Prothrombin Kringle-2 Domain Has a Growth Inhibitory Activity against Basic Fibroblast Growth Factor-stimulated Capillary Endothelial Cells

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Angiogenesis.

1992 • 2,581 citations

Clinical Applications of Research on Angiogenesis

1995 • 2,300 citations

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

Plasminogen: Purification from Human Plasma by Affinity Chromatography

1970 • 2,160 citations

cDNA sequence of human apolipoprotein(a) is homologous to plasminogen

1987 • 1,842 citations

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

Blood Vessel Formation: What Is Its Molecular Basis?

1996 • 1,242 citations

Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli

1983 • 1,241 citations

Angiostatin induces and sustains dormancy of human primary tumors in mice

1996 • 1,193 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.

1988 • 892 citations

Long-term culture of capillary endothelial cells.

1979 • 780 citations

Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro

1989 • 746 citations

Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity

1993 • 574 citations

Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells.

1989 • 568 citations

Growth factors in wound healing. Single and synergistic effects on partial thickness porcine skin wounds.

1989 • 539 citations

Macrophage-Derived Metalloelastase Is Responsible for the Generation of Angiostatin in Lewis Lung Carcinoma

1997 • 537 citations

Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor.

1990 • 503 citations

Elevated Levels of an Angiogenic Peptide, Basic Fibroblast Growth Factor, in the Urine of Patients With a Wide Spectrum of Cancers

1994 • 478 citations

Purification and physico-chemical characterization of rabbit tumor necrosis factor.

1980 • 386 citations

Kringle Domains of Human Angiostatin

1996 • 366 citations

Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells

1994 • 315 citations

Heterodimers of Placenta Growth Factor/Vascular Endothelial Growth Factor

1996 • 295 citations

Kringle 5 of Plasminogen is a Novel Inhibitor of Endothelial Cell Growth

1997 • 294 citations

The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin

1997 • 292 citations

Effect of fibroblast growth factor and lipoproteins on the proliferation of endothelial cells derived from bovine adrenal cortex, brain cortex, and corpus luteum capillaries

1986 • 273 citations

Quantitation of Angiogenesis and Antiangiogenesis in the Chick Embryo Chorioallantoic Membrane

1994 • 246 citations

Plasminogen

1992 • 214 citations

SDS—PAGE strongly overestimates the molecular masses of the neurofilament proteins

1984 • 189 citations

Heparin-binding fragments of fibronectin are potent inhibitors of endothelial cell growth.

1985 • 118 citations

Tumor necrosis factor inhibits the proliferation of cultured capillary endothelial cells

1987 • 91 citations

Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin

1993 • 88 citations

Amino acid sequence of human prothrombin fragments 1 and 2.

1977 • 87 citations

Mutational analysis and molecular modeling of the N-terminal kringle-containing domain of hepatocyte growth factor identifies amino acid side chains important for interaction with the c-Metreceptor

1994 • 67 citations

The fibrin-binding site of human plasminogen. Arginines 32 and 34 are essential for fibrin affinity of the kringle 1 domain.

1984 • 67 citations

Prothrombin kringle 1 domain interacts with factor Va during the assembly of prothrombinase complex

1997 • 56 citations

Purification of rabbit tumor necrosis factor

1985 • 50 citations

Human plasminogen. Proton NMR studies on kringle 1.

1982 • 43 citations

Purification and preliminary characterization of rabbit vitamin K-dependent coagulation proteins

1990 • 14 citations

Kringle‐kringle interactions in multimer kringle structures

1994 • 13 citations

Sequence and in vitro translational analysis of a 1629-nucleotide ORF in Autographa californica nuclear polyhedrosis virus strain E2

1992 • 12 citations

Cloning and partial sequence of a cDNA for rabbit prothrombin

1991 • 6 citations

Purification and characterization of lipopolysaccharide induced TNF-like factor from rabbit serum

1998 • 1 citations