Human microvascular endothelial cells express receptors for platelet-derived growth factor.

Angiogenic Factors

1987 • 3,702 citations

The biology of platelet-derived growth factor

1986 • 2,036 citations

Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis

1977 • 1,286 citations

Epidermal Growth Factor and a New Derivative

1972 • 1,225 citations

Angiogenesis in vitro

1980 • 1,041 citations

Tumor Angiogenesis

1985 • 1,038 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

Two Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors

1989 • 633 citations

Capillary endothelial cell cultures: phenotypic modulation by matrix components.

1983 • 611 citations

Isolation of a Novel Receptor cDNA Establishes the Existence of Two PDGF Receptor Genes

1989 • 610 citations

Cultured endothelial cells produce a platelet-derived growth factor-like protein

1983 • 507 citations

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase.

1989 • 442 citations

Specific receptors for platelet-derived growth factor on cells derived from connective tissue and glia.

1981 • 427 citations

cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.

1989 • 413 citations

Platelet-derived growth factor. II. Specific binding to cultured cells.

1982 • 366 citations

A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain.

1988 • 317 citations

Platelet-derived growth factor stimulates tyrosine-specific protein kinase activity in Swiss mouse 3T3 cell membranes.

1982 • 293 citations

Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation.

1988 • 288 citations

Characterization of a tyrosine-specific kinase activity in human fibroblast membranes stimulated by platelet-derived growth factor.

1982 • 253 citations

Purification of PDGF-AB and PDGF-BB from human platelet extracts and identification of all three PDGF dimers in human platelets

1990 • 226 citations

Expression of the sis gene by endothelial cells in culture and in vivo.

1984 • 221 citations

Sera and conditioned media contain different isoforms of platelet-derived growth factor (PDGF) which bind to different classes of PDGF receptor

1989 • 216 citations

Evidence for the platelet-derived growth factor-stimulated tyrosine phosphorylation of the platelet-derived growth factor receptor in vivo. Immunopurification using a monoclonal antibody to phosphotyrosine.

1984 • 209 citations

Isolation and culture of microvascular endothelium from human adipose tissue.

1983 • 207 citations

Characterization and use of monoclonal antibodies for isolation of phosphotyrosyl proteins from retrovirus-transformed cells and growth factor-stimulated cells.

1983 • 200 citations

Oncogenes and growth control

1985 • 180 citations

Identification and Structural Analysis of the A Type Receptor for Platelet-derived Growth Factor

1989 • 179 citations

Mediation of pinocytosis in cultured arterial smooth muscle and endothelial cells by platelet-derived growth factor

1978 • 171 citations

Insulin Receptors, Receptor Antibodies, and the Mechanism of Insulin Action

1981 • 170 citations

Protein kinase C mediates platelet-derived growth factor-induced tyrosine phosphorylation of p42.

1988 • 166 citations

A glioma-derived analog to platelet-derived growth factor: demonstration of receptor competing activity and immunological crossreactivity.

1984 • 160 citations

Rat Brain Capillary Endothelial Cells Express Functional PDGF B-Type Receptors

1989 • 153 citations

Characterization of platelet-derived growth factor-stimulated phosphorylation in cell membranes.

1983 • 147 citations

Transcriptional regulation of the A and B chain genes of platelet-derived growth factor in microvascular endothelial cells.

1988 • 138 citations

The Effects of Platelet-Derived Growth Factor in Cultured Microvessel Endothelial Cells*

1989 • 137 citations

Induction of platelet-derived growth factor receptor expression in smooth muscle cells and fibroblasts upon tissue culturing.

1988 • 135 citations

The Endothelial Cells of Large and Small Blood Vessels

1981 • 126 citations

Optimized medium for clonal growth of human microvascular endothelial cells with minimal serum

1987 • 124 citations

Human vascular endothelial cells in culture *1Lack of response to serum growth factors

1976 • 118 citations

Processing of the platelet-derived growth factor receptor. Biosynthetic and degradation studies using anti-receptor antibodies.

1987 • 110 citations

Phorbol esters induce angiogenesis in vitro from large‐vessel endothelial cells

1987 • 109 citations

Protein kinase C activators suppress stimulation of capillary endothelial cell growth by angiogenic endothelial mitogens.

1987 • 97 citations

Phenotypic comparison between mesothelial and microvascular endothelial cell lineages using conventional endothelial cell markers, cytoskeletal protein markers and in vitro assays of angiogenic potential

1989 • 94 citations

A Common PDGF rEceptor Is Activated by Homodimeric A and B Forms of PDGF

1988 • 85 citations

Platelet-derived growth factor receptors expressed by cDNA transfection couple to a diverse group of cellular responses associated with cell proliferation.

1988 • 73 citations

Cell lines and peripheral blood leukocytes derived from individuals with chronic myelogenous leukemia display virtually identical proteins phosphorylated on tyrosine residues.

1987 • 72 citations

Characterization and Use of Monoclonal Antibodies for Isolation of Phosphotyrosyl Proteins from Retrovirus-Transformed Cells and Growth Factor-Stimulated Cells

1983 • 66 citations

Major Substrate for Growth Factor-Activated Protein-Tyrosine Kinases Is a Low-Abundance Protein

1985 • 54 citations

Expression of platelet-derived growth factor (PDGF)-related transcripts and synthesis of biologically active PDGF-like proteins by human malignant epithelial cell lines.

1988 • 52 citations

Cloned endothelial cells from fetal bovine bone.

1989 • 48 citations

Cultured endothelial cells do not respond to a platelet-derived growth-factor-like protein in an autocrine manner

1985 • 42 citations

[8] Generation of monoclonal antibodies against phosphotyrosine and their use for affinity purification of phosphotyrosine-containing proteins

1991 • 37 citations

Platelet-derived Growth Factor Receptor Inducibility Is Acquired Immediately after Translation and Does Not Require Glycosylation

1989 • 29 citations

Stimulation of paracrine and autocrine pathways of cell proliferation by platelet-derived growth factor.

1988 • 11 citations