Proteolytic cleavage of ricin A chain in endosomal vesicles. Evidence for the action of endosomal proteases at both neutral and acidic pH.

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY

1963 • 10,322 citations

Coated pits, coated vesicles, and receptor-mediated endocytosis

1979 • 2,073 citations

THE ENZYMATIC IODINATION OF THE RED CELL MEMBRANE

1972 • 709 citations

Rapid acidification of endocytic vesicles containing α2-macroglobulin

1982 • 672 citations

Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: Characterization and evidence for receptor recycling

1980 • 574 citations

Proteinases in Mammalian Cells and Tissues

1977 • 537 citations

Two distinct subpopulations of endosomes involved in membrane recycling and transport to lysosomes

1988 • 377 citations

Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment

1990 • 377 citations

2-Imino-2-methoxyethyl 1-thioglycosides: new reagents for attaching sugars to proteins

1976 • 334 citations

Rapid entry of nicked diphtheria toxin into cells at low pH. Characterization of the entry process and effects of low pH on the toxin molecule.

1981 • 291 citations

Cathepsin D is membrane-associated in macrophage endosomes.

1988 • 259 citations

The entry of enveloped viruses into cells by endocytosis

1984 • 252 citations

Internalization and degradation of macrophage Fc receptors bound to polyvalent immune complexes.

1984 • 250 citations

Intracellular movement of cell surface receptors after endocytosis: resialylation of asialo-transferrin receptor in human erythroleukemia cells.

1985 • 229 citations

Macrophage endosomes contain proteases which degrade endocytosed protein ligands.

1985 • 223 citations

Inhibitory Effect of di- and Tripeptidyl Aldehydes on Calpains and Cathepsins

1990 • 204 citations

In vitro fusion of endosomes following receptor-mediated endocytosis.

1988 • 175 citations

Mannose receptor-mediated uptake of ricin toxin and ricin A chain by macrophages. Multiple intracellular pathways for a chain translocation.

1986 • 167 citations

The specificity of cathepsin B. Hydrolysis of glucagon at the C-terminus by a peptidyldipeptidase mechanism

1978 • 159 citations

Identification of proteases that process distinct epitopes on the same protein.

1989 • 147 citations

Cleavage of Parathyroid Hormone in Macrophage Endosomes Illustrates a Novel Pathway for Intracellular Processing of Proteins

1989 • 131 citations

[66b] Bovine trypsin-kallikrein inhibitor (kunits inhibitor, basic pancreatic trypsin inhibitor, polyvalent inhibitor from bovine organs)

1970 • 126 citations

Kinetics and temperature dependence of exposure of endocytosed material to proteolytic enzymes and low pH: Evidence for a maturation model for the formation of lysosomes

1987 • 126 citations

Different roles for thiol and aspartyl proteases in antigen presentation of ovalbumin.

1990 • 113 citations

Selective degradation of insulin within rat liver endosomes.

1990 • 106 citations

Requirement for metalloendoprotease in exocytosis: Evidence in mast cells and adrenal chromaffin cells

1985 • 100 citations

Ricin A-chain containing immunotoxins directed against different epitopes on the CD2 molecule differ in their ability to kill normal and malignant T cells.

1988 • 95 citations

Immunotoxins--entry into cells and mechanisms of action.

1989 • 95 citations

The identification of active forms of cysteine proteinases in Kirsten-virus-transformed mouse fibroblasts by use of a specific radiolabelled inhibitor

1989 • 86 citations

Endocytosis, intracellular trafficking, and processing of membrane IgG and monovalent antigen/membrane IgG complexes in B lymphocytes.

1990 • 85 citations

Purification of cathepsin B by a new form of affinity chromatography

1986 • 83 citations

Dissociation of ionizing groups in the binding cleft inversely controls the endo- and exopeptidase activities of cathepsin B.

1987 • 72 citations

Active center differences between cathepsins L and B: The S₁ binding region

1988 • 66 citations

Generation of Macrophage Variants With 5-Azacytidine: Selection for Mannose Receptor Expression

1987 • 62 citations

By-product analogs for bovine carboxypeptidase B

1978 • 54 citations

Proteolytic processing of epidermal growth factor within endosomes

1987 • 50 citations

Stabilisation of cathepsin E by ATP

1989 • 34 citations

Chapter 2 Digitonin Permeabilization Procedures for the Study of Endosome Acidification and Function

1989 • 30 citations

Immunolocalization of Endosomal Cathepsin D in Rabbit Alveolar Macrophages

1990 • 20 citations

Proteolytic Processing in Endosomal Vesicles

1989 • 17 citations