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1996 • 6,878 citations

Thalidomide is an inhibitor of angiogenesis.

1994 • 2,460 citations

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1995 • 2,300 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

1995 • 1,863 citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1990 • 1,308 citations

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

1993 • 1,206 citations

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Interferon Alfa-2a Therapy for Life-Threatening Hemangiomas of Infancy

1992 • 1,076 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

Inositol Trisphosphate and Calcium Signaling

1995 • 1,036 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 • 976 citations

γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins

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Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo.

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Molecular insights into cancer invasion: strategies for prevention and intervention.

1995 • 500 citations

Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor).

1991 • 471 citations

Thalidomide for the Treatment of Oral Aphthous Ulcers in Patients with Human Immunodeficiency Virus Infection

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Ionic Channels and Their Regulation by G Protein Subunits

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Thalidomide for the Treatment of Chronic Graft-versus-Host Disease

1992 • 394 citations

Antiangiogenic therapy of transgenic mice impairs de novo tumor growth.

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Thalidomide in the treatment of sixty cases of chronic discoid lupus erythematosus

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Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo.

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Thalidomide neuropathy: a clinical electrophysiological, and histological follow-up study.

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Angiogenesis as a marker of preneoplastic lesions of the human breast

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IL-12 induces T helper 1-directed antitumor response.

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Angiogenesis inhibitor TNP-470 (AGM-1470) potently inhibits the tumor growth of hormone-independent human breast and prostate carcinoma cell lines.

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Thalidomide teratogenesis: evidence for a toxic arene oxide metabolite.

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Structure and function of the endothelial cytoskeleton.

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Treatment of refractory rheumatoid arthritis--the thalidomide experience.

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Plasma pharmacokinetics and urinary excretion of thalidomide after oral dosing in healthy male volunteers.

1989 • 119 citations

AN ANTIPHAGE AGENT ISOLATED FROM ASPERGILLUS SP

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In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium, arachidonate, and inositol phosphates.

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The Treatment of Amebiasis with Fumagillin

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Clinical investigation of a cytostatic calcium influx inhibitor in patients with refractory cancers.

1996 • 110 citations

The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release.

1991 • 100 citations

Calcium-mediated signal transduction: biology, biochemistry, and therapy

1994 • 100 citations

Structure-function analysis of signal and growth inhibition by carboxyamido-triazole, CAI.

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Phase I trial of micronized formulation carboxyamidotriazole in patients with refractory solid tumors: pharmacokinetics, clinical outcome, and comparison of formulations.

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Thalidomide-induced peripheral neuropathy

1986 • 74 citations

Suppression of Cyclin D1 mRNA Expression by the Angiogenesis Inhibitor TNP-470 (AGM-1470) in Vascular Endothelial Cells

1994 • 70 citations

The Pharmacokinetics of TNP‐470, a New Angiogenesis Inhibitor

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Treatment of Moderately Severe Erythema Nodosum Leprosum with Thalidomide - A Double-blind Controlled Trial

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Inhibition of angiogenesis and growth of human non-malignant and malignant meningiomas by TNP-470

1995 • 44 citations

Disposition and metabolism of the angiogenic moderator O-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470) in human hepatocytes and tissue microsomes.

1995 • 39 citations

Anti-proliferative effects of TNP-470 on human malignant gliomain vivo: potent inhibition of tumor angiogenesis

1994 • 39 citations

The anti‐tumor effect of recombinant interferon alpha or gamma is influenced by tumor location

1987 • 36 citations

Thapsigargin-Induced Gene Expression in Nonexcitable Cells Is Dependent on Calcium Influx

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Pharmacokinetics of Recombinant Murine Interferon-γ in Mice

1988 • 32 citations

Pharmacokinetics and metabolism of O -(chloroacetyl-carbamoyl) fumagillol (TNP-470, AGM-1470) in rhesus monkeys

1996 • 28 citations

Calcium and cell cycle progression: possible effects of external perturbations on cell proliferation

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Angiogenesis inhibitor TNP-470 suppresses tumorigenesis in rat urinary bladder.

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Studies on the carcinolytic activity of fumagillin and some of its derivatives.

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The mechanism of the push and pull principle. 8. Endocrine effects of thalidomide and its analogues.

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[Motor-conduction velocity of cubital nerves in patients with leprosy reactions. Summary of a 13-year observation series during thalidomide therapy].

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Interspecies variability of TNP-470 metabolism, using primary monkey, rat, and dog cultured hepatocytes.

1997 • 11 citations

FUMAGILLIN ANALOG (TNP-470) IN THE TREATMENT OF KAPOSI'S SARCOMA

1997 • 10 citations