Cellular interactions in vascular growth and differentiation

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

1989 • 4,988 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA

1963 • 3,559 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

1994 • 2,497 citations

Occludin: a novel integral membrane protein localizing at tight junctions.

1993 • 2,466 citations

Thalidomide is an inhibitor of angiogenesis.

1994 • 2,460 citations

Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor

1998 • 2,440 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

Caveolin, a protein component of caveolae membrane coats

1992 • 2,230 citations

Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF

1999 • 2,176 citations

Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice

1997 • 2,136 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

1998 • 2,005 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro

1974 • 1,838 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

1997 • 1,705 citations

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

1996 • 1,670 citations

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

1994 • 1,661 citations

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

1983 • 1,613 citations

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

1986 • 1,588 citations

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1992 • 1,528 citations

Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.

1993 • 1,391 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1990 • 1,308 citations

Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin

1993 • 1,279 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Cardiac Malformation in Neonatal Mice Lacking Connexin43

1995 • 1,242 citations

Angiostatin induces and sustains dormancy of human primary tumors in mice

1996 • 1,193 citations

Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)

1998 • 1,192 citations

Chemotaxis Under Agarose: A New and Simple Method for Measuring Chemotaxis and Spontaneous Migration of Human Polymorphonuclear Leukocytes and Monocytes

1975 • 1,190 citations

Molecular and biological properties of vascular endothelial growth factor

1999 • 1,174 citations

Neuropilin Is a Semaphorin III Receptor

1997 • 1,166 citations

Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms.

1992 • 1,145 citations

PECAM-1 is required for transendothelial migration of leukocytes.

1993 • 1,134 citations

Neuropilin Is a Receptor for the Axonal Chemorepellent Semaphorin III

1997 • 1,131 citations

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

1994 • 1,123 citations

Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation

1992 • 1,103 citations

THALIDOMIDE AND CONGENITAL ABNORMALITIES

1961 • 1,089 citations

Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice

1998 • 1,077 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor

1995 • 1,026 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1994 • 984 citations

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

1994 • 979 citations

Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors.

1992 • 900 citations

Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing.

1992 • 880 citations

Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3

1998 • 876 citations

PDGF-A Signaling Is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis

1996 • 867 citations

Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin

1986 • 854 citations

Defective Angiogenesis in Mice Lacking Endoglin

1999 • 851 citations

Progressive lineage analysis by cell sorting and culture identifies FLK1+VEcadherin+ cells at a diverging point of endothelial and hemopoietic lineages

1998 • 830 citations

A requirement for neuropilin-1 in embryonic vessel formation

1999 • 830 citations

Increased Vascularization in Mice Overexpressing Angiopoietin-1

1998 • 818 citations

PDGF, TGF-β, and Heterotypic Cell–Cell Interactions Mediate Endothelial Cell–induced Recruitment of 10T1/2 Cells and Their Differentiation to a Smooth Muscle Fate

1998 • 789 citations

Vascular endothelial growth factor B, a novel growth factor for endothelial cells.

1996 • 788 citations

Proteolytic processing regulates receptor specificity and activity of VEGF-C

1997 • 773 citations

Role of transforming growth factor-beta in the development of the mouse embryo.

1987 • 760 citations

Identification of a Natural Soluble Form of the Vascular Endothelial Growth Factor Receptor, FLT-1, and Its Heterodimerization with KDR

1996 • 725 citations

Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets

1997 • 719 citations

Matrix Metalloproteinases Regulate Neovascularization by Acting as Pericellular Fibrinolysins

1998 • 716 citations

The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors

1987 • 710 citations

Inhibition of Angiogenesis by Recombinant Human Platelet Factor-4 and Related Peptides

1990 • 710 citations

The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites

1997 • 706 citations

Vascular endothelial growth factor and its receptors

1996 • 686 citations

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

1999 • 681 citations

Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development

1986 • 653 citations

TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoiesis and Vasculogenesis

1996 • 651 citations

Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II.

1992 • 648 citations

Neuropilin–Semaphorin III/D-Mediated Chemorepulsive Signals Play a Crucial Role in Peripheral Nerve Projection in Mice

1997 • 647 citations

Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.

1986 • 645 citations

Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In Vitro

1998 • 638 citations

Platelets as a source of fibroblast growth-promoting activity

1974 • 625 citations

Growth of microvessels in serum-free matrix culture of rat aorta. A quantitative assay of angiogenesis in vitro.

1990 • 599 citations

Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2

1998 • 593 citations

ZO-3, a Novel Member of the MAGUK Protein Family Found at the Tight Junction, Interacts with ZO-1 and Occludin

1998 • 592 citations

Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity

1993 • 574 citations

The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin).

1995 • 573 citations

Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells.

1989 • 568 citations

Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells

1998 • 551 citations

Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development

1995 • 546 citations

Permeability of muscle capillaries to small heme-peptides. Evidence for the existence of patent transendothelial channels.

1975 • 540 citations

Involvement of endothelial PECAM-1/CD31 in angiogenesis.

1997 • 539 citations

Macrophage-Derived Metalloelastase Is Responsible for the Generation of Angiostatin in Lewis Lung Carcinoma

1997 • 537 citations

Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.

1991 • 520 citations

The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

1995 • 517 citations

A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.

1991 • 516 citations

Spatial and temporal expression pattern of N-cadherin cell adhesion molecules correlated with morphogenetic processes of chicken embryos

1987 • 510 citations

Vascular Endothelial Growth Factor/Vascular Permeability Factor Enhances Vascular Permeability Via Nitric Oxide and Prostacyclin

1998 • 506 citations

A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases

1999 • 501 citations

Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells.

1989 • 497 citations

Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors

1991 • 491 citations

Hypoxia and Vascular Endothelial Growth Factor Selectively Up-regulate Angiopoietin-2 in Bovine Microvascular Endothelial Cells

1999 • 490 citations

Assignment of the Vascular Endothelial Growth Factor Gene to Human Chromosome 6p21.3

1996 • 473 citations

Angiopoietin-1 induces sprouting angiogenesis in vitro

1998 • 467 citations

The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.

1993 • 467 citations

Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans

1999 • 463 citations

Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels.

1993 • 463 citations

Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages.

1995 • 452 citations

Expression of transforming growth factor-beta 1 in specific cells and tissues of adult and neonatal mice.

1989 • 451 citations

Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing.

1987 • 450 citations

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system.

1990 • 449 citations

Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases.

1996 • 443 citations

Transforming growth factor-alpha. A model for membrane-anchored growth factors.

1990 • 430 citations

Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice

1999 • 430 citations

Levels of matrix metalloproteases in bladder cancer correlate with tumor grade and invasion.

1993 • 428 citations

A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos.

1986 • 424 citations

Basic fibroblast growth factor enters the nucleolus and stimulates the transcription of ribosomal genes in ABAE cells undergoing G0----G1 transition.

1987 • 422 citations

Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin

1997 • 416 citations

A Novel Type of Vascular Endothelial Growth Factor, VEGF-E (NZ-7 VEGF), Preferentially Utilizes KDR/Flk-1 Receptor and Carries a Potent Mitotic Activity without Heparin-binding Domain

1998 • 412 citations

Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs

1995 • 412 citations

tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.

1992 • 410 citations

A Vascular Endothelial Growth Factor Antagonist Is Produced by the Human Placenta and Released into the Maternal Circulation1

1998 • 408 citations

Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: a potential role for T cells in angiogenesis.

1995 • 397 citations

Basic Fibroblast Growth Factor Upregulates the Expression of Vascular Endothelial Growth Factor in Vascular Smooth Muscle Cells

1995 • 389 citations

Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia.

1993 • 387 citations

Human skin collagenase: isolation of precursor and active forms from both fibroblast and organ cultures

1977 • 387 citations

The serum concentration of active transforming growth factor-β is severely depressed in advanced atherosclerosis

1995 • 386 citations

Expression of transforming growth factor-beta 1 is increased in human vascular restenosis lesions.

1992 • 383 citations

CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium.

1995 • 367 citations

Kringle Domains of Human Angiostatin

1996 • 366 citations

Presence of a growth-stimulating factor in serum following primary tumor removal in mice.

1989 • 365 citations

Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: dependence on interactions with cell surface heparan sulfate

1993 • 365 citations

Flk-1 expression defines a population of early embryonic hematopoietic precursors

1990 • 363 citations

Induction of vasculogenesis and hematopoiesis in vitro

1992 • 345 citations

Characterization of Novel Vascular Endothelial Growth Factor (VEGF) Receptors on Tumor Cells That Bind VEGF165 via Its Exon 7-encoded Domain

1996 • 345 citations

Neuropilin-1 Is a Placenta Growth Factor-2 Receptor

1998 • 344 citations

Biphasic Effect of Transforming Growth Factor-β1 on in Vitro Angiogenesis

1993 • 338 citations

Cell-cell interactions in early embryogenesis: A molecular approach to the role of calcium

1981 • 338 citations

Endothelial Cells Modulate the Proliferation of Mural Cell Precursors via Platelet-Derived Growth Factor-BB and Heterotypic Cell Contact

1999 • 338 citations

The Mouse Gene for Vascular Endothelial Growth Factor

1996 • 335 citations

Vascular Endothelial Growth Factors VEGF-B and VEGF-C Are Expressed in Human Tumors

1998 • 328 citations

Molecular cloning and expression of murine vascular endothelial- cadherin in early stage development of cardiovascular system

1996 • 325 citations

Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent

1991 • 324 citations

The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis.

1993 • 321 citations

Critical Role of the TIE2 Endothelial Cell Receptor in the Development of Definitive Hematopoiesis

1998 • 314 citations

Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus

1994 • 310 citations

Medicine and the Law

1966 • 308 citations

Decreased angiogenesis and arthritic disease in rabbits treated with an αvβ3 antagonist

1999 • 306 citations

Molecular Cloning of a Novel Vascular Endothelial Growth Factor, VEGF-D

1997 • 305 citations

Transforming growth factor-beta-induced growth inhibition and cellular hypertrophy in cultured vascular smooth muscle cells.

1988 • 305 citations

Differential Binding of Vascular Endothelial Growth Factor B Splice and Proteolytic Isoforms to Neuropilin-1

1999 • 304 citations

Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo.

1994 • 296 citations

Inhibition of Angiogenesis by Thalidomide Requires Metabolic Activation, Which Is Species-dependent

1998 • 293 citations

Embryonic lethal mutation in mouse collagen I gene causes rupture of blood vessels and is associated with erythropoietic and mesenchymal cell death

1984 • 285 citations

Vascular integrin alpha(v)beta3: a new prognostic indicator in breast cancer.

1998 • 281 citations

Functional Properties of Human Vascular Endothelial Cadherin (7B4/Cadherin-5), an Endothelium-Specific Cadherin

1995 • 273 citations

Occludin confers adhesiveness when expressed in fibroblasts

1997 • 272 citations

Expression and distribution of cell adhesion molecule uvomorulin in mouse preimplantation embryos

1987 • 271 citations

A platelet factor stimulating human normal glial cells

1976 • 271 citations

Connexin43 Is Highly Localized to Sites of Disturbed Flow in Rat Aortic Endothelium but Connexin37 and Connexin40 Are More Uniformly Distributed

1998 • 269 citations

Dye Tracers Define Differential Endothelial and Smooth Muscle Coupling Patterns Within the Arteriolar Wall

1995 • 264 citations

Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation.

1990 • 262 citations

Embryonic stem cell-derived cystic embryoid bodies form vascular channels: an in vitro model of blood vessel development

1992 • 239 citations

The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system

1993 • 236 citations

Spatial and temporal regulation of gap junction connexin43 in vascular endothelial cells exposed to controlled disturbed flows in vitro

1999 • 230 citations

Purification of a glycoprotein vascular endothelial cell mitogen from a rat glioma-derived cell line.

1990 • 230 citations

The A5 antigen, a candidate for the neuronal recognition molecule, has homologies to complement components and coagulation factors

1991 • 224 citations

Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF ₁₂₁ and VEGF ₁₆₅ but not VEGF ₁₈₉

1997 • 224 citations

Troponin I is present in human cartilage and inhibits angiogenesis

1999 • 221 citations

Targeted null-mutation in the vascular endothelial–cadherin gene impairs the organization of vascular-like structures in embryoid bodies

1997 • 221 citations

VE-Cadherin Mediates Endothelial Cell Capillary Tube Formation in Fibrin and Collagen Gels1

1998 • 216 citations

Cellular localization of matrix metalloproteinases in the abdominal aortic aneurysm wall

1994 • 214 citations

Expression of the Vascular Endothelial Growth Factor C Receptor VEGFR-3 in Lymphatic Endothelium of the Skin and in Vascular Tumors

1998 • 206 citations

Identification of αvβ3 as a heterotypic ligand for CD31/PECAM-1

1996 • 197 citations

VEGF enhances pulmonary vasculogenesis and disrupts lung morphogenesis in vivo

1998 • 195 citations

Mouse Col18a1 is expressed in a tissue-specific manner as three alternative variants and is localized in basement membrane zones.

1995 • 194 citations

Vascular endothelial growth factor-induced in vitro angiogenesis and plasminogen activator expression are dependent on endogenous basic fibroblast growth factor

1997 • 193 citations

Growth Inhibition of Murine Melanoma and Human Colon Carcinoma by Recombinant Human Platelet Factor 4

1990 • 190 citations

Control of Integrin Expression by Extracellular Matrix

1995 • 190 citations

Platelet Factor 4 Modulates Fibroblast Growth Factor 2 (FGF-2) Activity and Inhibits FGF-2 Dimerization

1998 • 168 citations

Inhibition of angiogenesis and tumor growth by a synthetic laminin peptide, CDPGYIGSR-NH2.

1991 • 157 citations

VEGF-induced permeability increase is mediated by caveolae.

1999 • 154 citations

Human microvascular endothelial cells express receptors for platelet-derived growth factor.

1991 • 154 citations

Rat Brain Capillary Endothelial Cells Express Functional PDGF B-Type Receptors

1989 • 153 citations

Gap junction messenger RNA expression by vascular wall cells.

1990 • 152 citations

Aortic Smooth Muscle Cells Express and Secrete Vascular Endothelial Growth Factor

1991 • 148 citations

A fumagillin derivative angiogenesis inhibitor, AGM-1470, inhibits activation of cyclin-dependent kinases and phosphorylation of retinoblastoma gene product but not protein tyrosyl phosphorylation or protooncogene expression in vascular endothelial cells.

1994 • 143 citations

A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4.

1995 • 143 citations

Regulation of Vascular Connexin43 Gene Expression by Mechanical Loads

1998 • 140 citations

The mouse tie receptor tyrosine kinase gene: expression during embryonic angiogenesis.

1994 • 139 citations

Two independent mechanisms essential for tumor angiogenesis: inhibition of human melanoma xenograft growth by interfering with either the vascular endothelial growth factor receptor pathway or the Tie-2 pathway.

1999 • 139 citations

The inhibition of tumor growth by tumor mass.

1991 • 137 citations

Enhanced expression of the tie receptor tyrosine kinase in endothelial cells during neovascularization

1992 • 132 citations

Rat aortic smooth muscle cells become pericytes during angiogenesis in vitro.

1995 • 130 citations

A role for fibronectin in the migration of avian precardiac cells

1988 • 128 citations

Synergy between an antiangiogenic integrin α_vantagonist and an antibody–cytokine fusion protein eradicates spontaneous tumor metastases

1999 • 128 citations

Differential regulation of connexin43 and connexin37 in endothelial cells by cell density, growth, and TGF-beta1

1997 • 127 citations

Endothelin 1: Mitogenic Activity on Pulmonary Artery Smooth Muscle Cells and Release from Hypoxic Endothelial Cells

1992 • 126 citations

Hypoxia‐induced vascular endothelial growth factor expression in normal rat astrocyte cultures

1995 • 125 citations

The embryoid body as a novel in vitro assay system for antiangiogenic agents.

1998 • 123 citations

AN ANTIPHAGE AGENT ISOLATED FROM ASPERGILLUS SP

1949 • 117 citations

The Treatment of Amebiasis with Fumagillin

1952 • 115 citations

Basic fibroblast growth factor (bFGF) dissociates rapidly from heparan sulfates but slowly from receptors. Implications for mechanisms of bFGF release from pericellular matrix.

1992 • 114 citations

Enhanced expression of the tie receptor tyrosine kinase mesenger RNA in the vascular endothelium of metastatic melanomas.

1994 • 112 citations

Expression of matrix metalloproteinase genes in transformed rat cell lines of high and low metastatic potential.

1992 • 112 citations

Induction and maintenance of increased VEGF protein by chronic motor nerve stimulation in skeletal muscle

1998 • 110 citations

Upregulation of Connexin43 Gap Junctions Between Smooth Muscle Cells After Balloon Catheter Injury in the Rat Carotid Artery

1997 • 108 citations

Endothelial cells exhibiting angiogenesis in vitro proliferate in response to TGF‐β1

1993 • 108 citations

Interaction of serum proteins with lung endothelial glycocalyx: its effect on endothelial permeability

1984 • 105 citations

Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation.

1996 • 103 citations

Basic Fibroblast Growth Factor Is Neither Necessary nor Sufficient for the Development of Retinal Neovascularization

1998 • 103 citations

AGM-1470, a potent angiogenesis inhibitor, prevents the entry of normal but not transformed endothelial cells into the G1 phase of the cell cycle.

1994 • 97 citations

Prothrombin Kringle-2 Domain Has a Growth Inhibitory Activity against Basic Fibroblast Growth Factor-stimulated Capillary Endothelial Cells

1998 • 96 citations

The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis

1993 • 96 citations

A comparative study of the expression patterns for vegf, vegf-b/vrf and vegf-c in the developing and adult mouse

1998 • 93 citations

Intercellular communication between vascular smooth muscle and endothelial cells mediated by heparin‐binding epidermal growth factor‐like growth factor and vascular endothelial growth factor

1998 • 89 citations

Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: single agent and combination chemotherapy studies.

1999 • 88 citations

Assembly of Fibronectin into Extracellular Matrix

1991 • 84 citations

A pilot study of the safety and effects of the matrix metalloproteinase inhibitor marimastat in gastric cancer

1999 • 84 citations

Platelet factor 4 blocks the binding of basic fibroblast growth factor to the receptor and inhibits the spontaneous migration of vascular endothelial cells

1990 • 83 citations

Vascular Permeability Factor (Vascular Endothelial Growth Factor) is Strongly Expressed in the Normal Male Genital Tract and is Present in Substantial Quantities in Semen

1995 • 81 citations

Shear Stress Increases Heparin-Binding Epidermal Growth Factor-like Growth Factor mRNA Levels in Human Vascular Endothelial Cells

1993 • 78 citations

Vascular Endothelial Growth Factor Induces Heparin-binding Epidermal Growth Factor-like Growth Factor in Vascular Endothelial Cells

1998 • 77 citations

Vascular endothelial growth factor.

1997 • 74 citations

TGF‐β3‐Mediated tissue interaction during embryonic heart development

1992 • 74 citations

Vascular Endothelial Cadherin (VE‐Cadherin): Cloning and Role in Endothelial Cell‐Cell Adhesion

1997 • 68 citations

MMP-9 (gelatinase B) mRNA is expressed during mouse neurogenesis and may be associated with vascularization

1995 • 67 citations

Endostatin Binds to Blood Vessels in Situ. Independent of Heparan Sulfate and Does Not Compete for Fibroblast Growth Factor-2 Binding

1999 • 61 citations

Differential expression of platelet-derived growth factor α- and β-receptors on fat-storing cells and endothelial cells of rat liver

1991 • 59 citations

VEGF induces cardiovascular malformation and embryonic lethality.

1997 • 58 citations

TGF-beta: structure, function, and formation.

1993 • 57 citations

Astrocytic contributions to blood-brain barrier (BBB) formation by endothelial cells: A possible use of aortic endothelial cell for In vitro BBB model

1996 • 57 citations

Identification of two further gap-junctional proteins, connexin40 and connexin45, in human myometrial smooth muscle cells at term

1998 • 56 citations

Identification of αvβ3 as a heterotypic ligand for CD31/PECAM-1

1996 • 52 citations

TGF-β: Structure, Function, and Formation

1993 • 50 citations

New anti-angiogenesis agents: review of the clinical experience with carboxyamido-triazole (CAI), thalidomide, TNP-470 and interleukin-12.

1997 • 47 citations

THALIDOMIDE AND CONGENITAL ABNORMALITIES

1963 • 44 citations

Expression and regulation of vascular endothelial growth factor in osteoblasts.

1995 • 42 citations

Expression of collagenase and IL‐1α in developing rat hearts

1992 • 34 citations

Phase I trial of recombinant platelet factor 4 (rPF4) in patients with advanced colorectal carcinoma

1996 • 27 citations

TheIn VivoActivity of Vascular Endothelial Growth Factor Isoforms in the Avian Embryo

1998 • 26 citations

Cell-Matrix Interactions in Gland Development in the Lung

1997 • 20 citations

Expression of Platelet-Derived Growth Factor Ligands and Receptors by Rat Aortic Endothelium in vivo

1995 • 16 citations

Occurrence and distribution of matrix metalloproteinase-2-immunoreactivity in human embryonic tissues.

1995 • 11 citations

Nuclear Changes of Ganglion Cells in Experimental Herpetic Encephalitis.

1927 • 10 citations