Exit from mitosis inDrosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation

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Cyclin is degraded by the ubiquitin pathway

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The embryonic development of Drosophila melanogaster

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SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box

1996 • 1,386 citations

The Embryonic Development of Drosophila melanogaster

1985 • 1,371 citations

How Proteolysis Drives the Cell Cycle

1996 • 1,277 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

1995 • 964 citations

Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.

1996 • 777 citations

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

1995 • 745 citations

How Cells Get the Right Chromosomes

1997 • 625 citations

Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor

1993 • 569 citations

Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast.

1993 • 483 citations

Yeast Hct1 Is a Regulator of Clb2 Cyclin Proteolysis

1997 • 479 citations

Cut2 proteolysis required for sister-chromatid separation in fission yeast

1996 • 451 citations

The roles of Drosophila cyclins A and B in mitotic control

1990 • 429 citations

Expression and function of Drosophila cyclin a during embryonic cell cycle progression

1989 • 399 citations

CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition

1995 • 369 citations

At the heart of the budding yeast cell cycle

1996 • 367 citations

Reversible histone modification and the chromosome cell cycle

1992 • 357 citations

Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint.

1995 • 344 citations

Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis.

1994 • 301 citations

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells

1992 • 298 citations

Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates.

1996 • 288 citations

Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3.

1995 • 286 citations

Budding Yeast SKP1 Encodes an Evolutionarily Conserved Kinetochore Protein Required for Cell Cycle Progression

1996 • 284 citations

APC-Mediated Proteolysis of Ase1 and the Morphogenesis of the Mitotic Spindle

1997 • 243 citations

Synergistic action of Drosophila cyclins A and B during the G2-M transition.

1993 • 211 citations

Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast

1996 • 185 citations

The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe.

1996 • 162 citations

Alteration of Cell Cycle-dependent Histone Phosphorylations by Okadaic Acid

1996 • 133 citations

S-phase function of Drosophila cyclin A and its downregulation in G1 phase

1997 • 103 citations

Mitotic destruction of the cell cycle regulated NIMA protein kinase of Aspergillus nidulans is required for mitotic exit.

1995 • 100 citations

Inhibition of histone phosphorylation by staurosporine leads to chromosome decondensation

1994 • 89 citations

Delays in anaphase initiation occur in individual nuclei of the syncytial Drosophila embryo.

1993 • 87 citations

The Cell Cycle Program in Germ Cells of theDrosophilaEmbryo

1998 • 78 citations

Mitosis‐specific histone H3 phosphorylation in vitro in nucleosome structures

1990 • 76 citations

Drosophila Wee1 kinase rescues fission yeast from mitotic catastrophe and phosphorylates Drosophila Cdc2 in vitro.

1995 • 72 citations

Cyclins A and B associate with chromatin and the polar regions of spindles, respectively, and do not undergo complete degradation at anaphase in syncytial Drosophila embryos.

1992 • 71 citations

A Subunit of the Anaphase-Promoting Complex Is a Centromere-Associated Protein in Mammalian Cells

1998 • 63 citations

Mitotic arrest caused by the amino terminus of Xenopus cyclin B2.

1993 • 48 citations

Dmcdc2 kinase is required for both meiotic divisions during Drosophila spermatogenesis and is activated by the Twine/cdc25 phosphatase

1995 • 46 citations

Cdks and the Drosophila cell cycle

1997 • 39 citations

Relationship between histone phosphorylation and premature chromosome condensation

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Vanadate Triggers the Transition from Chromosome Condensation to Decondensation in a Mitotic Mutant (tsTM13)

1996 • 32 citations

Cloning of Drosophila MCM homologs and analysis of their requirement during embryogenesis

1997 • 22 citations

Mitotic Arrest Caused by the Amino Terminus of Xenopus Cyclin B2

1993 • 11 citations