Polo-like kinases: positive regulators of cell division from start to finish

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

How Proteolysis Drives the Cell Cycle

1996 • 1,277 citations

Chapter 30 Cell Cycle Extracts

1991 • 953 citations

Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.

1996 • 777 citations

Sequence-Specific and Phosphorylation-Dependent Proline Isomerization: A Potential Mitotic Regulatory Mechanism

1997 • 762 citations

GENETIC CONTROL OF THE CELL DIVISION CYCLE IN YEAST: V. GENETIC ANALYSIS OF cdc MUTANTS

1973 • 728 citations

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.

1996 • 685 citations

Monoclonal antibodies to mitotic cells.

1983 • 609 citations

Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles

1988 • 546 citations

Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts

1996 • 506 citations

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae

1998 • 488 citations

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.

1995 • 471 citations

Cut2 proteolysis required for sister-chromatid separation in fission yeast

1996 • 451 citations

CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint

1997 • 433 citations

Drosophila fizzy-related Down-Regulates Mitotic Cyclins and Is Required for Cell Proliferation Arrest and Entry into Endocycles

1997 • 421 citations

polo encodes a protein kinase homolog required for mitosis in Drosophila.

1991 • 403 citations

A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts

1994 • 402 citations

Establishment of the Mechanism of Cytokinesis in Animal Cells

1986 • 381 citations

The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.

1995 • 376 citations

pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis

1998 • 341 citations

The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins

1998 • 340 citations

Role of Polo Kinase and Mid1p in Determining the Site of Cell Division in Fission Yeast

1998 • 327 citations

Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer

1997 • 320 citations

Isolation and characterization of fission yeast mutants defective in the assembly and placement of the contractile actin ring

1996 • 311 citations

PKA and MPF-Activated Polo-like Kinase Regulate Anaphase-Promoting Complex Activity and Mitosis Progression

1998 • 309 citations

Regulation of p34CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae

1992 • 296 citations

S-phase feedback control in budding yeast independent of tyrosine phosphorylation of P34cdc28

1992 • 290 citations

Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5

1994 • 275 citations

A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5.

1993 • 270 citations

Plk Is an M-Phase-Specific Protein Kinase and Interacts with a Kinesin-Like Protein, CHO1/MKLP-1

1995 • 266 citations

The dmf1/mid1 gene is essential for correct positioning of the division septum in fission yeast.

1996 • 259 citations

What does mos do in oocytes and somatic cells?

1997 • 250 citations

Malignant Transformation of Mammalian Cells Initiated by Constitutive Expression of thePolo-like Kinase1

1997 • 246 citations

The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae

1998 • 244 citations

Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk

1998 • 239 citations

Activated Polo-Like Kinase Plx1 Is Required at Multiple Points during Mitosis in Xenopus laevis

1998 • 233 citations

Systematic identification of mitotic phosphoproteins

1997 • 225 citations

The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts

1998 • 214 citations

Meiotic metaphase arrest in animal oocytes: its mechanisms and biological significance

1996 • 212 citations

Checkpoint Pathways Come of Age

1997 • 204 citations

Drosophila Polo Kinase Is Required for Cytokinesis

1998 • 203 citations

On the Regulation and Function of Human Polo-like Kinase 1 (PLK1): Effects of Overexpression on Cell Cycle Progression

1997 • 199 citations

Identification by Targeted Differential Display of an Immediate Early Gene Encoding a Putative Serine/Threonine Kinase

1995 • 196 citations

The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs

1998 • 190 citations

The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1

1998 • 188 citations

Identification of an Early-Growth-Response Gene Encoding a Novel Putative Protein Kinase

1992 • 187 citations

The control of septum formation in fission yeast

1997 • 179 citations

Plk Is a Functional Homolog of Saccharomyces cerevisiae Cdc5, and Elevated Plk Activity Induces Multiple Septation Structures

1997 • 179 citations

Polo-like Kinase Is a Cell Cycle-regulated Kinase Activated during Mitosis

1995 • 165 citations

prk, a Cytokine-inducible Human Protein Serine/Threonine Kinase Whose Expression Appears to be Down-regulated in Lung Carcinomas

1996 • 148 citations

Fission yeast cut mutations revisited: control of anaphase

1998 • 147 citations

GFP tagging reveals human Polo-like kinase 1 at the kinetochore/centromere region of mitotic chromosomes

1998 • 145 citations

A conserved mitotic kinase active at late anaphase—telophase in syncytial Drosophila embryos

1993 • 128 citations

Polo-like kinase, a novel marker for cellular proliferation.

1997 • 118 citations

Human Prk Is a Conserved Protein Serine/Threonine Kinase Involved in Regulating M Phase Functions

1997 • 112 citations

Identification of an early-growth-response gene encoding a novel putative protein kinase.

1992 • 110 citations

The Drosophila POLO kinase localises to multiple compartments of the mitotic apparatus and is required for the phosphorylation of MPM2 reactive epitopes

1998 • 107 citations

MAP Kinase Is Required for the Spindle Assembly Checkpoint but Is Dispensable for the Normal M Phase Entry and Exit in Xenopus Egg Cell Cycle Extracts

1997 • 102 citations

A Role for Mitogen-activated Protein Kinase in the Spindle Assembly Checkpoint in XTC Cells

1997 • 100 citations

Polo kinase: the choreographer of the mitotic stage?

1996 • 97 citations

A Novel Role for Cdc5p in DNA Replication

1996 • 94 citations

Rappaport rules: Cleavage furrow induction in animal cells

1997 • 85 citations

The conserved mitotic kinase polo is regulated by phosphorylation and has preferred microtubule-associated substrates in Drosophila embryo extracts.

1996 • 84 citations

Cell-cycle control: POLO-like kinases join the outer circle

1997 • 77 citations

Expression and phosphorylation of fibroblast-growth-factor-inducible kinase (Fnk) during cell-cycle progression

1998 • 54 citations

Characterisation of a polo-like protein kinase gene homologue from an evolutionary divergent eukaryote, Trypanosoma brucei

1998 • 27 citations