Potential Role of Endosomes in Transmembrane Signaling

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

Functions of Lysosomes

1966 • 2,942 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS

1986 • 1,977 citations

Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System

1985 • 1,585 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

YOLK PROTEIN UPTAKE IN THE OOCYTE OF THE MOSQUITO AEDES AEGYPTI. L

1964 • 1,298 citations

THE LARGE-SCALE SEPARATION OF PEROXISOMES, MITOCHONDRIA, AND LYSOSOMES FROM THE LIVERS OF RATS INJECTED WITH TRITON WR-1339

1968 • 1,112 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

Handbook of molecular cytology

1969 • 1,011 citations

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

Intracellular site of asialoglycoprotein receptor-ligand uncoupling: Double-label immunoelectron microscopy during receptor-mediated endocytosis

1983 • 816 citations

Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts

1977 • 688 citations

Rapid acidification of endocytic vesicles containing α2-macroglobulin

1982 • 672 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

Binding of apotransferrin to K562 cells: explanation of the transferrin cycle.

1983 • 603 citations

Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro.

1989 • 588 citations

Receptor-mediated endocytosis

1985 • 577 citations

Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: Characterization and evidence for receptor recycling

1980 • 574 citations

Phosphorylation activates the insulin receptor tyrosine protein kinase.

1983 • 558 citations

Journey to the Center of the Cell: Role of the Receptosome

1981 • 500 citations

Receptor-mediated endocytosis of transferrin and the uptake of fe in K562 cells: identification of a nonlysosomal acidic compartment.

1982 • 486 citations

The galactose-specific recognition system of mammalian liver: The route of ligand internalization in rat hepatocytes

1980 • 484 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.

1988 • 467 citations

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

1990 • 452 citations

Low temperature selectively inhibits fusion between pinocytic vesicles and lysosomes during heterophagy of 125I-asialofetuin by the perfused rat liver.

1980 • 451 citations

GOLGI FRACTIONS PREPARED FROM RAT LIVER HOMOGENATES

1973 • 449 citations

Movement of internalized ligand–receptor complexes along a continuous endosomal reticulum

1990 • 428 citations

Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase.

1989 • 425 citations

Endosomes

1983 • 416 citations

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

1987 • 403 citations

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.

1987 • 399 citations

The receptosome: An intermediate organelle of receptor-mediated endocytosis in cultured fibroblasts

1980 • 398 citations

Endocytosis and intracellular processing of transferrin and colloidal gold-transferrin in rat reticulocytes: demonstration of a pathway for receptor shedding.

1984 • 397 citations

Two distinct subpopulations of endosomes involved in membrane recycling and transport to lysosomes

1988 • 377 citations

The J. D. mutation in familial hypercholesterolemia: Amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors

1986 • 372 citations

Collection of insulin, EGF and α2-Macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization

1978 • 372 citations

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1988 • 368 citations

The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis.

1987 • 355 citations

A novel mechanism for the insulin-like effect of vanadate on glycogen synthase in rat adipocytes.

1984 • 351 citations

Acidification of macrophage and fibroblast endocytic vesicles in vitro.

1983 • 331 citations

Intracellular routing of transferrin and transferrin receptors in epidermoid carcinoma A431 cells

1983 • 330 citations

A Protein Tyrosine Kinase Involved in Regulation of pp60c-src function

1989 • 309 citations

Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain

1985 • 301 citations

Endosome pH measured in single cells by dual fluorescence flow cytometry: rapid acidification of insulin to pH 6.

1984 • 275 citations

Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis

1989 • 272 citations

Cathepsin D is membrane-associated in macrophage endosomes.

1988 • 259 citations

Proton-Translocating ATPases

1986 • 255 citations

Hormone receptor topology and dynamics: Morphological analysis using ferritin-labeled epidermal growth factor

1979 • 254 citations

A single amino acid change in the cytoplasmic domain allows the influenza virus hemagglutinin to be endocytosed through coated pits

1988 • 245 citations

A possible role for Na+,K+-ATPase in regulating ATP-dependent endosome acidification.

1989 • 229 citations

Regulation of endocytic pH by the Na+,K+-ATPase in living cells.

1989 • 228 citations

Binding and uptake of 125I-insulin into rat liver hepatocytes and endothelium. An in vivo radioautographic study.

1979 • 223 citations

Macrophage endosomes contain proteases which degrade endocytosed protein ligands.

1985 • 223 citations

Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin.

1987 • 221 citations

Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: receptor pathway.

1986 • 217 citations

Coated pits act as molecular filters.

1980 • 208 citations

Rapid analytical and preparative isolation of functional endosomes by free flow electrophoresis

1987 • 208 citations

Internalization of polypeptide hormones

1980 • 207 citations

Deletion of the cytoplasmic domain of the polymeric immunoglobulin receptor prevents basolateral localization and endocytosis

1986 • 202 citations

Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.

1985 • 199 citations

The role of intermediate vesicles in the adsorptive endocytosis and transport of ligand to lysosomes by human fibroblasts.

1983 • 196 citations

Endocytosis of the transferrin receptor requires the cytoplasmic domain but not its phosphorylation site

1987 • 192 citations

OCCURRENCE OF PHAGOSOMES AND PHAGO-LYSOSOMES IN DIFFERENT SEGMENTS OF THE NEPHRON IN RELATION TO THE REABSORPTION, TRANSPORT, DIGESTION, AND EXTRUSION OF INTRAVENOUSLY INJECTED HORSERADISH PEROXIDASE

1964 • 182 citations

Subcellular distribution of a mammalian hepatic binding protein specific for asialoglycoproteins.

1976 • 181 citations

The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation.

1987 • 179 citations

Peroxide(s) of vanadium : A novel and potent insulin-mimetic agent which activates the insulin receptor kinase

1987 • 177 citations

In vitro fusion of endosomes following receptor-mediated endocytosis.

1988 • 175 citations

Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts.

1982 • 171 citations

Intracellular segregation of asialoglycoproteins and their receptor: a prelysosomal event subsequent to dissociation of the ligand-receptor complex.

1984 • 168 citations

Mutations in the cytoplasmic domain of EGF receptor affect EGF binding and receptor internalization.

1986 • 167 citations

Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control.

1988 • 164 citations

Uptake of Insulin and Other Ligands into Receptor-Rich Endocytic Components of Target Cells: The Endosomal Apparatus

1985 • 163 citations

Acidification of endosome subpopulations in wild-type Chinese hamster ovary cells and temperature-sensitive acidification-defective mutants.

1989 • 153 citations

Defective acidification of endosomes in Chinese hamster ovary cell mutants "cross-resistant" to toxins and viruses.

1983 • 153 citations

Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes.

1990 • 151 citations

Stimulation of insulin-like growth factor II receptor binding and insulin receptor kinase activity in rat adipocytes. Effects of vanadate and H2O2.

1987 • 148 citations

Sorting of endocytosed transferrin and asialoglycoprotein occurs immediately after internalization in HepG2 cells.

1987 • 147 citations

Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects.

1988 • 144 citations

Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase.

1986 • 142 citations

The dephosphorylation of insulin and epidermal growth factor receptors. Role of endosome-associated phosphotyrosine phosphatase(s).

1992 • 134 citations

Fusion between endocytic vesicles in a cell-free system.

1987 • 133 citations

Shift of equilibrium density induced by 3,3'-diaminobenzidine cytochemistry: a new procedure for the analysis and purification of peroxidase-containing organelles.

1984 • 132 citations

Morphologic study of the internalization of a lysosomal enzyme by the mannose 6-phosphate receptor in cultured Chinese hamster ovary cells.

1981 • 131 citations

Cleavage of Parathyroid Hormone in Macrophage Endosomes Illustrates a Novel Pathway for Intracellular Processing of Proteins

1989 • 131 citations

Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit.

1990 • 130 citations

Selective iodination and polypeptide composition of pinocytic vesicles.

1980 • 130 citations

Galactose-specific recognition system of mammalian liver: receptor distribution on the hepatocyte cell surface.

1981 • 129 citations

The uptake of prolactin into female rat liver. Concentration of intact hormone in the Golgi apparatus.

1979 • 128 citations

Internalization of functional epidermal growth factor:receptor/kinase complexes in A-431 cells.

1985 • 128 citations

Kinetics and temperature dependence of exposure of endocytosed material to proteolytic enzymes and low pH: Evidence for a maturation model for the formation of lysosomes

1987 • 126 citations

Acidification and Ion Permeabilities of Highly Purified Rat Liver Endosomes

1989 • 123 citations

INSULIN BINDING TO RAT LIVER GOLGI FRACTIONS

1973 • 117 citations

Internalization and Activation of the Rat Liver Insulin Receptor Kinase in vivo

1989 • 116 citations

Uptake of insulin by plasmalemma and Golgi subcellular fractions of rat liver.

1980 • 116 citations

Colloidal gold--low density lipoprotein conjugates as membrane receptor probes.

1981 • 115 citations

Kinetics of endosome acidification detected by mutant and wild-type Semliki Forest virus.

1986 • 115 citations

Relations between the intracellular pathways of the receptors for transferrin, asialoglycoprotein, and mannose 6-phosphate in human hepatoma cells.

1989 • 110 citations

Receptor-mediated endocytosis of asialoglycoproteins by rat liver hepatocytes: biochemical characterization of the endosomal compartments.

1985 • 109 citations

The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth.

1990 • 107 citations

Characterization of rat liver endosomal fractions. In vivo activation of insulin-stimulable receptor kinase in these structures.

1986 • 107 citations

Selective degradation of insulin within rat liver endosomes.

1990 • 106 citations

Effect of chloroquine on the internalization of 125I-insulin into subcellular fractions of rat liver. Evidence for an effect of chloroquine on Golgi elements.

1982 • 102 citations

Ligand-mediated autophosphorylation activity of the epidermal growth factor receptor during internalization.

1989 • 101 citations

Coated vesicles participate in the receptor-mediated endocytosis of insulin.

1983 • 101 citations

Deletions in the cytoplasmic domain of the polymeric immunoglobulin receptor differentially affect endocytotic rate and postendocytotic traffic.

1990 • 100 citations

Isolation of insulin degradation products from endosomes derived from intact rat liver.

1988 • 99 citations

Immunocytochemical localization of the receptor for asialoglycoprotein in rat liver cells.

1982 • 98 citations

Internalization of insulin into rat liver Golgi elements. Evidence for vesicle heterogeneity and the path of intracellular processing.

1982 • 98 citations

Defective internalization of insulin and its receptor in cells expressing mutated insulin receptors lacking kinase activity.

1987 • 97 citations

A domain of the insulin receptor required for endocytosis in rat fibroblasts.

1990 • 97 citations

Insulin activation of insulin receptor tyrosine kinase in intact rat adipocytes. An in vitro system to measure histone kinase activity of insulin receptors activated in vivo.

1986 • 97 citations

Receptor-mediated endocytosis of insulin: role of microvilli, coated pits, and coated vesicles.

1982 • 97 citations

Intracellular pools of transferrin receptors result from constitutive internalization of unoccupied receptors.

1986 • 94 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 does not alter the mitogenic effect of the hormone.

1988 • 92 citations

Endocytosis of Peptide Hormones and Other Ligands

1982 • 90 citations

Polypeptide Hormone Receptors.

1985 • 88 citations

Ligand-mediated internalization, recycling, and downregulation of the epidermal growth factor receptor in vivo.

1989 • 88 citations

The appearance and internalization of transferrin receptors at the margins of spreading human tumor cells

1985 • 82 citations

Epidermal growth factor receptor kinase translocation and activation in vivo.

1986 • 81 citations

Receptor-rich intracellular membrane vesicles transporting asialotransferrin and insulin in liver

1982 • 81 citations

The pathway of the asialoglycoprotein-ligand during receptor-mediated endocytosis: a morphological study with colloidal gold/ligand in the human hepatoma cell line, Hep G2.

1983 • 78 citations

Polypeptide Hormones: Intracellular Receptors and Internalization

1981 • 77 citations

Decrease in beta-subunit phosphotyrosine correlates with internalization and activation of the endosomal insulin receptor kinase.

1992 • 76 citations

Characterization of endocytic compartments using the horseradish peroxidase-diaminobenzidine density shift technique.

1987 • 76 citations

Tyrosine phosphorylation of insulin receptor beta subunit activates the receptor tyrosine kinase in intact H-35 hepatoma cells.

1986 • 75 citations

Reconstitution of an endosome-lysosome interaction in a cell-free system.

1989 • 74 citations

Isolation and characterization of a highly enriched preparation of receptosomes (endosomes) from a human cell line.

1983 • 73 citations

Quantitative ultrastructural analysis of receptor-mediated insulin uptake into adipocytes

1983 • 71 citations

Intracellular processing of epidermal growth factor and its effect on ligand-receptor interactions.

1985 • 71 citations

Subfractionation of hepatic endosomes in Nycodenz gradients and by free-flow electrophoresis. Separation of ligand-transporting and receptor-enriched membranes

1985 • 70 citations

Intracellular hormone receptors: evidence for insulin and lactogen receptors in a unique vesicle sedimenting in lysosome fractions of rat liver.

1981 • 70 citations

An internalized transmembrane protein resides in a fusion-competent endosome for less than 5 minutes.

1987 • 66 citations

Association of the tyrosine phosphorylated epidermal growth factor receptor with a 55-kD tyrosine phosphorylated protein at the cell surface and in endosomes.

1992 • 54 citations

Degradation of endocytosed insulin in rat liver is mediated by low-density vesicles

1985 • 51 citations

Proteolytic processing of epidermal growth factor within endosomes

1987 • 50 citations

The localization in rat liver of alkaline phosphodiesterase to a discrete organelle implicated in ligand internalization

1982 • 49 citations

Polypeptide hormone receptors

1985 • 49 citations

Differential and analytical subfraction of rat liver components internalizing insulin and prolactin

1986 • 49 citations

Cohort movement of different ligands and receptors in the intracellular endocytic pathway of alveolar macrophages

1989 • 45 citations

Galactose‐Specific Endocytosis in Rat Liver

1983 • 40 citations

Co-clustering and internalization of low-density lipoproteins and α2-macroglobulin in human skin fibroblasts

1982 • 40 citations

Effect of colchicine on internalization of prolactin in female rat liver: an in vivo radioautographic study.

1983 • 40 citations

Separation of two populations of endocytic vesicles involved in receptor-ligand sorting in rat hepatocytes.

1986 • 39 citations

Increased phosphorylation of ribosomal protein S6 following microinjection of insulin receptor-kinase into Xenopus oocytes

1986 • 39 citations

In vivo uptake of insulin into hepatic golgi fractions: Application of the diaminobenzidine-shift protocol

1984 • 37 citations

Radioautographic Visualization of in Vivo Insulin Binding to the Exocrine Pancreas*

1980 • 35 citations

Binding and Uptake of [¹²⁵I]Iodoprolactin by Epithelial Cells of the Rat Choroid Plexus: Anin VivoAutoradiographic Analysis*

1984 • 35 citations

Preparation of a low-density species of endocytic vesicle containing immunoglobulin A

1983 • 34 citations

Structure and function of tyrosine kinase receptors

1991 • 32 citations

In Vitro Clustering and Multiple Fusion among Macrophage Endosomes

1989 • 32 citations

Isolation of an endocytic compartment from A431 cells using a density modification procedure employing a receptor-specific monoclonal antibody complexed with colloidal gold

1987 • 32 citations

Insulin and Insulin Receptor Uptake into Rat Liver: Chloroquine Action on Receptor Recycling

1985 • 29 citations

Interactions of cholera toxin with isolated hepatocytes. Effects of low pH, chloroquine and monensin on toxin internalization, processing and action

1988 • 27 citations

Separation of endocytic vesicles in Nycodenz gradients

1984 • 27 citations

Rapid cell surface appearance of endocytic membrane proteins in Chinese hamster ovary cells.

1981 • 26 citations

Polymeric IgA and Galactose-Specific Pathways in Rat Hepatocytes: Evidence for Intracellular Ligand Sorting

1985 • 22 citations

In situ 125I-labelling of endosome proteins with lactoperoxidase conjugates.

1984 • 21 citations

Coordinate Phosphorylation of Insulin-Receptor Kinase and Its 175,000-Mr Endogenous Substrate in Rat Hepatocytes

1991 • 20 citations

The preparative isolation of endosome fractions: A review

1987 • 18 citations

Prolactin uptake into liver endocytic components. Reduced sensitivity to chloroquine

1985 • 14 citations

Differential kinetics and sensitivity to chloroquine of receptor-mediated insulin and prolactin endocytosis in liver parenchymal cells

1986 • 9 citations

Redistribution of cell surface transferrin receptors prior to their concentration in coated pits as revealed by immunoferritin labels

1986 • 4 citations

Internalization of Insulin and Its Receptor: Role in Signaling

1987 • 3 citations