The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle.

Antibodies, a laboratory manual

1989 • 12,929 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

A simple method for the preparation of 32P-labelled adenosine triphosphate of high specific activity

1964 • 1,880 citations

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

1983 • 1,506 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

Cyclin synthesis drives the early embryonic cell cycle

1989 • 1,223 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

1987 • 1,020 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

1989 • 920 citations

The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis

1988 • 829 citations

Processing of Adenovirus 2-Induced Proteins

1973 • 762 citations

Dominoes and Clocks: the Union of Two Views of the Cell Cycle

1989 • 750 citations

Cyclin is a component of maturation-promoting factor from Xenopus

1990 • 674 citations

cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF

1989 • 666 citations

Oocyte Maturation

1979 • 662 citations

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma

1990 • 660 citations

MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B.

1989 • 550 citations

Regulation of p34cdc2 protein kinase during mitosis

1989 • 544 citations

The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes

1986 • 534 citations

Reversible tyrosine phosphorylation of cdc2: Dephosphorylation accompanies activation during entry into mitosis

1989 • 453 citations

Translation of cyclin mRNA is necessary for extracts of activated Xenopus eggs to enter mitosis

1989 • 438 citations

Control of Cell Division by Very Lysine Rich Histone (F1) Phosphorylation

1974 • 429 citations

Expression and function of Drosophila cyclin a during embryonic cell cycle progression

1989 • 399 citations

p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase.

1987 • 387 citations

The organization of histones and DNA in chromatin: Evidence for an arginine-rich histone kernel

1976 • 371 citations

Purification of MPF from starfish: Identification as the H1 histone kinase p34cdc2 and a possible mechanism for its periodic activation

1989 • 366 citations

Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase

1990 • 344 citations

Fission yeast p13 blocks mitotic activation and tyrosine dephosphorylation of the Xenopus cdc2 protein kinase

1989 • 327 citations

Purified maturation promoting factor phosphorylates pp60c-src at the sites phosphorylated during fibroblast mitosis

1989 • 319 citations

Cyclin is a component of the sea urchin egg M-phase specific histone H1 kinase.

1989 • 308 citations

Dephosphorylation and activation of Xenopusp34cdc2 protein kinase during the cell cycle

1989 • 300 citations

Two complexes that contain histones are required for nucleosome assembly in vitro: Role of nucleoplasmin and N1 in Xenopus egg extracts

1987 • 271 citations

Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2

1989 • 270 citations

Mammalian growth-associated H1 histone kinase: a homolog of cdc2+/CDC28 protein kinases controlling mitotic entry in yeast and frog cells.

1989 • 265 citations

Partial purification and characterization of the maturation-promoting factor from eggs of Xenopus laevis

1980 • 246 citations

Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid.

1990 • 244 citations

Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication

1989 • 242 citations

The role of cyclin B in meiosis I.

1989 • 241 citations

Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase

1989 • 239 citations

Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules.

1988 • 234 citations

Molecular cloning and characterization of the mRNA for cyclin from sea urchin eggs.

1987 • 220 citations

Activation of multiple protein kinases during the burst in protein phosphorylation that precedes the first meiotic cell division in Xenopus oocytes.

1988 • 174 citations

Cell cycle control genes in fission yeast and mammalian cells

1988 • 168 citations

The role of cyclin synthesis, modification and destruction in the control of cell division

1989 • 154 citations

Involvement of protein phosphatases 1 and 2A in the control of M phase-promoting factor activity in starfish.

1989 • 141 citations

Cyclic activation of histone H1 kinase during sea urchin egg mitotic divisions

1988 • 126 citations

Transcripts of one of two Drosophila cyclin genes become localized in pole cells during embryogenesis

1989 • 120 citations

Phosphorylation changes associated with the early cell cycle in Xenopus eggs

1987 • 118 citations

Characterization of the octamer of histones free in solution

1977 • 109 citations

Protein phosphorylation

1982 • 104 citations

RB and the cell cycle: Entrance or exit?

1989 • 93 citations

FURTHER CHARACTERIZATION OF THE F1-HISTONE PHOSPHOKINASE OF METAPHASE-ARRESTED ANIMAL CELLS

1973 • 90 citations

Mammalian Growth-Associated H1 Histone Kinase: a Homolog of cdc2⁺/CDC28 Protein Kinases Controlling Mitotic Entry in Yeast and Frog Cells

1989 • 70 citations

Core histone‐DNA interactions in sea urchin sperm chromatin

1990 • 68 citations

Phosphorylation at clustered -Ser-Pro-X-Lys/Arg- motifs in sperm-specific histones H1 and H2B.

1990 • 66 citations

Biochemical characterization of the p342 protein kinase component of purified maturation-promoting factor from Xenopus eggs

1989 • 53 citations

DNA replication and cell cycle control in Xenopus egg extracts

1989 • 30 citations

Salt-induced folding of sea urchin sperm chromatin

1986 • 29 citations