Characterization of the cation-independent mannose 6-phosphate receptor-enriched prelysosomal compartment in NRK cells

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS

1986 • 1,977 citations

The Biogenesis of Lysosomes

1989 • 1,583 citations

Practical methods for biological morphometry

1979 • 1,498 citations

3-Methyladenine: Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes

1982 • 1,313 citations

The trans Golgi Network: Sorting at the Exit Site of the Golgi Complex

1986 • 1,175 citations

Estimation of surface area from vertical sections

1986 • 1,078 citations

LYSOSOMAL ENZYMES AND THEIR RECEPTORS

1986 • 915 citations

The mannose 6-phosphate receptor and the biogenesis of lysosomes

1988 • 846 citations

ANALYTICAL STUDY OF MICROSOMES AND ISOLATED SUBCELLULAR MEMBRANES FROM RAT LIVER

1974 • 840 citations

Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro.

1989 • 588 citations

Receptor-mediated endocytosis

1985 • 577 citations

Sizing of protein A-colloidal gold probes for immunoelectron microscopy.

1981 • 573 citations

Translocation and clustering of endosomes and lysosomes depends on microtubules.

1987 • 498 citations

Stereological estimation of the volume‐weighted mean volume of arbitrary particles observed on random sections*

1985 • 486 citations

On the preparation of cryosections for immunocytochemistry

1984 • 468 citations

Lysosomes : their role in protein breakdown

1987 • 435 citations

Dissection of the Golgi complex. I. Monensin inhibits the transport of viral membrane proteins from medial to trans Golgi cisternae in baby hamster kidney cells infected with Semliki Forest virus.

1983 • 430 citations

Exit of newly synthesized membrane proteins from the trans cisterna of the Golgi complex to the plasma membrane.

1985 • 415 citations

Two distinct subpopulations of endosomes involved in membrane recycling and transport to lysosomes

1988 • 377 citations

Membrane Traffic in Endocytosis: Insights from Cell-Free Assays

1989 • 369 citations

Two species of lysosomal organelles in cultured human fibroblasts

1979 • 360 citations

A quantitative analysis of the endocytic pathway in baby hamster kidney cells.

1989 • 315 citations

Glycoproteins of the lysosomal membrane.

1985 • 294 citations

Prelysosomal convergence of autophagic and endocytic pathways

1988 • 272 citations

Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis

1989 • 272 citations

Mannose-6-phosphate receptors for lysosomal enzymes cycle between the Golgi complex and endosomes.

1986 • 270 citations

Intracellular movement of two mannose 6-phosphate receptors: return to the Golgi apparatus.

1988 • 263 citations

The entry of enveloped viruses into cells by endocytosis

1984 • 252 citations

Visualization of acidic organelles in intact cells by electron microscopy.

1984 • 250 citations

Cytochemical contributions to differentiating GERL from the Golgi apparatus

1977 • 242 citations

Sorting of mannose 6-phosphate receptors and lysosomal membrane proteins in endocytic vesicles.

1988 • 241 citations

Meeting of the apical and basolateral endocytic pathways of the Madin-Darby canine kidney cell in late endosomes.

1989 • 226 citations

Macrophage endosomes contain proteases which degrade endocytosed protein ligands.

1985 • 223 citations

Cloning and sequence analysis of the cation-independent mannose 6-phosphate receptor.

1988 • 210 citations

The dynamic nature of the Golgi complex.

1989 • 210 citations

Quantitation in immunocytochemistry: correlation of immunogold labeling to absolute number of membrane antigens.

1986 • 195 citations

Selective recycling of the mannose 6-phosphate/IGF-II receptor to the trans Golgi network in vitro

1988 • 177 citations

Biosynthesis and turnover of the mannose 6-phosphate receptor in cultured Chinese hamster ovary cells.

1983 • 169 citations

Lysosomal Enzyme Precursors in Human Fibroblasts. Activation of Cathepsin D Precursor in vitro and Activity of beta-Hexosaminidase A Precursor towards Ganglioside GM2

1982 • 163 citations

Three-dimensional structure of endosomes in BHK-21 cells.

1986 • 162 citations

Cell biology of the secretory process

1984 • 134 citations

Cloning of the bovine 215-kDa cation-independent mannose 6-phosphate receptor.

1987 • 132 citations

Human lysosomal acid phosphatase is transported as a transmembrane protein to lysosomes in transfected baby hamster kidney cells.

1988 • 129 citations

Kinetics and temperature dependence of exposure of endocytosed material to proteolytic enzymes and low pH: Evidence for a maturation model for the formation of lysosomes

1987 • 126 citations

Human lysosomal acid phosphatase: cloning, expression and chromosomal assignment.

1988 • 106 citations

Antibody to mannose 6-phosphate specific receptor induces receptor deficiency in human fibroblasts.

1984 • 104 citations

Endocytosis of cholera toxin into neuronal GERL.

1978 • 101 citations

Transport of surface mannose 6-phosphate receptor to the Golgi complex in cultured human cells

1989 • 77 citations

Reconstitution of an endosome-lysosome interaction in a cell-free system.

1989 • 74 citations

Internalization of blocking antibodies against mannose-6-phosphate specific receptors.

1985 • 68 citations

Limited proteolysis of the beta-hexosaminidase precursor in a cell-free system.

1981 • 64 citations

The endosomal concentration of a mannose 6-phosphate receptor is unchanged in the absence of ligand synthesis.

1987 • 59 citations

Degradation of mucopolysaccharide in intact isolated lysosomes.

1981 • 55 citations

Endolyn-78, a membrane glycoprotein present in morphologically diverse components of the endosomal and lysosomal compartments: implications for lysosome biogenesis.

1989 • 51 citations

Differential and analytical subfraction of rat liver components internalizing insulin and prolactin

1986 • 49 citations

Ultrastructural study of GERL in beige mouse alveolar macrophages.

1977 • 48 citations

Assembly of Lysosomes: Perspectives from Comparative Molecular Cell Biology

1988 • 35 citations

Postendocytic maturation of acid hydrolases: evidence of prelysosomal processing.

1987 • 28 citations