The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

Guide to Yeast Genetics and Molecular Biology

1993 • 2,377 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors

1997 • 2,201 citations

UBIQUITIN-DEPENDENT PROTEIN DEGRADATION

1996 • 1,680 citations

How Proteolysis Drives the Cell Cycle

1996 • 1,277 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

1995 • 964 citations

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

1994 • 902 citations

CDC20 and CDH1 : A Family of Substrate-Specific Activators of APC-Dependent Proteolysis

1997 • 809 citations

Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.

1996 • 777 citations

Mitosis in transition

1994 • 745 citations

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

1995 • 745 citations

GENETIC CONTROL OF THE CELL DIVISION CYCLE IN YEAST: V. GENETIC ANALYSIS OF cdc MUTANTS

1973 • 728 citations

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.

1996 • 685 citations

GFP tagging of budding yeast chromosomes reveals that protein–protein interactions can mediate sister chromatid cohesion

1996 • 589 citations

Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor

1993 • 569 citations

Genes involved in sister chromatid separation are needed for b-type cyclin proteolysis in budding yeast

1995 • 561 citations

Budding Yeast Cdc20: A Target of the Spindle Checkpoint

1998 • 561 citations

Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles

1988 • 546 citations

Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts

1996 • 506 citations

Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast.

1993 • 483 citations

Yeast Hct1 Is a Regulator of Clb2 Cyclin Proteolysis

1997 • 479 citations

Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle

1994 • 478 citations

Cut2 proteolysis required for sister-chromatid separation in fission yeast

1996 • 451 citations

CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint

1997 • 433 citations

Drosophila fizzy-related Down-Regulates Mitotic Cyclins and Is Required for Cell Proliferation Arrest and Entry into Endocycles

1997 • 421 citations

Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex

1994 • 393 citations

Fission Yeast Slp1: An Effector of the Mad2-Dependent Spindle Checkpoint

1998 • 381 citations

The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.

1995 • 376 citations

S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state

1995 • 366 citations

Methods in enzymology vol 194 guide to yeast genetics and molecular biology

1991 • 359 citations

Use of polymerase chain reaction epitope tagging for protein tagging in Saccharomyces cerevisiae

1995 • 316 citations

Cyclin Ubiquitination: The destructive end of mitosis

1995 • 304 citations

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells

1992 • 298 citations

Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates.

1996 • 288 citations

Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3.

1995 • 286 citations

The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase.

1996 • 283 citations

The decision to enter mitosis

1994 • 270 citations

A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5.

1993 • 270 citations

Identification of Subunits of the Anaphase-Promoting Complex of Saccharomyces cerevisiae

1996 • 263 citations

APC-Mediated Proteolysis of Ase1 and the Morphogenesis of the Mitotic Spindle

1997 • 243 citations

Cdc16p, Cdc23p and Cdc27p form a complex essential for mitosis.

1994 • 243 citations

An Inhibitor of p34 ^CDC28 Protein Kinase Activity from Saccharomyces cerevisiae

1993 • 236 citations

Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2.

1994 • 235 citations

Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase

1990 • 222 citations

Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase.

1995 • 201 citations

Identification of BIME as a Subunit of the Anaphase-Promoting Complex

1996 • 200 citations

p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase

1995 • 190 citations

The yeast TEM1 gene, which encodes a GTP-binding protein, is involved in termination of M phase.

1994 • 187 citations

Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast

1996 • 185 citations

The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe.

1996 • 162 citations

20S cyclosome complex formation and proteolytic activity inhibited by the cAMP/PKA pathway

1996 • 162 citations

Requirement for cAMP-PKA Pathway Activation by M Phase-Promoting Factor in the Transition from Mitosis to Interphase

1996 • 137 citations

Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins.

1995 • 134 citations

The product of the Saccharomyces cerevisiae cell cycle gene DBF2 has homology with protein kinases and is periodically expressed in the cell cycle.

1990 • 124 citations

The Swi5 Transcription Factor of Saccharomyces cerevisiae Has a Role in Exit From Mitosis Through Induction of the cdk-Inhibitor Sic1 in Telophase

1997 • 114 citations

Human Prk Is a Conserved Protein Serine/Threonine Kinase Involved in Regulating M Phase Functions

1997 • 112 citations

TPR proteins required for anaphase progression mediate ubiquitination of mitotic B-type cyclins in yeast.

1996 • 112 citations

CDC15, an essential cell cycle gene in Saccharomyces cerevisiae, encodes a protein kinased domain

1991 • 107 citations

CDC14 of Saccharomyces cerevisiae. Cloning, sequence analysis, and transcription during the cell cycle.

1992 • 99 citations

Polo kinase: the choreographer of the mitotic stage?

1996 • 97 citations

Eliminating All Obstacles: Regulated Proteolysis in the Eukaryotic Cell Cycle

1997 • 94 citations

A Novel Role for Cdc5p in DNA Replication

1996 • 94 citations

Tertiary structures of class I ubiquitin-conjugating enzymes are highly conserved: Crystal structure of yeast Ubc4

1993 • 91 citations

Regulation of B-type cyclin proteolysis by Cdc28-associated kinases in budding yeast

1997 • 86 citations

A Novel Yeast Screen for Mitotic Arrest Mutants IdentifiesDOC1, a New Gene Involved in Cyclin Proteolysis

1997 • 85 citations

Expression of N-terminally truncated cyclin B in the Drosophila larval brain leads to mitotic delay at late anaphase

1994 • 52 citations