Mammalian p55CDC Mediates Association of the Spindle Checkpoint Protein Mad2 with the Cyclosome/Anaphase-promoting Complex, and is Involved in Regulating Anaphase Onset and Late Mitotic Events

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Cohesins: Chromosomal Proteins that Prevent Premature Separation of Sister Chromatids

1997 • 1,466 citations

A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

1995 • 964 citations

A Direct Link between Sister Chromatid Cohesion and Chromosome Condensation Revealed through the Analysis of MCD1 in S. cerevisiae

1997 • 829 citations

CDC20 and CDH1 : A Family of Substrate-Specific Activators of APC-Dependent Proteolysis

1997 • 809 citations

Association of Spindle Assembly Checkpoint Component XMAD2 with Unattached Kinetochores

1996 • 785 citations

Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.

1996 • 777 citations

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

1995 • 745 citations

The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores.

1995 • 701 citations

How Cells Get the Right Chromosomes

1997 • 625 citations

Identification of a Human Mitotic Checkpoint Gene: hsMAD2

1996 • 609 citations

Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor

1993 • 569 citations

Genes involved in sister chromatid separation are needed for b-type cyclin proteolysis in budding yeast

1995 • 561 citations

Budding Yeast Cdc20: A Target of the Spindle Checkpoint

1998 • 561 citations

Kinetochore Localization of Murine Bub1 Is Required for Normal Mitotic Timing and Checkpoint Response to Spindle Damage

1997 • 543 citations

Mitotic forces control a cell-cycle checkpoint

1995 • 535 citations

Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle.

1994 • 511 citations

Yeast Hct1 Is a Regulator of Clb2 Cyclin Proteolysis

1997 • 479 citations

Cut2 proteolysis required for sister-chromatid separation in fission yeast

1996 • 451 citations

Drosophila fizzy-related Down-Regulates Mitotic Cyclins and Is Required for Cell Proliferation Arrest and Entry into Endocycles

1997 • 421 citations

ALTERED FIDELITY OF MITOTIC CHROMOSOME TRANSMISSION IN CELL CYCLE MUTANTS OF S. CEREVISIAE

1985 • 390 citations

Fission Yeast Slp1: An Effector of the Mad2-Dependent Spindle Checkpoint

1998 • 381 citations

CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition

1995 • 369 citations

The spindle assembly checkpoint

1996 • 364 citations

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).

1996 • 357 citations

Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint.

1995 • 344 citations

Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3.

1995 • 286 citations

APC-Mediated Proteolysis of Ase1 and the Morphogenesis of the Mitotic Spindle

1997 • 243 citations

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

1997 • 236 citations

Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast.

1995 • 235 citations

Differential expression of a phosphoepitope at the kinetochores of moving chromosomes

1993 • 231 citations

Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes.

1996 • 189 citations

The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work.

1996 • 188 citations

The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae.

1995 • 180 citations

Two microtubule-associated proteins required for anaphase spindle movement in Saccharomyces cerevisiae [published erratum appears in J Cell Biol 1995 Oct;131(2):561]

1995 • 171 citations

CDK1 Inactivation Regulates Anaphase Spindle Dynamics and Cytokinesis In Vivo

1997 • 164 citations

Cdc20 is essential for the cyclosome-mediated proteolysis of both Pds1 and Clb2 during M phase in budding yeast

1998 • 152 citations

Checkpoint Genes Required To Delay Cell Division in Response to Nocodazole Respond to Impaired Kinetochore Function in the Yeast Saccharomyces cerevisiae

1995 • 137 citations

Microinjection of mitotic cells with the 3F3/2 anti-phosphoepitope antibody delays the onset of anaphase.

1995 • 127 citations

Cell Cycle-regulated Expression, Phosphorylation, and Degradation of p55Cdc

1997 • 125 citations

A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4.

1994 • 120 citations

Centromere DNA mutations induce a mitotic delay in Saccharomyces cerevisiae.

1992 • 113 citations

The spindle checkpoint

1998 • 113 citations

Structural and Mechanical Control of Mitotic Progression

1991 • 110 citations

Cell cycle checkpoints: Arresting progress in mitosis

1997 • 103 citations

A Fission Yeast Homolog of CDC20/p55^CDC/Fizzy Is Required for Recovery from DNA Damage and Genetically Interacts with p34^cdc2

1997 • 84 citations

Monoclonal antibodies specific for thiophosphorylated proteins recognize Xenopus MPF

1988 • 62 citations

Mutations of the fizzy locus cause metaphase arrest in Drosophila melanogaster embryos

1993 • 59 citations

A Novel Mammalian Protein, p55CDC, Present in Dividing Cells Is Associated with Protein Kinase Activity and Has Homology to the Saccharomyces cerevisiae Cell Division Cycle Proteins Cdc20 and Cdc4

1994 • 44 citations

MPM-2 antibody-reactive phosphorylations can be created in detergentextracted cells by kinetochore-bound and soluble kinases

1997 • 35 citations

Kinetochore function: molecular motors, switches and gates

1996 • 24 citations

Regulation of the Direction of Chromosome Movement

1991 • 17 citations