Regulation of the APC and the exit from mitosis

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors

1997 • 2,201 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

UBIQUITIN-DEPENDENT PROTEIN DEGRADATION

1996 • 1,680 citations

Robustness in simple biochemical networks

1997 • 1,531 citations

How Proteolysis Drives the Cell Cycle

1996 • 1,277 citations

Robustness in bacterial chemotaxis

1999 • 1,147 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

1995 • 964 citations

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.

1991 • 858 citations

CDC20 and CDH1 : A Family of Substrate-Specific Activators of APC-Dependent Proteolysis

1997 • 809 citations

Association of Spindle Assembly Checkpoint Component XMAD2 with Unattached Kinetochores

1996 • 785 citations

Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.

1996 • 777 citations

Mitosis in transition

1994 • 745 citations

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

1995 • 745 citations

The Phosphatase Cdc14 Triggers Mitotic Exit by Reversal of Cdk-Dependent Phosphorylation

1998 • 744 citations

Exit from Mitosis Is Triggered by Tem1-Dependent Release of the Protein Phosphatase Cdc14 from Nucleolar RENT Complex

1999 • 720 citations

Temporal and spatial control of cyclin B1 destruction in metaphase

1999 • 685 citations

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.

1996 • 685 citations

An ESP1/PDS1 Complex Regulates Loss of Sister Chromatid Cohesion at the Metaphase to Anaphase Transition in Yeast

1998 • 594 citations

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

1998 • 590 citations

Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor

1993 • 569 citations

Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus

1999 • 566 citations

Genes involved in sister chromatid separation are needed for b-type cyclin proteolysis in budding yeast

1995 • 561 citations

Budding Yeast Cdc20: A Target of the Spindle Checkpoint

1998 • 561 citations

Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles

1988 • 546 citations

Kinetochore Localization of Murine Bub1 Is Required for Normal Mitotic Timing and Checkpoint Response to Spindle Damage

1997 • 543 citations

Control of Cyclin Ubiquitination by CDK-Regulated Binding of Hct1 to the Anaphase Promoting Complex

1998 • 521 citations

The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SW15

1991 • 501 citations

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae

1998 • 488 citations

Direct Binding of CDC20 Protein Family Members Activates the Anaphase-Promoting Complex in Mitosis and G1

1998 • 484 citations

Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast.

1993 • 483 citations

Yeast Hct1 Is a Regulator of Clb2 Cyclin Proteolysis

1997 • 479 citations

Localization of Mad2 to Kinetochores Depends on Microtubule Attachment, Not Tension

1998 • 475 citations

Phosphorylation of Sic1p by G ₁ Cdk Required for Its Degradation and Entry into S Phase

1997 • 454 citations

Cut2 proteolysis required for sister-chromatid separation in fission yeast

1996 • 451 citations

Drosophila fizzy-related Down-Regulates Mitotic Cyclins and Is Required for Cell Proliferation Arrest and Entry into Endocycles

1997 • 421 citations

Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14

1999 • 417 citations

Four-dimensional control of the cell cycle

1999 • 386 citations

Net1, a Sir2-Associated Nucleolar Protein Required for rDNA Silencing and Nucleolar Integrity

1999 • 383 citations

Fission Yeast Slp1: An Effector of the Mad2-Dependent Spindle Checkpoint

1998 • 381 citations

The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle.

1990 • 377 citations

The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.

1995 • 376 citations

CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition

1995 • 369 citations

The spindle assembly checkpoint

1996 • 364 citations

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).

1996 • 357 citations

Polo-like kinases: positive regulators of cell division from start to finish

1998 • 346 citations

Mass Spectrometric Analysis of the Anaphase-Promoting Complex from Yeast: Identification of a Subunit Related to Cullins

1998 • 330 citations

PKA and MPF-Activated Polo-like Kinase Regulate Anaphase-Promoting Complex Activity and Mitosis Progression

1998 • 309 citations

A Late Mitotic Regulatory Network Controlling Cyclin Destruction inSaccharomyces cerevisiae

1998 • 305 citations

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells

1992 • 298 citations

Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3.

1995 • 286 citations

SCF and APC: the Yin and Yang of cell cycle regulated proteolysis

1998 • 271 citations

The decision to enter mitosis

1994 • 270 citations

A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5.

1993 • 270 citations

Identification of Subunits of the Anaphase-Promoting Complex of Saccharomyces cerevisiae

1996 • 263 citations

Identification of a Cullin Homology Region in a Subunit of the Anaphase-Promoting Complex

1998 • 253 citations

The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae

1998 • 244 citations

Mammalian p55CDC Mediates Association of the Spindle Checkpoint Protein Mad2 with the Cyclosome/Anaphase-promoting Complex, and is Involved in Regulating Anaphase Onset and Late Mitotic Events

1998 • 240 citations

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

1997 • 236 citations

The regulation of Cdc20 proteolysis reveals a role for the APC components Cdc23 and Cdc27 during S phase and early mitosis

1998 • 235 citations

The disappearance of cyclin B at the end of mitosis is regulated spatially in Drosophila cells

1999 • 233 citations

Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase

1990 • 222 citations

Microinjection of Antibody to Mad2 Protein into Mammalian Cells in Mitosis Induces Premature Anaphase

1998 • 215 citations

The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts

1998 • 214 citations

Drosophila Polo Kinase Is Required for Cytokinesis

1998 • 203 citations

Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase.

1995 • 201 citations

Identification of BIME as a Subunit of the Anaphase-Promoting Complex

1996 • 200 citations

Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts

1998 • 196 citations

Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes.

1996 • 189 citations

The yeast TEM1 gene, which encodes a GTP-binding protein, is involved in termination of M phase.

1994 • 187 citations

Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage

1999 • 184 citations

The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae.

1995 • 180 citations

Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family

1998 • 178 citations

MOB1, an Essential Yeast Gene Required for Completion of Mitosis and Maintenance of Ploidy

1998 • 166 citations

The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway

1997 • 157 citations

Cdc20 is essential for the cyclosome-mediated proteolysis of both Pds1 and Clb2 during M phase in budding yeast

1998 • 152 citations

Exit from mitosis inDrosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation

1998 • 145 citations

Xe-p9, a Xenopus Suc1/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase- promoting complex at mitosis

1998 • 139 citations

Bifurcation of the mitotic checkpoint pathway in budding yeast

1999 • 133 citations

The Transcription Factor Swi5 Regulates Expression of the Cyclin Kinase Inhibitor p40^SIC1

1996 • 131 citations

Cell Cycle-regulated Expression, Phosphorylation, and Degradation of p55Cdc

1997 • 125 citations

The product of the Saccharomyces cerevisiae cell cycle gene DBF2 has homology with protein kinases and is periodically expressed in the cell cycle.

1990 • 124 citations

Proteolytic ratchets that control progression through mitosis

1998 • 122 citations

The Activity of Cdc14p, an Oligomeric Dual Specificity Protein Phosphatase from Saccharomyces cerevisiae, Is Required for Cell Cycle Progression

1997 • 119 citations

Cut1 is loaded onto the spindle by binding to Cut2 and promotes anaphase spindle movement upon Cut2 proteolysis

1998 • 118 citations

A Bub2p-dependent spindle checkpoint pathway regulates the Dbf2p kinase in budding yeast

1999 • 115 citations

The Swi5 Transcription Factor of Saccharomyces cerevisiae Has a Role in Exit From Mitosis Through Induction of the cdk-Inhibitor Sic1 in Telophase

1997 • 114 citations

The spindle checkpoint

1998 • 113 citations

TPR proteins required for anaphase progression mediate ubiquitination of mitotic B-type cyclins in yeast.

1996 • 112 citations

Fission Yeast Ste9, a Homolog of Hct1/Cdh1 and Fizzy-related, Is a Novel Negative Regulator of Cell Cycle Progression during G₁-Phase

1998 • 108 citations

CDC15, an essential cell cycle gene in Saccharomyces cerevisiae, encodes a protein kinased domain

1991 • 107 citations

CDC14 of Saccharomyces cerevisiae. Cloning, sequence analysis, and transcription during the cell cycle.

1992 • 99 citations

A WD Repeat Protein Controls the Cell Cycle and Differentiation by Negatively Regulating Cdc2/B-Type Cyclin Complexes

1997 • 97 citations

Eliminating All Obstacles: Regulated Proteolysis in the Eukaryotic Cell Cycle

1997 • 94 citations

Characterization of the DOC1/APC10 Subunit of the Yeast and the Human Anaphase-promoting Complex

1999 • 94 citations

Isolation of a CDC25 family gene, MSI2/LTE1, as a multicopy suppressor of ira1

1994 • 94 citations

Regulation of B-type cyclin proteolysis by Cdc28-associated kinases in budding yeast

1997 • 86 citations

A Novel Yeast Screen for Mitotic Arrest Mutants IdentifiesDOC1, a New Gene Involved in Cyclin Proteolysis

1997 • 85 citations

A Subunit of the Anaphase-Promoting Complex Is a Centromere-Associated Protein in Mammalian Cells

1998 • 63 citations

Budding yeast RSI1/APC2, a novel gene necessary for initiation of anaphase, encodes an APC subunit

1998 • 53 citations

Expression of N-terminally truncated cyclin B in the Drosophila larval brain leads to mitotic delay at late anaphase

1994 • 52 citations

Dominant mutant alleles of yeast protein kinase geneCDC15 suppress thelte1 defect in termination of M phase and genetically interact withCDC14

1996 • 46 citations