The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae.

Basic local alignment search tool

1990 • 87,358 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

Transposition of Cloned P Elements into Drosophila Germ Line Chromosomes

1982 • 1,560 citations

Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes

1971 • 1,553 citations

A stable genomic source of P element transposase in Drosophila melanogaster.

1988 • 1,359 citations

ANIMAL CELL CYCLES AND THEIR CONTROL

1992 • 1,239 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

Feedback control of mitosis in budding yeast

1991 • 1,167 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

1991 • 1,125 citations

Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+

1988 • 885 citations

The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis

1988 • 829 citations

Dominoes and Clocks: the Union of Two Views of the Cell Cycle

1989 • 750 citations

Creative blocks: cell-cycle checkpoints and feedback controls

1992 • 686 citations

One-step transformation of yeast in stationary phase

1992 • 683 citations

cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF

1989 • 666 citations

Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor

1993 • 569 citations

Genetic control of cell division patterns in the Drosophila embryo

1989 • 567 citations

MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B.

1989 • 550 citations

A family of yeast expression vectors containing the phage f1 intergenic region1

1987 • 514 citations

Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast.

1993 • 483 citations

The TPR snap helix: a novel protein repeat motif from mitosis to transcription

1991 • 452 citations

The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string

1990 • 434 citations

S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase

1993 • 422 citations

Duplication of Spindle Plaques and Integration of the Yeast Cell Cycle

1974 • 419 citations

ALTERED FIDELITY OF MITOTIC CHROMOSOME TRANSMISSION IN CELL CYCLE MUTANTS OF S. CEREVISIAE

1985 • 390 citations

The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle.

1990 • 377 citations

Parameters controlling transcriptional activation during early drosophila development

1986 • 377 citations

A cyclin B homolog in S. cerevisiae: Chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis

1991 • 310 citations

Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis.

1994 • 301 citations

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells

1992 • 298 citations

slit: An EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system

1988 • 281 citations

The A- and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transition.

1990 • 262 citations

The regulation of the cell cycle during Drosophila embryogenesis: the transition to polyteny

1991 • 259 citations

Preferential transposition of Drosophila P elements to nearby chromosomal sites.

1993 • 253 citations

Neurogenesis of the peripheral nervous system in Drosophila embryos: DNA replication patterns and cell lineages

1989 • 248 citations

Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts.

1991 • 246 citations

Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit

1993 • 244 citations

cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates

1992 • 243 citations

The WD‐40 repeat

1992 • 241 citations

Targets of cyclin-dependent protein kinases

1993 • 240 citations

The origin of postembryonic neuroblasts in the ventral nerve cord of Drosophila melanogaster

1991 • 239 citations

The requirements for protein synthesis and degradation, and the control of destruction of cyclins A and B in the meiotic and mitotic cell cycles of the clam embryo.

1992 • 236 citations

Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins

1992 • 230 citations

twine, a cdc25 homolog that functions in the male and female germline of drosophila

1992 • 205 citations

Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M-phase, but only cyclin B delta 97 turns on cyclin destruction.

1991 • 196 citations

Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant.

1990 • 178 citations

The notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuronal precursor cells during Drosophila development.

1989 • 150 citations

Complementation of fission yeast cdc2ts and cdc25ts mutants identifies two cell cycle genes from Drosophila: a cdc2 homologue and string.

1990 • 139 citations

Control of programmed cyclin destruction in a cell-free system.

1989 • 138 citations

A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4.

1994 • 120 citations

The substrates of the cdc2 kinase.

1991 • 115 citations

The CDC20 Gene Product of Saccharomyces cerevisiae, a β-Transducin Homolog, Is Required for a Subset of Microtubule-Dependent Cellular Processes

1991 • 106 citations

Ubiquitin-dependent protein degradation: a cellular perspective

1992 • 96 citations

The dynamics of chromosome movement in the budding yeast Saccharomyces cerevisiae.

1989 • 86 citations

The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. VII. Characterization of the region around the snail and cactus loci.

1990 • 83 citations

Cyclins A and B associate with chromatin and the polar regions of spindles, respectively, and do not undergo complete degradation at anaphase in syncytial Drosophila embryos.

1992 • 71 citations

Mutations of the fizzy locus cause metaphase arrest in Drosophila melanogaster embryos

1993 • 59 citations

Mitotic arrest caused by the amino terminus of Xenopus cyclin B2.

1993 • 48 citations

A Novel Mammalian Protein, p55CDC, Present in Dividing Cells Is Associated with Protein Kinase Activity and Has Homology to the Saccharomyces cerevisiae Cell Division Cycle Proteins Cdc20 and Cdc4

1994 • 44 citations

The substrates of the cdc2 kinase.

1991 • 38 citations

Mutations in the Drosophila melanogaster gene three rows permit aspects of mitosis to continue in the absence of chromatid segregation

1993 • 34 citations

Cloning and expression of antigenic epitopes of the human 68-kDa (U1) ribonucleoprotein antigen in Escherichia coli.

1991 • 17 citations