Regulation of Insulin Degradation: Expression of an Evolutionarily Conserved Insulin-Degrading Enzyme Increases Degradation via an Intracellular Pathway

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

1976 • 601 citations

Binding and degradation of 125I-insulin by rat hepatocytes.

1975 • 419 citations

Molecular Basis of Insulin Action

1985 • 309 citations

Insulin Degradation: Mechanisms, Products, and Significance*

1988 • 305 citations

Mechanisms of DNA uptake by mammalian cells: fate of exogenously added DNA monitored by the use of fluorescent dyes.

1982 • 229 citations

Purification of Insulin-Specific Protease by Affinity Chromatography

1972 • 119 citations

The inactivation of insulin by tissue extracts; the distribution and properties of insulin inactivating extracts.

1949 • 118 citations

Inhibition of insulin degradation by hepatoma cells after microinjection of monoclonal antibodies to a specific cytosolic protease.

1986 • 118 citations

Isolation of insulin degradation products from endosomes derived from intact rat liver.

1988 • 99 citations

Mode of uptake and degradation of ¹²⁵I-labelled insulin by isolated hepatocytes and H4 hepatoma cells

1979 • 94 citations

Degradation of Intraendosomal Insulin by Insulin-Degrading Enzyme Without Acidification

1991 • 82 citations

Insulin-Degrading Enzyme: Stable Expression of the Human Complementary DNA, Characterization of its Protein Product, and Chromosomal Mapping of the Human and Mouse Genes

1990 • 69 citations

Regulation of Insulin, Epidermal Growth Factor, and Transforming Growth Factor-α Levels by Growth Factor-Degrading Enzymes*

1991 • 65 citations

Insulin processing by the liver.

1982 • 65 citations

The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells.

1990 • 63 citations

Cloning and Expression of the cDNA for aDrosophilaInsulin-Degrading Enzyme

1990 • 62 citations

Degradative processing of internalized insulin in isolated adipocytes.

1985 • 55 citations

HPLC Analysis of Insulin Degradation Products From Isolated Hepatocytes: Effects of Inhibitors Suggest Intracellular and Extracellular Pathways

1987 • 46 citations

Purification and Characterization of Insulin-Degrading Enzyme from Pig Skeletal Muscle

1981 • 44 citations

Retroendocytosis of Insulin in Rat Adipocytes*

1986 • 43 citations

Isolation and characterization of an insulin-degrading enzyme from Drosophila melanogaster

1988 • 42 citations

Human red blood cell insulin-degrading enzyme and rat skeletal muscle insulin protease share antigenic sites and generate identical products from insulin.

1990 • 37 citations

Cellular localization of insulin-degrading enzyme in rat liver using monoclonal antibodies specific for this enzyme

1988 • 32 citations

Drosophila insulin degrading enzyme and rat skeletal muscle insulin protease cleave insulin at similar sites

1989 • 31 citations

Insulin-degrading enzyme is capable of degrading receptor-bound insulin

1988 • 28 citations

Degradation of insulin in isolated liver endosomes is functionally linked to ATP‐dependent endosomal acidification

1990 • 22 citations

Effects of Lysosomal Inhibitors on 125I-Insulin and 125I-Asialofetuin Degradation by the Isolated, Perfused Rat Liver and Isolated Rat Hepatocytes

1985 • 20 citations

Differentiation of BC₃H1 and primary skeletal muscle cells and the activity of their endogenous insulin‐degrading enzyme are inhibited by the same metalloendoprotease inhibitors

1990 • 18 citations