Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

1988 • 1,161 citations

Association of class I major histocompatibility heavy and light chains induced by viral peptides

1989 • 995 citations

Empty MHC class I molecules come out in the cold

1990 • 933 citations

Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb molecule

1990 • 689 citations

Use of a Monoclonal Antibody (W6/32) in Structural Studies of HLA-A,B,C Antigens

1979 • 682 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

Differences in antigen presentation to MHC class I-and class II-restricted influenza virus-specific cytolytic T lymphocyte clones.

1986 • 513 citations

Assembly of MHC class I molecules analyzed in vitro

1990 • 491 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

1990 • 445 citations

Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro

1990 • 418 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

Role for intracellular proteases in the processing and transport of class II HLA antigens.

1988 • 336 citations

Antigen Presentation Pathways to Class I and Class II MHC‐Restricted T Lymphocytes

1987 • 322 citations

A role for peptide in determining MHC class II structure

1991 • 275 citations

Cell-free synthesis and membrane insertion of mouse H-2Dd histocompatibility antigen and β2-microglobulin

1979 • 274 citations

Identification of naturally processed viral nonapeptides allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast.

1991 • 266 citations

Peptide selection by MHC class I molecules

1991 • 253 citations

Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes

1990 • 236 citations

Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.

1991 • 234 citations

Allele and locus‐specific differences in cell surface expression and the association of HLA class I heavy chain with β₂‐microglobulin: differential effects of inhibition of glycosylation on class I subunit association

1988 • 224 citations

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.

1992 • 219 citations

Structural model of HLA-DR1 restricted T cell antigen recognition

1988 • 172 citations

An improved biochemical method for the analysis of HLA-class I antigens. Definition of new HLA-class I subtypes

1986 • 167 citations

Autologous Peptides Constitutively Occupy the Antigen Binding Site on Ia

1988 • 157 citations

Expression of a class II major histocompatibility complex (MHC) heterodimer in a lipid-linked form with enhanced peptide/soluble MHC complex formation at low pH.

1991 • 143 citations

Characterization of a naturally processed MHC class II-restricted T-cell determinant of hen egg lysozyme

1989 • 111 citations

Specificity of monoclonal antibodies directed against human and murine class II histocompatibility antigens as analyzed by binding to HLA-deletion mutant cell lines

1985 • 106 citations

Purification of HLA-linked B lymphocyte alloantigens in immunologically active form by preparative sodium dodecyl sulfate-gel electrophoresis and studies on their subunit association.

1977 • 79 citations

Inhibition by leupeptin and antipain of the intracellular proteolysis of Ii

1989 • 66 citations

Isolation and Characterization of Human B Cell Alloantigens

1976 • 52 citations

Structure of Ia antigens: identification of dimeric complexes formed by the invariant chain.

1982 • 40 citations

Assembly and intracellular transport of major histocompatibility complex molecules

1991 • 36 citations

Human B cell alloantigens: separation from other membrane molecules by affinity chromatography

1977 • 33 citations

Clonal sketches of the immune response.

1988 • 28 citations