Drosophila fizzy-related Down-Regulates Mitotic Cyclins and Is Required for Cell Proliferation Arrest and Entry into Endocycles

A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

1989 • 2,555 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

1984 • 1,546 citations

The ancient regulatory-protein family of WD-repeat proteins

1994 • 1,478 citations

The 2.0 Å crystal structure of a heterotrimeric G protein

1996 • 1,118 citations

The structure of the G protein heterotrimer Giα1β1γ2

1995 • 1,091 citations

A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

1995 • 964 citations

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

1994 • 902 citations

Functional cDNA libraries from Drosophila embryos

1988 • 604 citations

Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor

1993 • 569 citations

Two steps in the assembly of complexes at yeast replication origins in vivo

1994 • 566 citations

Genes involved in sister chromatid separation are needed for b-type cyclin proteolysis in budding yeast

1995 • 561 citations

Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation

1994 • 543 citations

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster

1984 • 538 citations

CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae.

1993 • 521 citations

Yeast Hct1 Is a Regulator of Clb2 Cyclin Proteolysis

1997 • 479 citations

Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle

1994 • 478 citations

Cut2 proteolysis required for sister-chromatid separation in fission yeast

1996 • 451 citations

cul-1 Is Required for Cell Cycle Exit in C. elegans and Identifies a Novel Gene Family

1996 • 448 citations

The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string

1990 • 434 citations

The roles of Drosophila cyclins A and B in mitotic control

1990 • 429 citations

Cdk inhibitors in development and cancer

1996 • 410 citations

Expression and function of Drosophila cyclin a during embryonic cell cycle progression

1989 • 399 citations

Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex

1994 • 393 citations

CLB5: a novel B cyclin from budding yeast with a role in S phase.

1992 • 391 citations

Developmental Control of Cell Cycle Regulators: A Fly's Perspective

1996 • 383 citations

S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state

1995 • 366 citations

An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast

1996 • 362 citations

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).

1996 • 357 citations

Dacapo, a Cyclin-Dependent Kinase Inhibitor, Stops Cell Proliferation during Drosophila Development

1996 • 319 citations

A Cyclin-Dependent Kinase Inhibitor, Dacapo, Is Necessary for Timely Exit from the Cell Cycle during Drosophila Embryogenesis

1996 • 314 citations

Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3.

1995 • 286 citations

Cell Cycle Control of DNA Replication by a Homologue from Human Cells of the p34 ^cdc2 Protein Kinase

1990 • 285 citations

A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins.

1996 • 285 citations

The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase.

1996 • 283 citations

Identification of Subunits of the Anaphase-Promoting Complex of Saccharomyces cerevisiae

1996 • 263 citations

The regulation of the cell cycle during Drosophila embryogenesis: the transition to polyteny

1991 • 259 citations

Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis.

1995 • 220 citations

Identification of BIME as a Subunit of the Anaphase-Promoting Complex

1996 • 200 citations

p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase

1995 • 190 citations

The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae.

1995 • 180 citations

A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4.

1994 • 120 citations

The spindle-assembly checkpoint: aiming for a perfect mitosis, every time

1996 • 119 citations

A group of genes required for maintenance of the amnioserosa tissue in Drosophila

1996 • 110 citations

Regulating S Phase: CDKs, Licensing and Proteolysis

1996 • 109 citations

A Cdc2 dependent checkpoint maintains diploidy in Drosophila

1996 • 97 citations

Cell Cycle-Regulated Transcription of the CLB2 Gene Is Dependent on Mcm1 and a Ternary Complex Factor

1995 • 95 citations

roughex down-regulates G2 cyclins in G1.

1997 • 73 citations

Mutations of the fizzy locus cause metaphase arrest in Drosophila melanogaster embryos

1993 • 59 citations

G2 cyclins are required for the degradation of G1 cyclins in yeast

1996 • 46 citations

xlgv7: a maternal gene product localized in nuclei of the central nervous system in Xenopus laevis.

1989 • 38 citations

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