 • 326 citations

Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer

1992 • 322 citations

The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide

1992 • 306 citations

Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition.

1992 • 295 citations

A role for peptide in determining MHC class II structure

1991 • 275 citations

Class II MHC molecules can use the endogenous pathway of antigen presentation

1990 • 271 citations

CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo.

1992 • 260 citations

Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene

1991 • 256 citations

Atomic structure of a human MHC molecule presenting an influenza virus peptide

1992 • 254 citations

Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation

1992 • 250 citations

A peptide binding protein having a role in antigen presentation is a member of the HSP70 heat shock family.

1989 • 246 citations

Sequence motifs important for peptide binding to the human MHC class I molecule, HLA-A2.

1992 • 246 citations

Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes

1990 • 236 citations

Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs

1992 • 234 citations

Identification of a motif for HLA-DR1 binding peptides using M13 display libraries.

1992 • 224 citations

Peptide-induced conformational change of the class I heavy chain

1991 • 221 citations

Invariant Chain Peptides in Most HLA-DR Molecules of an Antigen-Processing Mutant

1992 • 218 citations

Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules

1992 • 215 citations

Location of MHC-encoded transporters in the endoplasmic reticulum and cis-Golgi

1992 • 208 citations

Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment.

1992 • 204 citations

HLA class II-restricted presentation of cytoplasmic measles virus antigens to cytotoxic T cells

1989 • 201 citations

Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells

1992 • 201 citations

A hypothetical model for the peptide binding domain of hsp70 based on the peptide binding domain of HLA.

1991 • 191 citations

Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex.

1992 • 190 citations

Processed antigen binds to newly synthesized mhc class II molecules in antigen-specific B lymphocytes

1991 • 188 citations

An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cells.

1990 • 188 citations

The binding affinity and dissociation rates of peptides for class I major histocompatibility complex molecules

1991 • 187 citations

Efficient dissociation of the p88 chaperone from major histocompatibility complex class I molecules requires both beta 2-microglobulin and peptide.

1992 • 184 citations

The Role of β₂-Microglobulin in Peptide Binding by Class I Molecules

1990 • 179 citations

Cytotoxic T lymphocytes against a soluble protein

1987 • 178 citations

Multi-pin peptide synthesis strategy for T cell determinant analysis

1990 • 174 citations

Single amino acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition.

1991 • 159 citations

Autologous Peptides Constitutively Occupy the Antigen Binding Site on Ia

1988 • 157 citations

Peptide ligand-induced conformation and surface expression of the Ld class I MHC molecule

1990 • 155 citations

HLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cells.

1992 • 148 citations

Endogenous peptides of a soluble major histocompatibility complex class I molecule, H-2Lds: sequence motif, quantitative binding, and molecular modeling of the complex.

1992 • 146 citations

Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus.

1991 • 146 citations

Functionally conformed free class I heavy chains exist on the surface of beta 2 microglobulin negative cells.

1992 • 146 citations

H-2Kd-restricted antigenic peptides share a simple binding motif.

1991 • 145 citations

A case for chaperones in antigen processing

1992 • 143 citations

Cell surface expression of class II histocompatibility antigens occurs in the absence of the invariant chain.

1986 • 142 citations

Peptide binding to empty HLA-B27 molecules of viable human cells

1991 • 137 citations

Activated human T lymphocytes express MHC class I heavy chains not associated with beta 2-microglobulin.

1990 • 134 citations

Which came first, MHC class I or class II?

1991 • 132 citations

The Structure of T-Cell Epitopes

1987 • 130 citations

A kinetic intermediate in the reaction of an antigenic peptide and I–Ek

1989 • 122 citations

Identification of a peptide binding protein that plays a role in antigen presentation.

1987 • 112 citations

The p88 molecular chaperone is identical to the endoplasmic reticulum membrane protein, calnexin.

1992 • 110 citations

Cytotoxic T cell recognition of an endogenous class I HLA peptide presented by a class II HLA molecule.

1990 • 109 citations

Reconstitution by MHC-restricted peptides of HLA-A2 heavy chain with β2-microglobulin, in vitro

1991 • 104 citations

A trans-acting major histocompatibility complex-linked gene whose alleles determine gain and loss changes in the antigenic structure of a classical class I molecule.

1989 • 94 citations

ATP is required for in vitro assembly of MHC class I antigens but not to transfer of peptides acrosss the ER membrane

1991 • 92 citations

Presentation of three different viral peptides, HTLV-1 Tax, HCMV gB, and influenza virus M1, is determined by common structural features of the HLA-A2.1 molecule.

1992 • 92 citations

MHC molecules protect T cell epitopes against proteolytic destruction.

1992 • 87 citations

Structure-function analysis of the Abm12 beta mutation using site-directed mutagenesis and DNA-mediated gene transfer.

1987 • 86 citations

Self-peptide released from class II HLA-DR1 exhibits a hydrophobic two-residue contact motif.

1992 • 85 citations

Binding of labelled influenza matrix peptide to HLA DR in living B lymphoid cells

1989 • 85 citations

HLA-DR light chain has a polymorphic N-terminal region and a conserved immunoglobulin-like C-terminal region

1982 • 84 citations

The generation of immunogenic peptides can be selectively increased or decreased by proteolytic enzyme inhibitors.

1991 • 75 citations

The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene.

1992 • 74 citations

A Critical Role for Conserved Residues in the Cleft of HLA-A2 in Presentation of a Nonapeptide to T Cells

1992 • 72 citations

Class I-restricted presentation occurs without internalization or processing of exogenous antigenic peptides.

1989 • 66 citations

Identical peptides recognized by MHC class I- and II-restricted T cells.

1989 • 63 citations

Class I MHC can present an endogenous peptide to cytotoxic T lymphocytes.

1989 • 62 citations

Comparison of the secondary structures of human class I and class II major histocompatibility complex antigens by Fourier transform infrared and circular dichroism spectroscopy.

1989 • 61 citations

Regulation of Qa-1 expression and determinant modification by an H-2D-linked gene, Qdm

1988 • 59 citations

Presentation of viral antigen to class I major histocompatibility complex-restricted cytotoxic T lymphocyte. Recognition of an immunodominant influenza hemagglutinin site by cytotoxic T lymphocyte is independent of the position of the site in the hemagglutinin translation product.

1991 • 58 citations

Specific binding of antigenic peptides to cell-associated MHC class I molecules

1991 • 57 citations

How do peptides associate with MHC class I molecules?

1991 • 55 citations

A 15 amino acid fragment of influenza nucleoprotein synthesized in the cytoplasm is presented to class I-restricted cytotoxic T lymphocytes.

1989 • 51 citations

E3/19K from adenovirus 2 is an immunosubversive protein that binds to a structural motif regulating the intracellular transport of major histocompatibility complex class I proteins.

1990 • 48 citations

Changes in the repertoire of peptides bound to HLA-B27 subtypes and to site-specific mutants inside and outside pocket B.

1993 • 41 citations

Long-lived complexes between peptide and class II major histocompatibility complex are formed at low pH with no requirement for pH neutralization.

1992 • 40 citations

pH dependence of the interaction between immunogenic peptides and MHC class II molecules. Evidence for an acidic intracellular compartment being the organelle of interaction.

1992 • 40 citations

Identification of an immunodominant region on the I-A beta chain using site-directed mutagenesis and DNA-mediated gene transfer.

1988 • 39 citations

Kinetics of antigenic peptide binding to the class II major histocompatibility molecule I-Ad.

1991 • 39 citations

Analysis of the association of peptides of optimal length to class I molecules on the surface of cells.

1992 • 35 citations

In vitro maximum binding of antigenic peptides to murine MHC class II molecules does not always take place at the acidic pH of the in vivo endosomal compartment.

1992 • 22 citations

The role of polymorphic I-Ak beta chain residues in presentation of a peptide from myelin basic protein.

1989 • 12 citations