An essential role for HLA–DM in antigen presentation by class II major histocompatibility molecules

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

Two populations of Ia-like molecules on a human B cell line.

1980 • 1,112 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway

1990 • 644 citations

Map of the human MHC

1993 • 585 citations

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

1992 • 380 citations

MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

1992 • 368 citations

Evidence for a new segregant series of B cell antigens that are encoded in the HLA-D region and that stimulate secondary allogenic proliferative and cytotoxic responses.

1980 • 348 citations

Identification of a CD4 binding site on the β2 domain of HLA-DR molecules

1992 • 272 citations

A new human HLA class II-related locus, DM

1991 • 251 citations

Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes

1990 • 236 citations

Invariant Chain Peptides in Most HLA-DR Molecules of an Antigen-Processing Mutant

1992 • 218 citations

Immunobiology of HLA

1989 • 175 citations

New class ll-like genes in the murine MHC

1991 • 129 citations

The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.

1992 • 125 citations

Stable variants affecting B cell alloantigens in human lymphoid cells

1978 • 109 citations

A gene required for class II-restricted antigen presentation maps to the major histocompatibility complex.

1991 • 106 citations

A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides.

1994 • 91 citations

Direct demonstration of an HLA-DR allotypic determinant on the low molecular weight (beta) subunit using a mouse monoclonal antibody specific for DR3

1982 • 83 citations

MHC class II deletion mutant expresses normal levels of transgene encoded class II molecules that have abnormal conformation and impaired antigen presentation ability.

1992 • 72 citations

Gene dosage and gene expression in the HLA region: Evidence from deletion variants

1982 • 66 citations

HLA class II regulation and structure. Analysis with HLA-DR3 and HLA-DP point mutants.

1985 • 60 citations

Structural mutation affecting intracellular transport and cell surface expression of murine class II molecules.

1988 • 51 citations

Importance of HLA-DQ and -DP restriction elements in T-cell responses to soluble antigens: Mutational analysis

1987 • 39 citations